Carbamazepin 200mg Danapha treats epilepsy and pain relief (100 tablets)

Dosage form Box of 100 capsules
Specifications Carbamazepine
Ingredient Danapha Pharmaceutical Joint Stock Company

Ingredient

Composition information	Content
Carbamazepine	200mg

Uses

Indications

Carbamaxepin drug indications for treatment in the following cases:

epilepsy:

Local epilepsy with complex symptoms (mental mental seizures and temporal lobe epilepsy). Most.

Other indications:

Preventive prophylaxis - depression (not responding to conventional therapy)

Treatment of alcoholic syndrome. The mechanism of action is still unknown. Anti -convulsions are related to neuron stimulation and sinap blockers, mainly by restricting neurons to maintain consecutive start, at high frequency, active electrical active and by the impact in front of Sin to choose to release neurotransmitters, which reduces the transmission through sinap.

Carbamazepine has the effect of fighting the pain in the patient with the pain of Tam Thoa nerve pain, the person who is quitting alcohol and epilepsy. Carbamazepine increases epilepsy threshold, reducing the risk of spasticity and reducing alcoholic symptoms.

pharmacokinetics

After drinking, carbamazepin is almost completely absorbed. Serum peak concentration is achieved after drinking 4 - 8 hours. With a dose of 500 mg oral at hunger, the serum peak concentration of 7.9+ 1.9 mg/liter after 1.6 + 1.3 hours, or after 3.4 +3.4 hours when there is food in the intestinal tract.

from 75 to 78% of the drug is attached to plasma proteins. DISTRIBUTION (VD): 0.88 + 0.06 liters/kg in adults and 1.2 +0.2 liters/kg in children,

Carbamazepin metabolizes the liver to form the carbamazepin - 10, 11 - Poxid has the same activity as the mother compound and has half a generation from 10 to 20 hours. In adults, Epoxid metabolites are in the blood with a concentration of 10 to 15% of the concentration of the mother compound, and in children, the rate is 20%.

Epoxid can cause neurotoxicity, especially when taking the drug simultaneously with phenytoin or phenobarbital, and the increase in the parent epoxide ratio can explain the neurotoxicity of carbamazepine at serum treatment levels.

Because carbamazepin self -metabolizes itself, the half -life of the drug after 1 single dose (31 to 35 hours) is much longer than the half -life of the drug in a stable state (10 to 20 hours). This induction process takes about 4 weeks. Epoxid converts into an inactive compound and eliminates into the urine. Only 3% carbamazepin excreted unchanged in urine. 15% of the drug found in the form of constant.

Before taking Carbamazepin 200mg Danapha treats epilepsy and pain relief (100 tablets)

How to use

Carbamazepin orally.

Dosage

Cleep treatment dose

Priority should be given to a drug but may also need to be coordinated. Carbamazepine must be started in low doses and when increasing or decreasing the dose must gradually take step by step. When adding carbamazepine to anti -seizure treatment, it is advisable to gradually add carbamazepine while having to maintain or gradually decrease the anticonvulsants, except for phenytoin may have to increase the dose.

When stopping carbamazepine, the dose should be reduced slowly to avoid increasing seizures or continuous epilepsy.

For pregnant women should only use single carbamazepin treatment with the lowest possible dose.

Dose for adults and children over 12 years:

The starting dose: 100 - 200 mg, 1 or 2 times/day and every week increases by 200 mg until the maximum response is achieved.

Dosage for children from 6 to 12 years old:

The starting dose: 200 mg/day is divided into 2-4 times/day and every week increases by 100 mg. Dosage must not exceed 1,000 mg/day.

Dosage treatment for peripheral and central nervous nerves

Should take the drug in low doses and increase gradually. Take 100 mg, twice a day, every 3 days increased every time to a maximum dose of 400 mg, twice a day.

Dosage to treat nerve pain tam thuong

Take 100 mg, twice a day. The dose increases slowly to avoid drowsiness. Can be used 400 mg, twice a day. Once the pain has been relieved for a few weeks, the dose gradually decreased.

