Cardicor Mekophar 5 treatment for high blood pressure, angina (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Bisoprolol
Ingredient Coronary artery disease, high blood pressure, angina

Ingredient

Composition information	Content
Bisoprolol	5mg

Uses

Indications

Cardicor 2.5 mekophar is indicated in the following cases:

Treatment of hypertension, angina.

Treatment of stable chronic heart failure, from medium to severe, accompanied by reduced left ventricular systolic functions that have been treated with transferred, diuretic inhibitors, and with cardiac glycosides. The intrinsic sympathetic nerve when used within the scope of treatment.

In low doses, Bisoprolol inhibits selectively responding to adrenalin stimulation by competing for the Beta1 - adrenergic receptor blocker of the heart, but has little effect on the beta2 receptor adrenergic of bronchial muscles and vascular walls.

With high doses (for example, 20 mg or more), the selective properties of bisoprolol on the beta1 receptor usually decrease and the drug will compete inhibiting both beta1 and beta2 receptors.

The mechanism of lowering the hypotension of Bisoprolol may include the following factors: Reducing cardiac flow, renal inhibitors releasing renin and reducing the impact of sympathetic nerves from vascular centers in the brain. But the most prominent effect of Bisoprolol is to reduce the heart frequency, both resting and at exertion.

pharmacokinetic

absorption

Bisoprolol is almost completely absorbed through the gastrointestinal tract, food does not affect the absorption of drugs. Oral bioavailability is about 90%. After drinking, the peak concentration in plasma is reached from 2 to 4 hours.

Distribution

About 30% of the drug attaches to plasma proteins.

Metabolism and elimination

Half lifetime elimination in plasma from 10 to 12 hours. Metabolic drugs in the liver and excretion in urine, about 50% in constant form and 50% in the form of metabolites.

Before taking Cardicor Mekophar 5 treatment for high blood pressure, angina (3 blisters x 10 tablets)

How to use

"Cardicor 5" medicine for oral use.

Take it before or during breakfast.

Dosage

Dosage as directed by the doctor.

Dosage: Start 1 tablet/day. The dose can be increased to 4 capsules/day. The dose may be increased to 4 capsules/day. The dose may be increased by 2 tablets/day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? Severe cases: delirium, coma, convulsions and respiratory stops. Sound blood failure, bronchospasm and hypoglycemia may occur, especially in people who have diseases in these organs.

When an overdose occurs, bisoprolol must be stopped and supported:

Slow heart rate: Atropine intravenous injection. If the response is incomplete, caution can be used with isoproterenol or another drug that increases the heart rate.

Hypotension: intravenous fluid and use drugs that cause hypertension (isoproterenol or a zerava owner 0 - adrenergic). An intravenous glucagon can be used.

Heart block (degrees two or three): careful monitoring of patients and isoproterenol infusion or pacemaker if appropriate.

Bronchospasm: use bronchodilators such as isoproterenol and/or aminophyline. However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using the 2.5 mekophar cardicor, you may experience unwanted effects (ADR).

Common, ADR> 1/100

diarrhea, vomiting, rhinitis, weakness, fatigue.

Uncommon, 1/1000

joint pain, decreased feeling, difficulty sleeping, slow heartbeat, nausea, shortness of breath, chest pain, peripheral edema.

Notify the doctor with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Cardicor 5 contraindications in the following cases:

Hypersensitivity to one of the ingredients of the drug.

Patients with cardiac shock, acute heart failure, untreated heart failure by treating background, heart failure III or IV level, atrial atrial clog with two or three and sinus heart rate (less than 60 beats/minute before treatment), sinus node disease.

Severe asthma, chronic bronchodilatoma.

Severe Raynaud syndrome.

adrenal marrow when not treated.

Precautions when using

Avoid using drugs in cases of uncontrolled hemorrhage heart failure. Asthma.

The ability to drive and operate machinery

cardicor 5 has a special hypotension effect in patients with heart failure, so the ability to drive and control machinery may be affected. It should be noted this situation when starting treatment, when there is a change of doses as well as when drinking alcohol.

Pregnancy

Using bisoprolol in the early stage of pregnancy is associated with fetal growth. Therefore, it should only be used for pregnant women when really necessary.

Breastfeeding period

Precautions when using the drug for nursing women.

Drug interaction

No Bisoprolol combination with other beta blockers. When combining bisoprolol with drugs that consume catecholamine such as reserpine or guanothidine can cause excessive decrease in sympathetic activity. In patients treated simultaneously with clonidine, if needed to stop treatment, bisoprolol should be stopped for many days before stopping clonidine. (Diltiazem), or anti -arrhyths such as disopyramide. However, usually not to adjust the first dose.

Storage

In a dry place, avoid light, the temperature does not exceed 30 ° C.

Other drugs

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