Cefactum 300mg Vietnamese soil treatment for infection (1 blister x 10 tablets)

Dosage form Box of 1 blister x 10 tablets
Specifications Cefdinir
Ingredient Otitis media, urinary tract infections, skin infections and soft tissue, acute bronchitis, gonorrhea, chronic bronchitis, pneumonia

Ingredient

Composition information	Content
Cefdinir	300mg

Uses

Indications

Cefactum drug indicated to treat mild and medium infections caused by sensitive bacteria in the following cases:

Community pneumonia. 3rd generation.

Cefdinir is highly sustainable by the attack of b-lactamase created by Gram-negative and gram-positive bacteria, but may be decomposed by B-Lactam through plasmid intermediaries. Like other 3rd generation cephalosporins such as (cefpodoxim prixetil, ceftibuten), cefdinir has a wide anti -anti -aerobic bacterium, compared to the first -generation Cephalosporin and 2nd generation but not active on almost all animobacter and pseudomonas aeruginosa.

On Invitro, Cefdinir has a strong activity on Staphyllococci and Streptococci than the 3rd generation cephalosporin or oral routes such as (cefpodoxim proxetil, ceftibuten). However, CEFDinir is not active on Enterrococci (Enterrococci Faecalis) and anti -methicillin streatococci.

Experimental sensitivity on in vitro: Staphylococci strains of penicillinase resistance (staphylococci resistant methicillin) also have the ability to resist CEFDinir.

pharmacokinetic

CEFDINIR pharmacokinetics are studied on adults and children from 6 months to 12 months of age. There is no evidence of gender or race related to pharmacokinetics of the drug. In adults, with renal function impairment shows the dynamics of the drug related to changes in kidney function.

CEFDINIR's

Dynamics is not studied in people with liver failure.

absorption

After taking Cefdinir, the peak plasma concentration is reached 2-4 hours after drinking. The bioavailability of Cefdinir for adults is 120%. When taking Cefdinir, bioavailability is estimated at 21% of the single dose of 300mg and 16% of the dose of 600mg. Estimated absorption of bioavailability is 25% after drinking.

In adults, these people are taken 300mg or 600mg, the peak concentration of plasma reaches about 3 hours equivalent to a dose of 1.6 or 2.87 µg/ml. Research results in adults aged 19 to 91 dose 300mg are indicated that the nail concentration in plasma can be up to 44% and the area under the curve (AUC) is 86% higher.

For patients who are children from 6 months - 12 months of age, receive a single dose of 7mg/kg body weight. After taking Cefdinir, the nail concentration of plasma is achieved after 2.2 hours and the average is 3.86 Ug/ml after 1.8 hours.

During hunger, at high -fat meals, reducing the peak concentration in plasma and the area under the AUC curve of Cefdinir corresponding to 10% - 16%.

There is no evidence of cefdinir accumulated in plasma when using dermatology. For people with normal kidney function, cefdinir 1-2 times/day.

distribution

The average distribution of CEFDinir is about 0.35l/kg for adults and 0.67L/kg for children from 6 months - 12 months. Cefdinir moves into gastric juice, lymph nodes, tissue, bronchial, mucosa with a rate of 15% - 48%.

In adults, when cutting tonsils after taking 300mg or 600mg Cefdinir, the average concentration of the drug is 0.25 or 0.36 µg/g after drinking 4 hours. When sinus sinus surgery, the single -dose sinus sinus is 300mg or 600mg, less than 0.12 or 0.21 µg/g of the corresponding dose. In adults, when undergoing bronchoscopy after 4 hours is 0.78 or 1.14 µg/ml and the average at the epithelium is 0.29 or 0.49 µg/ml.

In patients with acute otitis media due to bacteria when taking single dose 7 or 14mg/kg body weight, the average concentration of the drug after 3 hours is 0.21 or 0.72 µg/ml.

CEFDINIR's maximum average concentration in oral solution after 4-5 hours at a dose of 300mg - 600mg is 0.65 or 1.1 µg/ml.

cefdinir has no evidence of distribution into brain fluids after drinking.

cefdinir does not eliminate breast milk at a dose of 600mg.

