Cedetamine khapharco treatment of allergic rhinitis, urticaria (2 blisters x 15 tablets)

pharmacokinetics

betamethasone is easily absorbed through the digestive tract. The drug is also easily absorbed when used on the spot.

betamethasone quickly distributed into all tissues in the body. The drug through the placenta and can be exported to breast milk in small amounts. During the circulation, Betamethasone is widely linked to plasma proteins, mainly with globulin and the albumin is less.

Synthetic corticosteroids include betamethasone, less spacious links with protein than hydrocorticoson. Their selling time is also longer, Betamethasone is a long -lasting glucocorticoid.

Corticosteroids are metabolized mainly in the liver but also in the kidneys and the exit into the urine. The metabolism of synthetic corticosteroids, including betamethasone, slower and their protein bonding is lower, which can be explained stronger than natural corticosteroids.

Dexchlorpheniramine Maleatate absorbs well when taken and appears in plasma within 30-60 minutes. Plasma peak concentration is about 2.5 to 6 hours after drinking.

dexchlorpheniramine maleate rapidly and highly metabolized. The drug is excreted mainly in the urine in the form of constant or metabolic, the excretion depends on the pH and the urine flow, only a small amount is seen in the feces.

The usual time for acute urticaria treatment must not exceed 10 days, when stopping, the dose must be slowly reduced.

There is no special requirement on cedetamine treatment after use.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? Mental disorder, adrenal insufficiency, muscle weakness.

Treatment: Causes vomiting or gastric wash, symptomatic treatment and supportive treatment.

What to do when forgetting 1 dose? However, if the time to relax with the next dose is too short, skip the forgotten dose and continue the calendar of cedetamine. Do not use double dose to compensate for missed dose.

Uncommon: 1/1000

Most of unwanted effects can often be recovered or reduced by reducing the dose; This method is often preferred than stopping the drug.

Used with food that limits indigestion, which must be limited to sodium and potassium supplements during treatment. Because corticosteroids increase protein catabolism, it is necessary to increase the diet of protein during prolonged treatment.

Using calcium and vitamin D can reduce the risk of osteoporosis caused by corticosteroids during prolonged treatment.

People with a history or a risk factor for stomach ulcers must be treated with anti -ulcer drugs. Patients who are using corticosteroids without anemia need to think of the cause may be due to stomach bleeding.

Because the ingredient has dexchlorpheniramine maleaty should be contraindicated

Children under 6 years old

breastfeeding women

Used with anti -arrhythmia because it can cause torsion.

Be cautious when using

cedetamine contains lactose, so patients with rare genetic disorders in galactose tolerance, lactose lapp or glucose-galactose absorption disorders should not use this drug.

Related to betamethasone:

Corticosteroid dose must be used in general and betamethasone in particular as low as possible to control treatment; When reducing the dose, it must be gradually reduced to avoid the risk of acute adrenal failure.

When using the whole body corticosteroids must be very cautious in case of congestion, new muscle infarction, hypertension, diabetes, epilepsy, glaucom, thyroid disobsk, liver failure, osteoporosis, stomach ulcers and duodenum, mental disorders and kidney failure. In children and the elderly, Betamethasone may increase the risk of some unwanted effects, in addition to being slow in children.

Patients with tuberculosis or suspected tuberculosis must not use corticosteroids in general and betamethasone in particular, except for the case of supplementing treatment for anti -tuberculosis drugs. When using long corticosteroid therapy in people with hidden tuberculosis, closely monitoring and tuberculosis prevention medication.

Immune response when using corticosteroids systems should increase the risk of chickenpox and may be infected with severe herpes zoster, so patients must avoid exposure to these diseases. In case the patient does not have immune response but exposed to chicken pox or measles should be passive immunity.

