Cefaclor 250mg Domesco oral powder for infection treatment (10 packs)

Dosage form 10 package box
Specifications Cefaclor
Ingredient Tonsillitis, pharyngitis, otitis media, sinusitis, urinary tract infections, skin infections and soft tissue, acute bronchitis, pneumonia

Ingredient

Composition information	Content
Cefaclor	250mg

Uses

Indications

Cefaclor 250 mg domeso is indicated in the following cases:

Treatment of upper and lower respiratory infections is mild and medium -sized due to sensitive bacteria, especially after using common antibiotics (due to the "recommended national national anti -respiratory infection program) that fails: acute otitis media, acute sinusitis, sore throat, amidanitis recur many times, acute bronchitis with superinfection, pneumonia. For acute pharyngitis due to streptococcus beta blood -soluble group A, the first popular drug is penicillin v to prevent low heart disease.

Treatment of uncomplicated urinary tract infections caused by sensitive bacterial strains (including nephritis - pyelonephritis and cystitis). Do not use for prostatitis because the drug is difficult to penetrate into this organization.

Treatment of skin and soft tissue infections caused by staphylococcus aureus sensitive to methicillin and streptococcus pyogenes sensitive.

Pharmacokology

cefaclor is an oral, semi -synthetic cephalosporin antibiotic, 2nd generation, which kills bacteria that are growing and divided by inhibiting synthesis of bacterial cells.

Cefaclor has the effect of printing vitro for gram-positive bacteria similar to cefalexin, but has a stronger effect on Gram-negative bacteria, especially with Haemophilus Influenzae, Moraxella Catarrhalis, even with H. Influenzae, M. CatVrhalis producing Beta-Lactamase.

On In vitro, Cefaclor works for the majority of the following bacteria: Staphylococus, including the strains producing penicilinase, positive coagulase, negative coagulase, but there is a diagonal manifestation between cefaclor and methicillin; Streptococcus pneumoniae; Streptococcus Pyogenes (Streptococcus Beta Group A); Propionibacterium acnes; Corynebacterium diphtheriae.

Gram -negative aerobic bacteria: Moraxella Catnrhalis; Haemophilus Influenzae (including the birth strain of beta-lactamase, ampicillin resistance); Escherichia coli; Proteus Mirabilis; Klebsiella spp; Citrobacter Diversus; Neisseria gonorrhoeae. Anaerobic bacteria: Bacteroides spp. (except bacteroides fragilis is resistant); peptococcus; peptostreptococcus.

Pharmacokinetics

absorption

Cefaclor is well absorbed after drinking. With a dose of 250 mg and 500 mg, the average peak concentration in plasma is about 7 and 13 mcg/ml, achieved after 30-60 minutes. Food slows down, but the total amount of drugs is absorbed is unchanged, the peak concentration is only 50 - 75% of the peak concentration in patients who are hungry and usually appear later from 45 - 60 minutes.

Distribution

Cefaclor is widely distributed throughout the body, passes through the placenta and excreted in low concentrations. About 25% Cefaclor binds to plasma proteins.

Metabolism and elimination

Cefaclor's waste time in plasma is from 30 to 60 minutes; This time usually lasts a bit longer in people with a reduced renal function. If the kidney function is completely lost, the semi -waste time lasts from 2.3 to 2.8 hours. Cefaclor concentration in serum exceeds the minimum inhibitory concentration, for most sensitive bacteria, at least 4 hours after taking the dose of treatment.

cefaclor quickly excreted through the kidneys; Up to 85% of the doses are eliminated through urine in the form of unchanged within 8 hours, most of them are deducted in the first 2 hours. Cefaclor reached high concentration in urine within 8 hours after drinking, over these 8 hours the peak concentration in the urine reached 600 and 900 mcg/ml after the doses of use, respectively 250 and 500 mg. Probenecid slowed Cefaclor excretion. A little cefaclor is eliminated through blood decomposition.

Before taking Cefaclor 250mg Domesco oral powder for infection treatment (10 packs)

How to use

Take oral, drink at meals or outside meals.

Put the powder in 10 - 15 ml of water (about 2-3 teaspoons) stir and drink immediately.

Dosage

Adults and the elderly

The dose of 250 mg, every 8 hours. Severe cases may increase the dose doubled. Maximum 4 g/day.

Sore throat, bronchitis, tonsillitis, skin and soft tissue infections, uncomplicated urinary tract infections: dose of 250 mg, every 8 hours. In case of more severe infections or less sensitive bacterial bacteria can be used 500 mg, every 8 hours. Treatment period is 10 days.