Cefdinir has about 60-70% of oral doses associated with plasma proteins in both adults and children, this cohesion does not depend on the concentration of the drug.

Elimination

Cefdinir metabolism is negligible and the drug is excreted through the urinary tract mainly through the kidneys with the sale time of 1.7 - 1.8 hours. Oral distribution is about 300mg to 600mg at about 11.6 or 15.5 ml/min and 18.4 or 11.6% of this dose.

In people with kidney failure, the clearance of Cefdinir decline. In patients with 30-60 ml/minute clearance, the peak concentration in plasma and the semi -discharged time of the drug increases to approximately 3 times. In patients with less than 30ml/minute clearance, the peak concentration in plasma increased by 2 times but the sale time and the area under the AUC curve increased by 5 or 6 times.

Cefdinir is absorbed for 4 hours approximately 60% and the sale time for patients with renal failure from 3.2 to 16 hours.

Before taking Cefactum 300mg Vietnamese soil treatment for infection (1 blister x 10 tablets)

How to use

Oral drugs, dissolve pills with 1 glass of water, or drink whole water with water, not used with meals.

Dosage

Adults and children over 13 years old: Take 300mg 12 hours/time used for 5-10 days or 600mg x 1 time/day for 10 days.

In case of pneumonia or skin infection: use a dose of 300mg x 2 times/day for 10 days.

Patients with renal failure with creatinine 30 ml/minute: use 300mg x 1 time/day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? Symptoms and signs of poisoning when using the overdose of antibiotics β - lactam have been known such as nausea, vomiting, epigastric pain, diarrhea, convulsions. The dialysis is effective in the case of cefdinir poisoning due to overdose, especially in the case of kidney failure.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when forgetting 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

The unwanted effect of cefdinir is similar to other oral cephalosporins. Cefdinir is generally tolerated well. Diarrhea is the most unwanted effect that is reported in adults and adolescents 16% and 8% in children using normal doses. Serious cases patients must stop taking the drug.

Notify the physician the unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Cefactum drugs contraindicated in the following cases:

Not for patients allergic to any ingredients of the drug or allergies to antibiotics of cephalosporin group.

Caution when using

Warning the risk of drug resistance in patients with diarrhea related to Clostridium difficile, patients with renal insufficiency.

Be cautious about using drugs for patients allergies to antibiotics Cephalosporin, penicillin.

may need to reduce the dose for patients with renal failure. Must monitor kidney and blood during treatment, especially when taking the drug for a long time with high doses.

In the drug contains excipients with sodium Lauryl Sulfate: Use carefully with people with sensitive skin because it can cause local reactions such as chit or burning sensation.

Use drugs for women during pregnancy and lactation

Pregnancy

The safety of the drug in pregnant women has not been determined. Therefore, be careful when taking drugs in pregnant women or suspected pregnancy, once the consideration of treatment is higher than the risk may occur.

Breastfeeding period

The drug is not excreted in breast milk at a dose of 600mg. However, be cautious when taking medicine for nursing women.

The effect of the drug on driving and operating machinery

The drug does not affect the ability to drive and operate machinery.

Drug interaction

Probenecid reduces the excretion of cefdinir through the renal tubules, thus increasing the concentration of cefdinir.

Used in combination with acid antibiotics reduces CEFDINIR absorption rate.

During treatment with Cefdinir, if you need to use supplements with iron, you should use CEFDinir before or after using iron supplements for at least 2 hours.

Affects subclinical: The false positive reaction may occur when a ketone test in urine with nitroprussid but does not occur this phenomenon when tested with nitroferriccyanid. Using Cefdinir may cause false positive results when testing in the urine with clinitest, benedict solution or fehling solution. When using cefdinir, glucose should be tested by enzyme reaction (such as clinistix or tes-tape). Cephalosporin antibiotics are known to sometimes cause positive results for direct tests.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

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