Cardicor Mekophar 2.5 Treatment of hypertension, angina (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Bisoprolol
Ingredient High blood pressure, angina

Ingredient

Composition information	Content
Bisoprolol	2.5mg

Uses

Indications

Cardicor 2.5 mekophar is indicated in the following cases:

Treatment of hypertension, angina. Beta1 but has no membrane stability and has no effect like intrinsic sympathetic nerve when used within the scope of treatment.

In low doses, Bisoprolol inhibits selectively responding to adrenalin stimulation by competing for the Beta1 - adrenergic receptor blocker of the heart, but has little effect on the beta2 receptor adrenergic of bronchial muscles and vascular walls.

With high doses (for example, 20 mg or more), the selective properties of bisoprolol on the beta1 receptor usually decrease and the drug will compete inhibiting both beta1 and beta2 receptors.

The mechanism of lowering the hypotension of Bisoprolol may include the following factors: Reducing cardiac flow, renal inhibitors releasing renin and reducing the impact of sympathetic nerves from vascular centers in the brain. But the most prominent effect of Bisoprolol is to reduce the heart frequency, both resting and at exertion.

pharmacokinetic

absorption

Bisoprolol is almost completely absorbed through the gastrointestinal tract, food does not affect the absorption of drugs. Oral bioavailability is about 90%. After drinking, the peak concentration in plasma is reached from 2 to 4 hours.

Distribution

About 30% of the drug attaches to plasma proteins.

Metabolism and elimination

Half lifetime elimination in plasma from 10 to 12 hours. Metabolic drugs in the liver and excretion in urine, about 50% in constant form and 50% in the form of metabolites.

Before taking Cardicor Mekophar 2.5 Treatment of hypertension, angina (3 blisters x 10 tablets)

How to use

Cardicor 2.5 oral medicine.

Should be taken in the morning, with or without food, not chewing pills.

Dosage

Dosage must be determined for each patient, adjustment depending on the response of the disease and the tolerance of the patient.

Recommended dose:

Treatment of hypertension, angina:

Adults: The usual starting dose is 2.5 - 5 mg/time/day. The dose can be increased to 20 mg/day. The dose can be increased to 20 mg/day. Digital before treatment with bisoprolol.

Treatment of stable chronic heart failure with bisoprolol must start with a dose adjustment period, the dose is gradually increasing according to the following instructions:

week 1: 1.25 mg/time/day, if the intake is well increased. mg/time/day, if better tolerance increases.

week 12 and then: 10 mg/time/day for maintenance treatment.

Maximum doses of recommendations 10 mg/day/day. go up. If necessary to stop treatment, the dose must be reduced slowly.

In some patients, side effects may appear, if it is necessary to reduce the dose slowly, in case of treatment, the treatment may stop and treat them when appropriate.

During the adjustment of the dose, if the heart failure occurs more severe or intolerant to the drug, the dose of bisoprolol must occur, or consider stopping treatment if needed (severe hypotension, severe heart failure with acute pulmonary edema, heart shock, bradycardia or atrial - ventricular heartbeat).

Special cases:

Patients with chronic heart failure or liver failure: There is no information on pharmacokinetics of bisoprolol. It is necessary to be very careful when determining the dose for these cases.

Elderly: No dose adjustment.

Children: There is no adequate experience in using bisoprolol for children, so it is not recommended to use Mekophar 2.5 cardicor for children. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? Severe cases: delirium, coma, convulsions and respiratory stops. Sound blood failure, bronchospasm and hypoglycemia may occur, especially in people who have diseases in these organs.

When an overdose occurs, bisoprolol must be stopped and supported:

Slow heart rate: Atropine intravenous injection. If the response is incomplete, caution can be used with isoproterenol or another drug that increases the heart rate.

Hypotension: intravenous fluid and use drugs that cause hypertension (isoproterenol or a zerava owner 0 - adrenergic). An intravenous glucagon can be used.

Heart block (degrees two or three): careful monitoring of patients and isoproterenol infusion or pacemaker if appropriate.

Bronchospasm: use bronchodilators such as isoproterenol and/or aminophyline. However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using the 2.5 mekophar cardicor, you may experience unwanted effects (ADR).

Common, ADR> 1/100

diarrhea, vomiting, rhinitis, weakness, fatigue.

Uncommon, 1/1000

joint pain, decreased feeling, difficulty sleeping, slow heartbeat, nausea, shortness of breath, chest pain, peripheral edema.

Notify the doctor with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Cardicor 2.5 mekophar medicine is contraindicated in the following cases:

Hypersensitivity to one of the ingredients of the drug.

Patients with cardiac shock, acute heart failure, untreated heart failure by treating background, heart failure III or IV level, atrial atrial clog with two or three and sinus heart rate (less than 60 beats/minute before treatment), sinus node disease.

Severe asthma, chronic bronchodilatoma.

Severe Raynaud syndrome.

adrenal marrow when not treated.

Precautions when using

Avoid using drugs in cases of uncontrolled hemorrhage heart failure.

The drug can cover the symptoms of hypoglycemia such as rapid vessels and clinical manifestations of thyroid disease.

The ability to drive and operate machinery

Cardicor Mekophar 2.5 has a special hypotension effect in patients with heart failure, so the ability to drive and control machinery can be affected. It should be noted this situation when starting treatment, when there is a change of doses as well as when drinking alcohol.

Pregnancy

Using bisoprolol in the early stage of pregnancy is associated with fetal growth. Therefore, it should only be used for pregnant women when really necessary.

Breastfeeding period

Precautions when using the drug for nursing women.

Drug interaction

No Bisoprolol combination with other beta blockers. When combining bisoprolol with drugs that consume catecholamine such as reserpine or guanothidine can cause excessive decrease in sympathetic activity. In patients treated simultaneously with clonidine, if needed to stop treatment, bisoprolol should be stopped for many days before stopping clonidine.

Be cautious when using bisoprolol simultaneously with myocardial inhibitors or inhibition of pediatric transmission - in fact, like some calcium antagonists, especially in the group phenylalkylamine (verapamil) and benzothiazepine (diltiazem), or anti -arrhyths such as disopyramide.

Simultaneous use of rifampicin increases the clearance of bisoprolol metabolism, resulting in shortening the half -life of bisoprolol excretion. However, usually not the first dose adjustment.

To avoid interactions between drugs, notify the doctor or pharmacist about the drugs being used.

Storage

In a dry place, avoid light, the temperature does not exceed 30 ° C.

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