Carduran 2mg Pfizer treats hypertension, prostate enlargement (1 blister x 10 tablets)

Use doxazosin for hypertension patients to reduce blood pressure significantly clinically due to reducing body blood vessel resistance. This effect is thought to be due to selective inhibition on the sympathetic Alpha receptor on the wall of the circuit. With a single dose of the day, Doxazosin significantly reduces blood pressure throughout the day and 24 hours after drinking.

Blood pressure decreases slowly and reaches up to 2 to 6 hours of medication. In patients with hypertension, blood pressure during treatment with dexazosin is the same in both lying and standing positions. Unlike other non -selective alpha receptors, greasy drugs are not observed during long -term treatment with Doxazosin. Less see the phenomenon of increasing plasma renin activity and tachycardia on long -term treatment cases.

Doxazosin has a beneficial effect on blood lipids, significantly increasing the high density lipoprotein ratio (Hight - HDL)/total cholesterol, decreased triglycerides and total cholesterol. Therefore, the drug has an advantage over diuretics and receptor blockers of sympathetic beta, drugs that have adverse effects on blood lipid indicators. Based on the relationship that has been established between hypertension and lipid disorders and coronary diseases, this beneficial effect of treatment with doxazosin on both blood pressure and blood lipids will help reduce the risk of developing coronary diseases.

DOXAZOSIN therapy shows reducing left ventricular hypertrophy, inhibiting platelet gathering and enhancing the ability to activate the active substance plasminogen tissue. In addition, doxazosin improves insulin sensitivity in less sensitive patients.

Doxazosin has been shown to have no unwanted effect on metabolism and appropriate when used in diabetics, bronchial asthma, left ventricular failure, gout.

A In vitro study showed that the antioxidant properties of metabolic forms of 6/4 and 7 - hydroxy of doxazosin at 5 micromol concentrations.

In a verified clinical study in hypertension patients, doxazosin treatment has been associated with improving erectile dysfunction. In addition, patients who drink doxazosin have been reported to be less than cases of new erectile dysfunction compared to patients who take other antihypertensive drugs.

Prostate fibroids

The use of doxazosin for patients with prostate enlargement significantly improves urinary tract function and other symptoms. Effects on prostate enlargement are thought to be due to the selective inhibition of the sympathetic alpha receptor on the support tissue and the prostate envelope and the bladder neck.

DOXAZOSIN has been shown to inhibit the division 1A of the sympathetic alpha receptor, which is a group that accounts for more than 70% of the doxazosin in prostate fibroid patients.

Doxazosin has also been shown to be effective and safe for long -term treatment for prostate enlargement (for example, up to 48 months).

Pharmacokinetics

absorption

After taking the treatment dose, Doxazosin is well absorbed, the blood concentration in the blood is achieved after about two hours.

Metabolism/excretion

Divide divided into two stages with a half -life of 22 hours. This is the basis for the only dosage of the day. Doxazosin is metabolized in the body, only less than 5% doxazosin excreted in constant form.

Dynamic studies in patients with renal failure have shown that there is no significant difference in pharmacokinetics of doxazosin in patients with renal impairment and patients with normal renal function.

There are only very few data on the use of doxazosin in patients with liver failure and the effects of drugs that have been known to have the effect on liver metabolism (such as cimetidine). In a clinical study in 12 subjects with average liver failure, the single dose of Doxazosin increased 43% AUC and reduced 40% of the clearance of oral dose. As well as for all liver metabolic drugs, be cautious when using doxazosin in patients with liver function changes.

About 98% doxazosin attached to plasma proteins. Doxazosin is metabolized mainly by the methyl reducing reaction of the methoxy group at the ortho position and the hydroxylation reaction.

doxazosin is metabolized in the liver. In vitro studies show that the main excretion path is through CYP 3A4; However, the transformed paths through CYP 2D6 and CYP 2C9 also participate in the elimination process, but at a lower level.

Prelise Clinical Safety Data

Cancer ability

Use Doxazosin lasting up to 24 months) with a maximum tolerance of 40 mg/kg/day in mice and 120 mg/kg/day in mice showing no evidence of cancer likely. The highest dose is used for rats and mice that are associated with AUC (the method of measuring the system concentration), the corresponding AUC value is 3 and 4 times higher than the AUC of the person at 16 mg/day.

The ability to cause gene mutations

Research on gene mutations shows that there is no effect on the exchange or related to drug use at both chromosomes and under chromosomes.

Perfect fertility

Studies on white mice show that the fertility of the male decreases when treated with Doxazosin at a dose of 20mg/kg/day (does not occur at a dose of 5 mg or 10 mg/kg/day), about 4 times the AUC value achieved in humans at a dose of 12mg/day. This effect is turned upside down for 2 weeks if not taken. There is no report on any effects of doxazosin for male fertility.