Do not use living vaccines for patients who are using high -dose corticosteroid therapy for at least 3 months later. However, dead or detoxified vaccines can be used, although the response may decrease,

For the eye: using prolonged corticosteroids can cause cataracts (especially in children), glaucom with the ability to damage optic nerves. In the process of prolonged corticosteroid therapy, regularly monitoring and reducing sodium and adding calcium and potassium to the body.

dexchlorpheniramine: should be used carefully

In elderly patients: can cause hypotension, dizziness, drowsiness. Chronic constipation (risk of intestinal paralysis) and risk of prostate hypertrophy.

Patients with impaired liver, kidney function, elderly (over 60 years) should be cautious when used.

The ability to drive and operate machinery

Cedetamine medicine has a sedative effect causing drowsiness, so it cannot be used for drivers and operating machinery.

Pregnancy

Use corticosteroids during pregnancy or people who are likely to be considered between the benefits and risks of the drug on the mother and the coordination or the fetus.

Because the ability to inhibit adrenal shells in newborns because the mother has used corticosteroids for a long time, when prescribing corticosteroids must consider the needs of the mother and the risk of the fetus. The newborn that the mother takes the corticosteroid dose significantly during pregnancy must be carefully monitored about the signs of adrenal function reduction.

Breastfeeding period

Betamethasone Exports into breast milk and can be harmful to children because the drug can inhibit development and cause other unwanted effects, for example, reducing adrenal gland function. Dexchlorpheniramine can be through breast milk, due to sedative properties, so contraindicated for nursing women.

Medicinal interaction

cedetamine drug contains two active ingredients: betamethasone and dexchlorpheniramine maleat.

Related to betamethasone

paracetamol: corticosteroids induce liver enzymes, which can increase to form a metabolic of toxic paracetamol to the liver. Therefore, when corticosteroids are used with high or prolonged paracetamol paracetamol will increase the risk of liver toxicity.

Concentrated with three -round antidepressants can increase mental disorders caused by corticosteroids.

Concentrated with oral diabetes or insulin drugs may increase blood glucose levels, so it is necessary to adjust the dose of one or both drugs when used simultaneously, may also need to adjust the dose of hypoglycemic drugs after stopping glucocorticoid.

glycosid digitalis: simultaneously used with betamethasone may increase the possibility of arrhythmia or toxicity of digitalis and hypotension.

Concentrated with phenobarbital, phenytoin, rifampicine or ephedrine may increase corticosteroid metabolism, and thus reduce treatment effects.

Patients who use both corticosteroids and estrogen must be monitored on the excessive effect of corticosteroids because estrogen may change the metabolism and protein bonding level of glucocorticoid, leading to reduced waste, increasing half -life, increasing treatment and toxicity of glucocorticoid.

Simultaneous use of betamethasone with anticoagulant drugs of Coumarine may increase or decrease the anticoagulant effect, may need to adjust the dose.

The coordination effect of nonsteroidal or alcoholic anti -inflammatory drugs with glucocorticoids can lead to increased occurrence or increased severity of the gastrointestinal ulcer. Corticosteroids may increase the concentration of salicylate in the blood. Must be cautious when used in combination with aspirin in case of reduction of blood prothrombin.

When using betamethasone may increase the concentration or effect of cholinesterase inhibitors, amphotericin b, cyclosporin, strap benefits, natalizumab, thiazide gums.

In contrast, some drugs will also increase the concentration or effect of betamethasone such as: antifungal drugs of Azol derivatives, calcium channel blockers, quinolon antibiotics, macrolid, trastuzumab.

Related to dexchlorpheniramine maleat.

Monoamine oxidase inhibitors (IMAO) prolongs and increases the effects of antihistamine drugs; may cause severe hypotension.

Concentrated use of dexchlorpheniramine maleaty with alcohol, antidepressants tricyclique, barbiturate or central nervous system inhibitors can increase the sedative effects of dexchlorpheniramine.

dexchlorpheniramine maleatine inhibits phenytoin metabolism and can lead to phenytoin poisoning.

Due to the lack of studies on the correlation of the drug, not mixing this drug with other drugs.