Casodex 50mg Astrazeneca medicine for prostate cancer treatment (2 blisters x 14 tablets)

Dosage form Box of 2 blisters x 14 tablets
Specifications Bicalutamide
Ingredient Prostate cancer

Ingredient

Composition information	Content
Bicalutamide	50mg

Uses

Indications

Casodex 50mg used in the treatment of prostate cancer in combination with substances with similar structure LHRH or testicular removal surgery.

Pharmacokic

Casodex is an anti -androgen agent of non -steroid group, without other hormonal activity Casodex associated with androgen receptors without manifestation of gene activation and thus inhibits Androgen irritation.

The regression of tumors in the prostate is due to this inhibition. Clinically, stop taking Casodex drugs can lead to anti -antagonistic cessation syndrome in some patients.

Casodex is a racemic isomer with anti -androgen activity, this activity is almost only available in the isomers (R).

Dynamic pharmacokinetics

CASODEX absorb well after drinking. Food does not affect the bioavailability of the drug.

Copygia (s) is faster than the opposite isomer (R), the isomer (R) has a semi -excreted time in plasma about 1 week.

With daily doses of Casodex, the isomers (R) accumulated in plasma about 10 times due to long half -life.

The concentration of the isomer in the image (R) in plasma in a stable state is about 9 mcg/ml when taking the dose of 50mg of Casodex daily. In a stable state, the squad (R) has the main activity that accounts for 99% of the total isomers in the age of age, kidney failure or mild liver failure or just does not affect the pharmacokinetics of the isomer (R).

In patients with severe liver failure, the squad (R) eliminates the plasma slower.

Casodex strongly cohesive? With protein (96%racemic isomers, R-bicalutamid 99.6%) and are strongly metabolized (through oxidation and glucoronylation): The metabolites are excreted through the kidney
and bile at the same proportion.

In a clinical study, the average concentration of R-bicalutamid in the semen of the patient using Casodex 150 mg is 4.9 mcg/ml.

The amount of bicalutamid transmits to the opposite sex when intercourse is very small, only about 0.3 mcg/kg. This amount is lower than that can cause changes on the female of the experimental animal.

Before taking Casodex 50mg Astrazeneca medicine for prostate cancer treatment (2 blisters x 14 tablets)

How to use

Casodex Film tablets for orally.

Dosage

adults

Male including the elderly: 1 tablet (50 mg) once a day. Should start treatment with Casodex at the same time with a substance with the same structure as LHRH or testicular removal surgery.

Children

Contraindications for children for children.

Other objects

Patients with renal failure: No dose adjustment for patients with renal impairment.

Patients with liver failure: No dose adjustment for patients with mild liver failure. The increase in drug accumulation can occur in medium and severe liver failure patients

What to do when overdose? There is no specific antidote, trial treatment is symptomatic treatment. The fertilizer may not be useful of Casodex strongly connected to protein and not returning in a constant form in the urine. It is necessary to indicate treatment for the whole body, including regular monitoring of survival signs.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose?

Side Effects

generally Casodex is well tolerated, only a few cases of stopping treatment due to adverse event.

Table 1: Frequency of adultery

Frequency

Agency Adultery effects The face

Blood

Reproductive and breast disorders The feeling of tension 1, big breasts in men 1 and Metabolic disorders and
nutrition reduced appetite Systemic disorders and condition at the place of use chest pain Vascular, urticaria Respiratory disorders, chest and medium

interstitial lung disease has reported from the death. There has been a death report

2: Change in the liver is rarely severe and transient, often lost or improved when continuing or stopping treatment.

3: Records from pharmaceutical epidemic research on LHRH and Androgen -resistant agents used in the treatment of prostate cancer. The risk of increasing when using Casodex 50 mg in combination with the LHRH owner but does not increase the risk of using CCASODEX 50mg Unit of prostate cancer treatment.

Cardiovascular effects such as angina, heart failure, conduction disorders include extending the PR and QT interval, arrhythmia and no specific ECG changes rarely recorded.

A few cases may be encountered platelets.

Some of the adhering effects are also common symptoms in elderly patients:

cardiovascular system, heart failure.

digestive system, anorexia, dry mouth, indigestion, constipation, flatulence.
Skin and side parts: Hair loss, rash, sweating, hairs

metabolism and nutrition: diabetes, hyperglycemia, edema, weight gain, weight loss.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

CASODEX 50mg Contraindicated in the following cases:

Contraindicated using Casodex for women and children.

Be cautious when using

Casodex strong metabolism in the liver. Data shows that in patients with severe liver failure, elimination may be slower and this may increase Casodex accumulation. Therefore, Casodex should be used cautiously in medium and severe liver failure patients.

Should regularly check the liver function may have changes in the liver. Most changes occur within the first 6 months of treatment with Casodex.

Rarely seriously changes in the liver and liver failure when treated with Casodex (see the unwanted effect). If happened, Casodex should be stopped.

Casodex inhibits Cytochrom P450 (CYP 3A4), so be careful when used with metabolic drugs mainly equal to CYP 3A4 (see contraindications and drug interactions).

Patients with rare genetic problems in tolerance Galactose, Lapp Lactase deficiency or Glucose-Galactose should not be used CASODEX because each pill contains 61 mg lactose monohydrate.

affects the ability to drive and operate machinery

Casodex does not impair the ability to drive or operate the patient's machine.

However, it should be noted that drowsiness can occur occasionally. Any patient is affected, need to be cautious when taking the drug.

Pregnant and lactating women

CASODEX is contraindicated in women and must not be used for pregnant or lactating women.

Drug interaction

There is no evidence of pharmacological interaction or kinetics between Casodex and substances with similar structure LHRH.

In vitro studies show that R-bicalutamid is a CYP 3A4 inhibitor, with a weaker inhibitor on CYP 2C9, 2C19 and 2D6.

Although clinical studies use antipipin as a substance that marks the activity of Cytochrom P450 (CYP), there is no drug interaction with Casodex, the average level of Midazolam contact (area under AUC curve) increases to 80% after use with Casodex in 28 days.

For drugs with narrow treatment limbs, it is important to pay attention to this increase. Therefore, anti -
indicated using Casodex simultaneously with terfenadin, astemizol, cisaprid and cautious when using Casodex with compounds such as ciclosporin and calcium channel blockers.

Need to reduce the dose of these drugs, especially if the adverse effects increase. For ciclosporin, plasma concentration should be carefully monitored and clinical status after the beginning of treatment or after stopping using Casodex.

Be cautious when prescribing Casodex with drugs that can inhibit oxidation such as cimetidine and ketoconazole. In theory, this simultaneous use can increase plasma concentrations and can increase side effects.

In vitro studies showed Casodex and occupied the reserves of anticoagulants of Coumarin, Warfarin at the right positions with protein. So if you start treatment with Casodex in patients who are using coagulants, prothrombin should be carefully monitored.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

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