Cefalexin 500mg Domesco medicine for infections (10 blisters x 10 tablets)

Cefalexin is sustainable with staphylococcus penicilinase, thus works with both staphylococcus aureus strains of penicillinase resistant penicillin (or ampicillin). Cefalexin has the effect of printing vitro on the following bacteria: Streptococcus beta blood -soluble; Staphylococcus, including coagulase strains (+), coagulase (-) and penicilinase; Streptococcus pneumoniae; Some Escherichia Coli, Proteus Mirabilis, some Klebsiella spp., Branhamella Catnrhalis; Shigella. Haemophilus Influenzae often decreases sensitivity.

cefalexin also works on most E. coli resistant ampicillin.

Most of the Enterococcus strains (Streptococcus Faecalis) and a few strains of staphylococcus resistance Cefalexin. Proteus indol is positive, some Enterobacter spp, Pseudomonas Aeruginosa, Bacteroides spp, also see anti -drugs. When testing in vitro, Staphylococcus shows the cross -resistance between cefalexin and methicillin antibiotics.

pharmacokinetics

cefalexin absorbed completely in the digestive tract and reaches the peak concentration in plasma around 9 and 18 micrograms/ml after an hour with the corresponding oral dose of 250 and 500mg respectively; Double dose reaches double peak concentration. Drinking Cefalexin along with food can slow down the ability to absorb but the total amount of absorption drugs does not change.

There are up to 15% of cefalexin doses associated with plasma proteins. Selling duration of plasma in adults with normal kidney function is 0.5 - 1.2 hours, but in newborns longer (5 hours); and increase when renal function decreases.

cefalexin is widely distributed throughout the body, but the amount in cerebrospinal fluid is negligible. Cefalexin passes the placenta and excreted breast milk with low concentrations. Cefalexin is not metabolized. The distribution of Cefalexin is 18 liters/1.78m2 of body area.

About 80% of the dosage deducting urine in the form of unchanged in the first 6 hours via glomerular filtration and excretion in the renal tubules; With a dose of 500mg cefalexin, the concentration of urine is higher than 1mg/ml.

Probenecid slowed down the excretion of cefalexin in the urine. Cefalexin can be found at a concentration that has a therapeutic effect in bile and some cefalexin can be eliminated by this way.

Cefalexin is eliminated through dialysis and peritoneal dialysis (20% - 50%).

Cefalexin stop. If allergies or hypersensitivity are serious, supportive treatment (guaranteed ventilation and use of epinephrin, oxygen, intravenous steroids). If colitis has a mild mild fake membrane, it usually only needs to stop the drug, medium and severe cases, it is necessary to pay attention to the use of epidemics and electrolytes, protein supplements and antibiotic treatment that treat colitis caused by C. Difficile.

Notify the doctor with unwanted effects when using the drug.

Caution when using

cefalexin is usually well tolerated even in patients with allergies to penicillin, but there are also very few cross -allergens.

Use of long -term cefalexin can cause excessive growth of uncertainty bacteria (e.g. Candida, Enterococcus, Clostridium difficile), in this case, stop the drug.

There has been a notice of fake colitis when using broad -spectrum antibiotics, so it is necessary to pay attention to the diagnosis of this disease in patients with severe diarrhea during or after antibiotics.

Like antibiotics eliminated mainly through the kidneys, when renal failure, the dose of cefalexin must be reduced.

In patients with cefalexin, a fake positive reaction when testing the urinary glucose with the "benedict" solution, the "fehling" solution or the "clinitest", but with enzyme tests, it is not affected.

There is a notice of cefalexin causing positive positive Coombs.

The ability to drive and operate machinery

The drug does not affect driving and operating machinery.

Pregnancy

Experimental research and clinical experience have not shown signs of toxicity for pregnancy and teratogenicity. However, only cefalexin should be used for pregnant people when they need it.

Breastfeeding period

Cefalexin concentration in breast milk is very low. Should consider stopping breastfeeding during the time when the mother uses Cefalexin.

Medicinal interaction

Use high -dose cephalosporin along with other drugs that are also toxic to kidneys such as aminoglycosides or strong diuretic (e.g. Furosemid, ethacrynic and piretanid acid) can adversely affect kidney function. Clinical experience shows no problem with cefalexin at the recommended dose.

cholestyramin attached to cefalexin in the intestine slows down their absorption.

Probenecid increases serum levels and increases the selling time of cefalexin.