Caviar 40 Mediplantex Treatment of gastroesophageal reflux disease, gastric ulcer - duodenum (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Esomeprazol
Ingredient Gastroenteritis, gastroenteritis, gastroesophageal reflux, Zollinger-Elison syndrome

Ingredient

Composition information	Content
Esomeprazol	40mg

Uses

Indications

Caviar 40mg drugs are indicated in the following cases:

Gastroesophageal reflux disease Enzyme H+/K+ - ATPASE. Esomeprazol is the isomorphic S- of omeprazol, when entering the body at the pH

pharmacokinetic

absorption

Esomeprazol quickly absorbed through the gastrointestinal tract, the peak concentration in plasma is achieved after 1-2 hours of taking the drug. Increased bioavailability depends on the dose and repeated use, about 68 - 89% for the dose of 20, 40 mg respectively. Food slows down and reduces the absorption of the drug, although this does not significantly affect the effects of Esomeprazol on gastric acid secretion.

Distribution

Esomeprazol binds 97% to plasma proteins.

Metabolism

Esomeprazol is completely metabolized through the liver thanks to the Cytochrome P450 (CYP) system. Most of the metabolism of Esomeprazol depends on the enzyme CYP2C19, forming the metabolites of hydroxy and desmethyl of Esomeprazol - the substance does not affect the secretion of gastric acid.

The rest of the metabolic process depends on the CYP3A4 enzyme, forming Esomeprazol Sulphone. The process of metabolism through the liver for the first time and the body clearance decreases when the dose is repeated, the cause may be due to the inhibition of CYP2C19.

Elimination

Esomeprazol completely eliminates plasma between doses without accumulation when used during the day. Selling time for plasma is about 1.3 hours. About 80% of Esomeprazol is excreted in urine in the form of metabolites, the rest is eliminated in feces.

Before taking Caviar 40 Mediplantex Treatment of gastroesophageal reflux disease, gastric ulcer - duodenum (3 blisters x 10 tablets)

How to use

Esomeprazol oral at least 1 hour before eating, swallowing whole pills, not chewing or grinding micro -seeds.

Dosage

Adults and 18 -year -old children>

Esophagitis inflammation due to reflux: 40 mg/time/day for 4 weeks. Should treat 4 more weeks for patients with untreated esophagitis or persistent symptoms.

Gastroesophageal reflux (GERD): dose of 20 mg/time/day in patients without esophagitis.

gastric ulcer - duodenum: dose 20 - 40 mg/time/day for 4 - 8 weeks.

Prevention and treatment of gastric ulcer - duodenal ulcer due to Helicobacter pylori infection: Combined with appropriate antibacterial regimen to eradicate Helicobacter pylori (Esomeprazol + amoxicillin + clarithromycin), dose is 20mg osomeprazol/time x 2 times/day for 7 days.

Prevention and treatment of stomach ulcers due to NSAID use: 20 mg/time/day, for 4-8 weeks.

Treatment of Zollinger - Ellison syndrome: Starting 40 mg/time/day, then adjusted to response. Most patients are controlled at 80 - 160 mg/day, the dose> 80mg is divided 2 times/day.

Elderly, kidney failure

No dose adjustment.

Patients with liver failure

Mild to moderate liver failure: No dose adjustment.

Severe liver failure: Maximum dose of 20 mg/day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Overdose

The oral dose of 160 mg/time is still well tolerated. When using a high doses up to 2400mg, the symptoms occur very diverse, including confusion, drowsiness, blurred vision, fast heart, nausea, sweating, redness, headache and dry mouth.

Handling

There is no specific antidote. In case of overdose, symptomatic treatment and use of supportive measures should be used.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Caviar 40mg, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Headache, abdominal pain, diarrhea, nausea, vomiting, constipation.

Uncommon, 1/1000

Insomnia, dizziness, chicken sleep, dizziness, dry mouth, liver enzyme, dermatitis, itching, rash, urticaria.

Rare, ADR

Platelet reduction, leukemia, fever, fever, anaphylaxis, taste disorders, blurred vision, bronchospasm, stomatitis, hepatitis (with or no jaundice), sensitive to light, baldness, muscle pain, joint pain, difficulty in sweat.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Caviar 40mg drug is contraindicated in the following cases:

History of hypersensitivity to Esomeprazol, substances belonging to Benzimidazole or any ingredients of the drug.

Do not coordinate Esomeprazol with Atazanavir.

Children under 18 years old, breastfeeding women.

Be cautious when using

Eliminate malignant diseases before taking Esomeprazol because the drug can cover symptoms and delay in diagnosis.

Be cautious when used for prolonged use because it can cause stomach atrophy.

The ability to drive and operate machinery

Unused because Esomeprazol can cause headaches, dizziness, sleeping chicken.

Pregnancy

should be cautious when prescribing pregnant women.

Breastfeeding period

Do not use esomeprazol while breastfeeding.

Drug interaction

drugs that have absorption depends on the stomach pH

Simultaneous use of Esomeprazol with drugs with a mechanism of absorption dependent stomach acid such as ketoconazole, iTraconazole ... can reduce the absorption of these drugs.

Esomeprazol significantly reduces the concentration and AUC of Atazanavir. Increasing the dose of Atazanavir to 400mg did not compensate for the effects of ecomeprazol. Do not combine two drugs together.

Metabolic drug by enzyme CYP2C19

Simultaneous use of Esomeprazol with metabolic drugs by CYP2C19 such as diazepam, citalopram, imipramine, clomipramine, phenytoin ... making the concentration of these drugs in plasma can increase, need to decrease the dose.

Clinically, when using 40mg of Esomeprazol for patients who have used warfarin shows that blood clotting time is still within the allowed limit. However, some Inr increase cases have been reported when used in combination with warfarin with esomeprazol.

Esomeprazol has been shown to have no clinical effects on pharmacokinetics of amoxicillin or quinidine.

Storage

In a dry place, avoid light, temperature below 30 ° C.

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