For the elderly

Carbamazepine clearance is reduced in some elderly people, so the maintenance dose should be lower.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

The first signs and symptoms appear after 1-3 hours. The most prominent are neuromuscular disorders, lighter cardiovascular disorders, severe heart complications that occur only when the dose is very high (> 60 g).

If accompanied by drinking alcohol or using 3 -round antidepressants, barbiturates or Hytantoin, the signs and symptoms of acute carbamazepin poisoning may worsen or change.

Treatment

The prognosis of severe poisoning depends mainly on quickly eliminating drugs, possibly by causing vomiting, gastric lavage, reducing the absorption of the drug by appropriate measures (drinking 100 g of activated carbon, then drinking 50 g from 4 hours, until recovery).

If the above measures cannot be enforced, they must be transferred immediately to the hospital to ensure living functions for patients. There is no specific antidote. Symptomatic treatment and support.

Need to monitor respiratory functions, heart (Monitor of electrocardiogram), blood pressure, temperature, pupil reflexes, kidney function, bladder in a number of days.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when forgetting 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

ADRs often begin to occur are central neurological symptoms. The most common ADR is often related to the dose. Skin reactions encountered with 4 - 6%.

Common, ADR> 1/100

Body: Dizziness. Blood: leukopenia, thrombocytopenia, eucalyptus eosin. Looking at one into two.

Systemic: headache

Blood: Loss of granulocytes, reducing all blood cells, myeloids, huge red blood anemia, mesh red blood cells. Peripheral neuritis, abnormalities, sterile meningitis. Blood, light -sensitive reaction.

Hepatitis: Hepatitis. Bone: muscle pain, joint pain, increased seizures. Prolonged due to reduction of calcium and 25 - OH - Cholecalciferol in plasma, reactions like luput erythema, fever, swelling of lymph nodes.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Carbamaxepin drug is contraindicated in the following cases:

Acute porphyrin metabolism.

Caution when using

Elderly and people with glaucoma, severe cardiovascular disease, liver or kidney disease.

Avoid simultaneous use with inhibitors (IMAO). At least after 14 days of stopping imao, patients can use carbamazepin.

Be cautious when stopping carbamazepine therapy in epilepsy.

Use drugs for women during pregnancy and lactation

Pregnancy

Carbamazepin is at risk of spina bifida. Fingers, toes, skull -shaped, abnormal heart abnormalities in users of anti -epileptic drugs in the first 3 months of pregnancy. The treatment in combination with other anti -convulsions increases the risk of teratogenicity. However, if the control of epilepsy is not effective, it will also increase the risk for both mother and child. It could be a greater threat than the risk of disability for newborns. This must be considered carefully when treating epilepsy during pregnancy.

Breastfeeding period

Carbamazepin accumulated in breast milk (about 25-60% of plasma carbamazepine concentrations), but the risk of breastfeeding is very low at the usual dosage. Mothers using carbamazepin can breastfeed, as long as the child must be monitored unexpected complications (such as sleeping).

The effect of the drug on driving and operating machinery

No data.

Drug interaction

Primidon, Phenytoin, Ethosuximid, Valproic acid and Clonazepam: Carbamazepin 200 mg increases the metabolism speed of primidon, phenytoin, ethosuximid, valproic acid and clonazepam.

propoxyphen, troleandomycin and valproic acid: have the risk of inhibiting carbamazepine clearance mode and increasing blood carbamazepine levels in a stable state.

Other anti -convulsions such as phenytoin and phenobarbital: There is a risk of reducing carbamazepine levels in a stable state through enzyme induction.

Lithi: Concomitance lithium with carbamazepin may increase the risk of nerve side effects, even if the concentration of both lithium and carbamazepin in the blood is toxic.

Mao inhibitors: simultaneously used with carbamazepine causes high fever, hypertension, severe jerks and death. Must inhibitors must be stopped at least 14 days before starting carbamazepin therapy, or vice versa.

Storage

Leave the medicine in a dry place, avoid light.

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