Cefbuten 200mg AMVI medicine for infections (1 blister x 10 tablets)

Dosage form Box of 1 blister x 10 tablets
Specifications Ceftibuten
Ingredient Otitis media, sinusitis, urinary tract infections, acute bronchitis, chronic bronchitis, pneumonia

Ingredient

Composition information	Content
Ceftibuten	200mg

Uses

Indications

Cefbuten 200 drugs are indicated in the following cases:

Treatment of medium and mild bacterial infections caused by sensitive bacteria, such as acute attacks in chronic bronchitis, upper jaw sinusitis, acute bronchitis, Haemophilus influenzae, Moraxella Catatrhalis, or Streptococcus pneumoniae. Influenzae, Moraxella Catnrhalis, or Streptococcus Pyogenes. Entobacter, or Staphylococci. CEFTIBUTEN inhibits the synthesis of bacterial cell walls. CEFTIBUTEN is sustainable with beta-lactamase enzymes, so the drug is effective for many resistance strains with penicillin or several other antibiotics belonging to the cephalosporin group.

CEFTIBUTEN is highly sustainable with penicillinase and cephalosporinase through plasmid intermediaries, not durable with some cephalosporinase through intermediaries in bacteria such as Citrobacter, Enterobacter and Bacteroides.

pharmacokinetic

absorption

CEFTIBUTEN is quickly absorbed through the digestive system after oral, oral bioavailability of the drug is about 75 - 90%. Food reduces the speed and level of CEFTIBUTEN's absorption, but this impact mainly affects the bioavailability of CEFTIBUTEN when used in the form of more fluid, less effectively used when used in the form of capsules. After taking the dose of 400 mg/time/day, CEFTIBUTEN is capsule in 7 days, the peak concentration of 17.9 mcg/ml on the 7th day.

Distribution

The distribution volume is about 0.21 l/kg in healthy adults and about 0.5 l/kg in children.

After drinking, Ceftibuten distributed into the fluid in the burning place, pulmonary fluid, nasal secretion, saliva, middle ear secretion, tracheal secretion, tonsils.

About 65% of the drug is associated with plasma proteins.

Selling plasma waste time of an average of 2 - 2.4 hours in healthy adults with normal kidney function and 1.9 - 2.5 hours in children 6 months to 16 years old.

Metabolism

CEFTIBUTEN is present in plasma and urine mainly in the form of cis -cebuten. About 10% of trips change into Trans -ceTibuten. Trans isomers are lower, only about 12% compared to CIS isomers. Selling plasma waste time is longer in patients with renal failure.

Elimination

mainly excreted through urine. After taking the dose of 400 mg (studying in a healthy man), about 57-70% of the dosage excreted through urine in the form of unchanged and about 7-20% is excreted in the form of CIS isomers. CEFTIBUTEN passes through the hemolysis membrane.

Before taking Cefbuten 200mg AMVI medicine for infections (1 blister x 10 tablets)

How to use

cefbuten 200 orally, according to the doctor's prescription.

Dosage

Adults and children greater than 12 years old or over 45 kg:

Common dose used 400 mg 1 time/day, used for 10 days.

Children 6 months to 12 years old or under 45 kg:

Common dose used 9 mg/kg x 1 time/day, used for 10 days. The maximum dose of 400 mg/day. Should drink the form of mixed powder to facilitate the division of the dose.

Patients with renal failure:

Creatinine clearance 50 ml/min, or more, can use the usual dosage of ceftibuten.

Creatinine clearance 30 - 49 ml/min, take a dose of 4.5 mg/kg or 200 mg daily.

Creatinine clearance 5 - 29 ml/min, dose 2.25 mg/kg or 100 mg daily.

Because ceftibuten can be passed through a hemolysis membrane, for patients who are hemolysis 2 or 3 times/week, the dose of 400 mg/day can be used at the end of each appraisal.

Patients with liver failure:

Unpretessed dosage.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when using overdose? There is no specific detoxification. The effectiveness of removing the body has not been determined by peritoneal fertilizer.

What to do when forgetting a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using CEFTIBUTEN, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Digestive system: diarrhea usually occurs in children under 2 years old (8%).

Uncommon, 1/1000

Digestive: Nausea, vomiting.

Da: Red Red.

Skin: Stevens -Johnson syndrome, diverse erythema, fake colitis, jaundice. (SGPT) and LDH.

Instructions on how to handle ADR

Redda:

The itchy and peeling reaction, can stop itself if the drug is stopped.

Diverse erythema and Stevens-Johnson syndrome:

Symptoms include sudden appearance, damage to both skin and mucous membranes. This reaction is also accompanied by fever, discomfort and sore throat related to the mucosa (Stevens - Johnson syndrome).

Treatment: Stop using drugs, treatment of glucocorticoid and adrenalin and if needed to curb tissue destruction, use other immunosuppressive drugs.

Palmic colitis caused by clostridium difficile:

If suspected or identified fake colitis due to Clostridium variety must be stopped using ceftibuten. A few mild cases can go away on its own. Handling moderate to severe cases by rehydration, electrolytes and proteins, using antibiotics against Clostridium difficile (such as McTronidazol and oral vancomycin) and surgical evaluation when clinical indications.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

CEFTIBUTEN drug is contraindicated in cases where patients have a history of allergies to antibiotics of cephalosporin groups.

Precautions when used

If in the process of using the drug, in patients with sensitive reactions, the drug must be stopped immediately and use appropriate treatments (such as epinephrin, corticosteroids, and maintain ventilation for patients).

Caution to monitor patients using long -term spectrum antibiotics, due to excessive development of non -sensitive strains.

Should reduce the dose in patients with renal failure.

has not determined the safety and effectiveness in children under 6 months of age.

The ability to drive and operate machinery

Not applicable.

Pregnancy

only used when necessary.

Breastfeeding period

only used when really necessary.

Medicinal interaction

High doses of aluminum aluminum antacids Hydroxyd/Magnesi Hydroxyd, Ranitidin and single dose of theophylin injection: no significant effects occur.

The effect of the drug is less affected by food, so the CEFTIBUTEN capsule can be used simultaneously with food.

Storage

In a cool dry place, avoid light, temperature below 30 ° C.

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