Cefaclor 375mg Mebiphar medicine for respiratory infections (1 blister x 10 tablets)

Dosage form Box of 1 blister x 10 tablets
Specifications Cefaclor
Ingredient Tonsillitis, pharyngitis, otitis media, sinusitis, urinary tract infections, skin infections and soft tissue, acute bronchitis, chronic bronchitis

Ingredient

Composition information	Content
Cefaclor	375mg

Uses

indications

Cefaclor Mebiphar 375 mg is indicated in the following cases:

Treatment of respiratory infections caused by sensitive bacteria. Cephalosporin oral, semi -synthetic, 2nd generation, has an antibacterial effect that is developing and dividing by inhibiting synthesis of bacterial cells.

antibacterial spectrum

cefaclor in vitro works for most bacteria strains isolated from patients: Staphylococcus, including strains producing penicilinase, positive coagulase, negative coagulase, but there is diagonal manifestation between cefaclor and methicillin; Streptococcus pneumoniae; Streptococcus Pyogenes (Streptococcus Beta Group A); Moraxella (Branhamella) CatVrhalis; Haemophilus Influenzae (including the strains producing beta-lactamase, ampicillin resistance); Escherichia coli; Proteus Mirabilis; Klebsiella spp; Citrobacter Diversus; Neisseria gonorrhoeae ...

Pharmacokinetics

absorption

The drug is well absorbed after drinking. Take the dose of 250 mg and 500 mg at hunger, the average peak concentration in the blood corresponds to about 7 and 13 micrograms/ml, achieved after 30 to 60 minutes. Food slowly absorbed but the total amount of drugs absorbed is constant, the peak concentration now only reaches 50% to 75% compared to the hunger and usually appears from 45 to 60 minutes.

Distribution

Cefaclor is widely distributed throughout the body, can pass through the placenta and excretion in low concentrations. About 25% Cefaclor binds to plasma proteins. Half of Cefaclor in plasma from 30 to 60 minutes.

Elimination

Cefaclor quickly excreted through the kidneys, up to 85% of the doses of use are eliminated through urine in the form of unchanged within 8 hours. Cefaclor reaches high concentration in urine within 8 hours after drinking, the peak concentration is about 600 and 900 micrograms/ml.

Before taking Cefaclor 375mg Mebiphar medicine for respiratory infections (1 blister x 10 tablets)

How to use

oral medication.

Dosage

This drug is only used by a doctor.

Adults:

Common dose: 1 tablet every 8 hours.

Sore throat, tonsillitis, bronchitis, skin infections and soft tissue, lower urinary tract infections: 1-2 capsules/time, 2 times a day; or 1 tablet/time, 3 times a day.

For severe infections: 2 tablets/time, 3 times a day.

Statistics limit dose: 4 g/day.

Patients with renal failure: may be used for patients with renal impairment. In case of severe renal failure, the dose adjustments for adults are as follows:

Creatinine clearance 10 - 50 ml/min: use 50% common dose.

Elderly: Dosage like adults.

Children:

Common dose: 20 - 40 mg/kg of weight/day, divided into 2-3 times orally.

Nausea, vomiting, epigastric pain, diarrhea.

Handling

It is necessary to consider the overdose of many drugs, drug interactions and abnormal pharmacokinetics in patients. No need to wash the stomach unless taken by 5 times the dose is normal. Protect the respiratory tract for patients, support ventilation and infusion. Reduce absorption by taking activated carbon many times.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Cefaclor Mebiphar 375 mg, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Blood: Eosin hypernagus.

Digestive: diarrhea.

Skin: measles.

Uncommon, 1/1000

Body: Test Coombs directly positive.

Blood: increased lymphocytes, leukemia, neutropenia.

Digestive: Nausea, vomiting.

Skin: itching, urticaria.

Urinary - genital: Itchy genitals, vaginitis, candidiasis infections.

Rare, ADR

Systemic: Anaphylaxis, fever, symptoms like serum (common in children than adults: diverse rods, inflammation or joint pain, fever or no, may be accompanied by enlarged lymph nodes, proteinuria), Stevens - Johnson syndrome, poisoned epidermal necrosis (Lyell syndrome), Body acne skin rash.

Blood: thrombocytopenia, hemolytic anemia.

digestive: fake colitis.

Liver: Increased liver enzyme, hepatitis, jaundice.

Kidney: interstitial nephritis, slight increase in blood urea or serum creatinine or abnormal urine tests.

Central nervous system: Epilepsy (with high doses and impaired renal function), increased agitation, headache, restlessness, insomnia, confusion, increased tone, dizziness, hallucinations, sleeping chicken.

Other parts: joint pain.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Cefaclor Mebiphar 375 mg contraindicated in the following cases:

Sensitive to any ingredients of the drug.

Do not use drugs for patients with a history of hypersensitivity to antibiotics of cephalosporin.

Be cautious when using

Caution for patients with a history of sensitivity to penicillin due to cross -sensitive.

Long -term use can cause fake colitis, caution with patients with a history of gastrointestinal tract, especially colitis.

Be cautious when taking drugs for people with impaired renal function. Dosage should be reduced in patients with severe renal impairment.

The ability to drive and operate machinery

The drug does not affect the ability to drive and operate machinery.

Pregnancy

is only used when it is really necessary because there is no adequate research in pregnant people.

The period of breastfeeding

The concentration of breast milk is very low. The impact of the drug on breastfeeding is unknown, but should note that when children have diarrhea, wasting and rash.

Medicinal interaction

Simultaneous use of cefaclor with warfarin rarely causes increased prothrombin time, causing bleeding or not clinically bleeding. Should regularly monitor prothrombin and adjust the dose if necessary when taking the drug for these patients.

Probenecid increases the concentration of cefaclor in serum.

Simultaneous use with aminoglycosides or furosemid diuretic that increases the toxicity of the kidneys.

Storage

Store in a dry place, the temperature does not exceed 30 ° C, avoiding light.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.