Cefbuten 400mg AMVI medicine for infections (1 blister x 10 tablets)

Dosage form Box of 1 blister x 10 tablets
Specifications Ceftibuten
Ingredient Otitis media, sinusitis, urinary tract infections, acute bronchitis, chronic bronchitis, pneumonia

Ingredient

Composition information	Content
Ceftibuten	400mg

Uses

Indication

cefbuten 400 is indicated in the following cases:

Treatment of medium and mild infections caused by sensitive bacteria such as respiratory infections, acute attacks in chronic bronchitis, upper jaw sinusitis, acute bronchitis, Haemophilus Influenzae, Moraxella Cataxella or Streptococcus pneumoniae. Haemophilus Influenzae, Moraxella Catnrhalis or Streptococcus pyogenes. Enterobacter or Staphylococci. CEFTIBUTEN inhibits the synthesis of bacterial cell walls. CEFTIBUTEN is sustainable with the enzyme beta - lactamase, so the drug works for many resistance strains with penicillin or several other antibiotics belonging to the cephalosporin group.

CEFTIBUTEN is highly sustainable with penicillinase and cephalosporinase through plasmid intermediaries, not durable with some cephalosporinase through intermediaries in bacteria such as Citrobacter, Enterobacter and Bacteroides.

ceftibuten has a clinical effect on the following bacteria:

Gram -positive bacteria: Streptococcus pyogenes, Streptococcus pneumoniae (except for penicillin resistance lines).

Gram -negative bacteria: Haemophilus influenzae (Beta lactamase positive and negative), Haemophilus para - influenzae (Beta lactamase positive and negative), Moraxella CatVrhalis (Branhamella) (mostly Beta Lactamase positive) Klebsiella SP (including: K. Pneumoniae, K. Oxytoca), Proteus Indol (including P. Vulgaris), other Proteus such as Providencia, P. Mirabilis, Entobacter SP (including E. Cloxa and E. Aerogenes), Salmonella Sp, Shigella Sp.

ceftiuten has the activity against the following bacteria but has not yet been clinically valid:

Gram -positive bacteria: Streptococcus group C and group G.

Gram -negative bacteria: Brucella, Neiserria, Aeromonas Hydrophilia, Yersinia Enterocotilica, Providencia Rettgeri, Providencia Stuartii and Citrobacter, Morganella and Serratia lines are non -murky Cephalosporinase.

cevtibuten is not active on Staphylococcus, Enterococcus, Acinetobacter, Listeria, Flavobacteria and Pseudomonas spp. The drug is less acting on most anaerobic bacteria, including bacteroides.

Pharmacokinetics

absorption

CEFTIBUTEN is quickly absorbed through the digestive system after oral, oral bioavailability of the drug is about 75 - 90%. Food reduces the speed and level of CEFTIBUTEN's absorption, but this impact mainly affects the bioavailability of CEFTIBUTEN when used in the form of more fluid, less effectively used when used in the form of capsules. After taking the dose of 400 mg/time/day, CEFTIBUTEN is capsule in 7 days, the peak concentration of 17.9 mcg/ml on the 7th day.

Distribution

The distribution is about 0.21 l/kg in healthy adults and about 0.5 l/kg in children. After drinking, Ceftibuten distributes into the fluid in the burning place, pulmonary fluid, nasal secretion, saliva, middle ear secretion, tracheal secretion, tonsils. About 65% of drugs are linked to plasma proteins. Selling plasma waste time of an average of 2 - 2.4 hours in healthy adults with normal kidney function and 1.9 - 2.5 hours in children 6 months to 16 years old.

Metabolism

CEFTIBUTEN is present in plasma and urine mainly in the form of CIS - CEFTIBUTEN. About 10% of trips change into trans - ceftibuten. Trans isomers are lower, only about 12% compared to CIS isomers. Selling plasma waste time is longer in patients with renal failure.

