CedIPECT Imexpharm medicine for cough, sputum (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Codeine, glyceryl guaiacolate
Ingredient Imexpharm

Ingredient

Composition informationContent
Codeine10mg
Glyceryl Guaiacolate100mg

Uses

Indications

Cedipect drugs are indicated in the following cases: treatment of dry or irritating symptoms and help Long talks in patients over 12 years old.

Pharmacokology

codeine

Has the effect of reducing coughs due to direct effect on the center of cough in the brain.

glyceryl guaiacolate

Has a long -running effect, according to the mechanism of stimulating respiratory discharge, increasing volume and reducing the viscosity of gas and bronchial fluid.

pharmacokinetics

codeine

is absorbed in the intestine. After drinking, the semi -cancellation time is 3-4 hours, the effect of reducing cough appears within 1-2 hours and can last 4-6 hours.

Codeine is metabolized in the liver, excreted mainly through the kidneys and into the urine in the form of an associated with glucuronic acid. Codeine or product metabolism is very small. Codeine passes the placenta and disperses into breast milk. A small amount of blood barrier.

glyceryl guaiacolate

Good absorption through the gastrointestinal tract. The metabolites are no longer active and excreted through the kidneys. The sale time is about 1 hour.

Before taking CedIPECT Imexpharm medicine for cough, sputum (10 blisters x 10 tablets)

How to use

Oral drugs.

Dosage

Adults and children over 12 years old

Take 1 tablet x 1–3 times/day.

Do not use more than 7 days.

Children 12–18 years old

To treat cough symptoms and help Long talks, cedipect is not recommended for children with respiratory function impairment.

Children under 12 years old

Contraindicated cedipect to treat cough symptoms and help long talks.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

codeine

Supplying controlled oxygen and respiratory support. Severe cases, intravenous intravenous.

glyceryl guaiacolate

Gastrointestinal lavage if detected early, symptomatic treatment.

Chronic

Abuse of preparations can cause kidney stones.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using cedipect drugs, you may experience unwanted effects (ADR).

  • Sleep, dizziness, dizziness.
  • Nausea, vomiting, abdominal pain, constipation.
  • rash.

    • Instructions on how to handle ADR

    Unwanted effects are less likely to occur when taking oral doses by oral treatment. If vomiting a lot, abdominal pain should be stopped. Can use laxative or indented when constipated.

    Warnings

    Before using the drug you need to read the instructions carefully and refer to the information below.

    Contraindicated

    Cedipect drugs contraindicated in the following cases:

  • Sensitive to any ingredients of the drug.
    • respiratory failure. liver disease.

    coughing asthma.

  • Not used to reduce cough in pus and bronchial diseases when spot needing.

    • Pregnant and lactating women.

  • Children under 18 years of age has just performed tonsil cutting or V.A scraping procedure.

    • Patients with genetic metabolism through CYP2D6 super fast.

  • Children under 12 years of age to treat coughs due to high risk of serious and life -threatening reactions.

    • Be cautious when using

    use the drug in the lowest dose effectively and in the shortest time.

    Due to the risk of respiratory failure, using only codeine -containing drugs to relieve acute pain at an average level for children over 12 years old when other painkillers such as paracetamol and ibuprofen are ineffective.

    Be cautious when taking children under 12 years of age because the research information about the effects of drugs on this object is limited.

    Do not recommend the use of Codeine for patients with respiratory problems (wheezing, shortness of breath when sleeping, asthma, waste gas ...).

    impaired liver and kidney function. There is a history of drug addiction.

    For patients with diabetes, high blood pressure, cardiovascular disease, adrenal dysfunction or armor, prostate hypertrophy, increased cranial pressure.

    Patients must be fully rehydrated during the use of the drug.

    Be cautious for patients with porphyrin metabolic disorders.

    Metabolic via CYP2D6: Codeine is converted into morphine (active metabolites) via CYP2D6 liver enzyme in the liver. If part or all of this enzyme is deficient, the patient will not achieve appropriate treatment effect. It is estimated that up to 7% of the white population lacks this enzyme. However, if the patient has strong or super fast metabolic genes, the risk of an opioid poisoning is increased even in the commonly used prescription. These patients have the ability to convert codeine into morphine faster, leading to higher serum morphine levels than expected.

    The common symptoms of Opioid poisoning include consciousness, drowsiness, shallow breathing, pupils, nausea, vomiting, constipation and anorexia. In serious cases, symptoms of circulatory and respiratory decline may appear, may be life -threatening and rarely fatal.

    Estimated ratio of people carrying drug metabolism via CYP2D6 super fast in different races summarized in the lower table:

    racial
    percentage % 3,4–6.5% 1.90% Respiratory, upper and lung respiratory infections, multiple trauma or have just undergone major surgery. These factors can worsen the symptoms of Morphine poisoning.

    The ability to drive and operate machinery

    The drug causes drowsiness, vomiting and nausea, so should be especially cautious for patients operating train and machinery.

    Pregnancy

    cedipect is not recommended for pregnant women.

    Breastfeeding period

    cedipect is not recommended for women who are breastfeeding.

    In the usual dose of treatment, Codeine and active substance can be present in the breast milk very low and does not seem to cause adverse effects on breastfed babies. However, if the patient is a person carrying the metabolic gene through super -fast CYP2D6, morphine (the active metabolite of the codeine) may be found in breast milk with higher concentrations and in very rare cases, which can lead to symptoms of opioid poisoning in newborns, which can cause death.

    Drug interaction

    Do not use alcohol during treatment.

    Be cautious when coordinated with phenothiazine, barbiturate, benzodiazepine, maoi, 3 -round antidepressants, other derivatives of Morphine.

    Codeine reduces cyclosporin metabolism due to Cytochrome P450 inhibitors.

    Storage

    temperature below 30ºC, avoid moisture and light.

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