Cefaclor 500mg Vidipha treats infections (1 blister x 10 tablets)

Dosage form Box of 1 blister x 10 tablets
Specifications Cefaclor
Ingredient Tonsillitis, pharyngitis, otitis media, sinusitis, urinary tract infections, skin and soft tissue, acute bronchitis, chronic bronchitis, pneumonia

Ingredient

Composition information	Content
Cefaclor	500mg

Uses

Indications

Cefaclor Vidipha 500 mg is indicated in the following cases:

Treatment of respiratory infections caused by sensitive bacteria, especially after treatment failure with common antibiotics. Heart. As an antibiotic Cephalosporin oral, semi -synthetic, 2nd generation, has the effect of killing bacteria growing and dividing by inhibiting synthesis of bacterial cells.

Cefaclor has the effect of printing Vitro for gram -positive bacteria similar to cephalothin, but has a stronger effect on Gram -negative bacteria, especially with Haemophilus Influenzae and Moraxella Catarrhalis, even with H. Influenzae and M. CatVrhalis producing Beta - Lactamase.

Staphylococcus, including strains of penicillinase, positive coagulase, negative coagulase, however, there is a diagonal manifestation between cefaclor and methicillin; Streptococcus pneumoniae; Streptococcus Pyogenes (Streptococcus Beta Group A); Moraxella (Branhamella) CatVrhalis; Haemophilus Influenzae (including the strains producing beta - lactamase, ampicillin resistance); Escherichia coli; Proteus Mirabilis; Klebsiella spp; Citrobacter Diversus; Neisseria gonorrhoeae; Propionibacterium acnes and bacteroides spp. (except bacteroides fragilis is resistant); peptococcus; peptostreptococcus.

Cefaclor does not work for Pseudomonas spp. or acinetobacter spp. Faecalis as well as the majority of Entobacter spp., Serratia spp

Pharmacokinetics

absorption

Cefaclor is well absorbed after drinking.

Food slows down, but the total amount of drugs is absorbed is still constant, the peak concentration only reaches 50 - 75% of the peak concentration in patients who are hungry and usually appears later from 45 to 60 minutes. The half -life of Cefaclor in plasma from 30 to 60 minutes; This time usually lasts a little longer in people with a reduced renal function.

If the kidney function is completely lost, half -life lasts from 2.3 to 2.8 hours. Cefaclor concentration in serum exceeds the minimum inhibitory concentration, for most sensitive bacteria, at least 4 hours after taking the dose of treatment.

Distribution

cefaclor is widely distributed throughout the body; Going through the placenta and excreting in breast milk at low concentrations. About 25% Cefaclor binds to plasma proteins.

Elimination

cefaclor quickly excreted through the kidneys; Up to 85% of the dosage is eliminated through urine in the form of unchanged within 8 hours, most of the excretion in the first 2 hours.

Cefaclor reaches high concentrations in urine within 8 hours after drinking. Probenecid slowed Cefaclor excretion. A little cefaclor is excreted through hemorrhage.

Before taking Cefaclor 500mg Vidipha treats infections (1 blister x 10 tablets)

How to use

oral, oral drugs, drinking at hunger.

Dosage

Adults

Sore throat, bronchitis, tonsillitis, skin and soft tissue infections, lower urinary tract infections: drink 500 mg, 2 times a day.

Cases of recurrent pharyngitis due to streptococcus Beta group A, should also be treated for family members carrying asymptomatic pathogens. For acute pharyngitis, penicillin V is the first selected drug.

For more severe infections, dose of 500 mg, 3 times a day. The limit dose is usually prescribed for adults: maximum 4 g/day.

Cefaclor can be used for patients with renal impairment. In case of severe renal failure, the dose adjustments for adults are as follows: If the clearance of creatinine is 10–50 ml/min, use 50% of the common dose; If creatinine clearance is less than 10 ml/min, use 25% common doses.

Patients must have a hemorrhage

When the blood separator, half -life of Cefaclor in serum decreased by 25 - 30%. Therefore, for patients who have to hemorrhage regularly, the starting dose should start from 250 - 1000 mg before hemorrhage and maintain the treatment dose of 500 mg every 6 - 8 hours, during the time between the separation.

Elderly

Dosage like adults.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when using overdose? No need to wash the stomach, intestines, unless you have taken Cefaclor 5 times the normal dose. Protection of respiratory tract for patients, ventilation support and infusion.

Reduce the absorption of drugs by giving activated carbon many times. In many cases, this method is more effective than causing vomiting or gastric lavage.

Can wash your stomach and add activated carbon.

Dowers, abdominal dung or dialysis have not been determined to be beneficial in the treatment of overdose.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Cefaclor Vidipha 500 mg, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Eosin leukemia, diarrhea, measles skin rash.

Uncommon, 1/1000

Test Coombs directly positive.

Increase lymphocytes, leukopenia, neutropenia. digestion: Nausea, vomiting.

Skin and subcutaneous tissue: itching, urticaria.

genital: Itchy genitals, vaginitis, Candida fungus.

Rare, 1/10000

Skin and subcutaneous tissue: Stevens - Johnson syndrome, poisoned epidermal necrosis (Lyell syndrome), Body acne skin rash.

Body: Anaphylaxis, fever.

The serum is more common in children than adults: diverse rash, inflammation or joint pain, fever or no, may be accompanied by large lymph nodes, proteinuria. blood: thrombocytopenia, hemolytic anemia. digestive: fake colitis. liver: Increased liver enzyme, hepatitis and jaundice. kidney: interstitial nephritis, slight increase in blood urea or serum creatinine or abnormal urine tests.

Central nervousness: seizures (with high doses and impaired renal function), increased excitement, headache, restlessness, insomnia, increased tone, dizziness, hallucinations and chicken sleep.

Other parts: joint pain.

Instructions on how to handle ADR

Notify the doctor immediately unwanted effects when taking the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Cefaclor Vidipha 500 mg contraindicated in the following cases:

Hypersensitivity to antibiotics of cephalosporin.

Be cautious when using

Caution when taking drugs for patients with a history of hypersensitivity to cephalosporin, especially with cefaclor, or with penicillin, or with other drugs. Must be cautious with patients allergies to penicillin because of cross -sensitive.

Cefaclor long -term use can cause fake colitis. Precautions for patients with a history of gastrointestinal tract, especially colitis.

Be careful when using Cefaclor for people with severe renal function.

Test Coombs (+) during cefaclor treatment.

Find the urinary glucose with false reducing agents.

The ability to drive and operate machinery

Precautions when taking the drug for the driver and operating machinery because the drug can cause dizziness, hallucinations and drowsiness.

Pregnancy

There is no work that has been fully studied in pregnant women. Therefore, Cefaclor is only indicated in pregnant women when necessary.

The period of breastfeeding

Cefaclor concentration in breast milk is very low. The impact of the drug on breastfeeding is unknown but should pay attention when the child has diarrhea, speech and rash.

Drug interaction

simultaneous use of cefaclor and warfarin rarely increases prothrombin time, causing bleeding or not clinically bleeding. For these patients, prothrombin should be monitored regularly and adjust the dose if necessary.

Probenecid increases the concentration of cefaclor in serum.

Cefaclor is simultaneously used with aminoglycoside antibiotics or Furosemide diuretics that increase the toxicity of the kidneys.

Storage

Store in a dry place, the temperature does not exceed 300C, avoiding light.

Other drugs

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