Elimination

mainly excreted through urine. After taking the dose of 400 mg (studying in a healthy man), about 57-70% of the dosage excreted through urine in the form of unchanged and about 7-20% is excreted in the form of CIS isomers. CEFTIBUTEN passes through the hemolysis membrane.

Before taking Cefbuten 400mg AMVI medicine for infections (1 blister x 10 tablets)

How to use

cefbuten 400 oral use, according to the doctor's prescription.

Dosage

Adults and children greater than 12 years old or over 45 kg

Common dose of 400 mg x 1 time/day, used for 10 days.

Children 6 months to 12 years old or under 45 kg

Common dose of 9 mg/kg x 1 time/day, for 10 days. The maximum dose of 400 mg/day. Should drink the form of mixed powder to facilitate the division of the dose.

Patients with renal failure

Creatinin clearance 50 ml/min, or more: CEFTIBUTEN's usual dose can be used.

Creatinine clearance 30 - 49 ml/minute: Take a dose of 4.5 mg/kg or 200 mg daily.

Creatinine clearance 5 - 29 ml/minute: dose 2.25 mg/kg or 100 mg daily.

Because Ceftibuten passes through the hemolysis membrane, for patients who are hemolysis 2 or 3 times/week, the dose of 400 mg/day can be used at the end of each fertilizer.

Patients with liver failure

Unrespected dose.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? There is no specific detoxification. The effectiveness of removing the body has not been determined by peritoneal fertilizer.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

Unwanted effects (ADR) when using Cefbuten 400 that you may encounter:

Common, ADR> 1/100

Digestive system: diarrhea usually occurs in children under 2 years old (8%).

Uncommon, 1/1000

Digestive: Nausea, vomiting.

DA: Red Red.

Rare, 1/10000

Skin: Stevens - Johnson syndrome, diverse erythema, jaundice.

digestive: fake colitis. Hematology: Hemorrhage, leukopenia, hemoglobin, leukopenia, Eosin hyperpses, platelets.

Endocrine - Metabolism: Increase AST (SGOT), ALT (SGPT) and LDH.

Instructions on how to handle ADR:

Red rash: Itching and peeling reaction, can stop if the drug is stopped.

Diverse erythematosus and Stevens - Johnson syndrome: Symptoms include: Sudden appearance, damage to both skin and mucosa. This reaction is also accompanied by fever, discomfort and sore throat related to the mucosa (Stevens - Johnson syndrome).

Treatment: Stop using drugs, treatment of glucocorticoid and adrenalin. If you need to control the destruction of tissue, use other immunosuppressive drugs.

Palmic colitis due to Clostridium variety: If suspected or identified fake colitis due to Clostridium variety, must stop using CEFTIBUTEN. A few mild cases can go away on its own. Handling moderate to severe cases by rehydration, electrolytes and proteins, using antibiotics against Clostridium difficile (such as Metronidazol and oral Vancomycin) and surgical evaluation when clinical indications.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

CEFBUTEN 400 drug is contraindicated in the following cases:

Patients with a history of allergies to antibiotics of cephalosporin.

Be cautious when used

Prisable to use in patients allergic to penicillin.

If in the process of using the drug, in patients with sensitive reactions, the drug must be stopped immediately and must use appropriate treatments (such as epinephrin, corticosteroids and maintain ventilation for patients).

Caution to monitor patients using long -term spectrum antibiotics, due to excessive development of non -sensitive strains.

Should reduce the dose in patients with renal failure.

has not determined the safety and effectiveness in children under 6 months of age.

The ability to drive and operate machinery

cefbuten does not affect the ability to drive and operate machinery.

Pregnancy

only used when necessary.

Breastfeeding period

only used when really needed.

Interactive drug

High doses of aluminum antacids Hydroxyd/Magnesi Hydroxyd, Ranitidine and single dose of theophylin intravenous: No significant effect occurs.

The effect of the drug is less affected by food, so the CEFTibuten capsule can be used simultaneously with food.

Storage

In a cool dry place, avoid light, temperatures below 30 ° C.

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