Cases of recurrent pharyngitis due to streptococcus beta blood -soluble group A, should also be treated for family members carrying asymptomatic pathogens.

Lower respiratory infections: dose 250 mg, every 8 hours. In case of more severe infections (pneumonia) or bacterial strains of isolated bacteria can use 500 mg, every 8 hours. Treatment period is 7 to 10 days.

cefaclor can be used for patients with renal insufficiency. In case of severe renal failure, the dose adjustments for adults are as follows: Creatinine clearance 10 - 50 ml/min, use 50 - 100% common dose. Creatinine clearance

Patients must have regular hemorrhage, so they should start the starting dose of 250 mg - 1 g before hemolysis and maintain treatment dose of 250 - 500 mg every 6 - 8 hours, between separation.

Children

Use 20 mg/kg/24 hours, divided into 3 drinks. May double the doses in severe cases. Maximum dose: 1 g/day. 1 -month -1 -year -old children take 62.5 mg, every 8 hours; Children> 5 years old taking 250 mg, every 8 hours. Safety and efficiency for children under 1 month of age so far has not been determined.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? The severity of epigastric pain and diarrhea related to the dose. If there are other symptoms, may be caused by allergies, or the effect of another poisoning or the current disease of the patient.

When using Cefaclor overdose: No need to wash the stomach, intestines, unless you have taken Cefaclor at a dose of 5 times the normal dose. Protect the respiratory tract for patients, support ventilation and infusion. Reduce the absorption of drugs by giving activated carbon many times. You can wash your stomach and add activated carbon or use activated carbon. The diuretic benefits, the abdominal duct ratio or dialysis have not been determined to be beneficial in the treatment of overdose.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Cefaclor 250 mg Domesco package, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Blood: Eosin hypernagus.

digestive: diarrhea.

Skin: measles skin.

Uncommon, 1/1000

Blood: Test Coombs directly positive, increased lymphocytes, leukopenia, neutropenia.

digestion: Nausea, vomiting. skin: itching, urticaria. Urinary - genital: Itchy genitals, vaginitis, fungal infection candidia .

Rare, 1/10000

Systemic: Anaphylaxis, fever, symptoms like serum (common in children blood: thrombocytopenia, hemolytic anemia.

digestion: fake colitis. liver: increased liver enzymes, hepatitis and jaundice. kidney: interstitial nephritis.

Central nervous system: epilepsy, increased excitement, headache, insomnia, confusion, tone increase, dizziness, hallucinations and chicken sleep. muscle - Bone: joint pain.

Instructions on how to handle ADR

Notify the doctor with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Cefaclor 250 mg Domesco Package in the following cases:

Patients with a history of allergies to cefaclor and cephalosporin group antibiotics.

Be cautious when using

Patients with penicillin allergies because of cross -sensitive.

Cefaclor for a long time can cause fake colitis caused by Clostridium difficile. Caution for patients with a history of gastrointestinal tract, especially colitis. It is necessary to suspect fake colitis when prolonged diarrhea appears, bloody stools in patients are taking or within 2 months after stopping antibiotic therapy.

People with severe impaired renal function because the selling time of cefaclor in patients with anuria is 2.3 - 2.8 hours (compared to 0.6 - 0.9 hours in normal people) so they often do not balance the dose adjustments for average renal impairment patients but must reduce the dose in people with severe renal impairment. Kidney function should be monitored during cefaclor treatment in combination with antibiotics that have the potential toxicity for the kidneys (such as aminoglycosides) or with Furosemid, ethacrynic acid.

The ability to drive and operate machines

drugs do not affect the driver and operate machinery.

Pregnancy

Cephalosporin antibiotics are often considered safe when used for pregnant women. However, because no project has been fully studied in pregnant women, Cefaclor is only designated in pregnant women when really necessary.

The period of breastfeeding

Cefaclor concentration in breast milk is very low. The impact of the drug on breastfeeding is unknown but should be cautious when children have diarrhea, wasting and rash.

Medicine interaction

simultaneously use Cefaclor and Warfarin rarely causing increased prothrombin time, causing clinical bleeding or clinically bleeding. Patients with vitamin K deficiency (diet, malabsorption syndrome) and patients with renal failure are high -risk subjects interactive. For these patients, regular prothrombin should be monitored and dose adjustment if necessary.

Probenecid increases the concentration of cefaclor in serum.

Cefaclor is simultaneously used with aminoglyeoside antibiotics or Furosemid diuretic may increase the toxicity of the kidneys.

Storage

In a dry place, temperatures below 30 ° C, avoid light.

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