Cefdinir 125 oral powder - MV USP MV Treatment infection (10 packs)

Dosage form 10 package box
Specifications Cefdinir
Ingredient USP

Ingredient

Composition information	Content
Cefdinir	125mg

Uses

indications

CEFDINIR 125-MV drug is indicated in cases of mild to medium infections, caused by sensitive bacteria in the following cases:

The pneumonia has a community with the factors of Haemophilus Influenzae, Moraxella Catnrhalis (including Beta-Lactamase), Streptococcus pneumoniae (penicillin sensitive strain). Moraxella catrhalis (including seminarians beta-lactamase), streptococcus pneumoniae (penicillin sensitive strain).

Acute sinusitis caused by Haemophilus Influenzae, Moraxella Catnrhalis (including Beta-Lactamase) and Streptococcus pneumoniae (penicillin sensitive strain).

Pharyngitis/ tonsillitis caused by streptococcus pyogenes.

Skin infections and skin structure: due to Staphylococcus aureus (including Beta-Lactamase) and Streptococcus Pyogenes.

Acute otitis media caused by Haemophilus Influenzae, Moraxella Catarrhalis (including Beta-Lactamase), Streptococcus pneumoniae. Gram -positive and gram -negative bacteria.

Antibacterial spectrum includes:

Gram -positive bacteria: Staphylococcus aureus, Staphyloccus apidermidis (including the Beta Lactamase but sensitive to methicillin), Streptococcus pneumoniae, Streptococcus pyogenes (sensitive to penicillin).

Gram -negative bacteria: Haemophilus Influenzae, Moraxella Catatrhalis, Escherichia Coli, Kensiella Pneumoniae, Proteus Mirabilis, Neisseria Gonorrhoeea.

Mechanism of action:

cefdinir is an antibiotic of the 3rd generation cephalosporin group.

Cefdinir is a bactericidal by inhibiting the synthesis of bacterial cell wall, so bacteria cannot create cell walls and will be broken under the effect of osmotic pressure.

pharmacokinetics

absorption:

The maximum concentration of cefdinir in plasma appears after 2 to 4 hours after drinking. Cefdinir concentration in plasma increases with dose but increases less at the dose from 300mg (7 mg/kg) to 600mg (14 mg/kg). CEFDINIR's predictions are 21% after taking the dose of 300mg.

Distribution:

The average distribution of CEFDinir in adults is 0.35 l/kg (± 0.29), in children (from 6 months to 12 years old) is 0.67 l/kg (± 0.38). Cefdinir is attached to plasma proteins from 60% to 70% in adults and children; Concentration does not depend on concentration.

Metabolism and elimination:

Cefdinir metabolizes negligible. Cefdinir is excreted mainly through the kidney with an average selling time of 1.7 hours.

In healthy people with normal kidney function, the clearance of the kidney is 2.0 (± 1.0) ml/min/kg and the clearance of the kidney after taking the drug is 11.6 (± 6.0) after taking a dose of 300mg. The rate of recovery drugs in the form of unchanged urine after taking the dose of 300mg is 18.4%.

Cefdinir clearance in patients with renal failure.

Before taking Cefdinir 125 oral powder - MV USP MV Treatment infection (10 packs)

How to use

CEFDINIR 125-MV should take medicine immediately after a meal and at least 2 hours before or after taking antacids or iron-containing preparations.

Dosage

Treatment period from 5 to 10 days depending on the case, can be used once a day or divided 2 times/day.

Adults and children over 13 years old: 300 mg 2 times/day or 600 mg/1 time/day. The total dose is 600 mg for infections.

Children from 6 months to 12 years: 7mg/kg x 2 times/day or 14mg/kg/day.

Adjust the recommended dosage in patients with severe renal failure (CLCR

Adults: 300 mg once a day if ClCr

Children: 7mg/kg (maximum 300 mg) once a day if ClCr

Patients with dialysis for a long time: The initial recommended dose is 300 mg every 48 hours in adults and 7mg/kg (up to 300 mg) every 48 hours in children. Additional dose (300 mg in adults or 7mg/kg in children) at the end of each dialysis period.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? Dialysis can eliminate Cefdinir from the body, especially in the case of kidney function.

What to do when forgetting 1 dose?

Not recorded.

Side Effects

When using CEFDinir 125-MV, you may experience unwanted effects (ADR).

Rarely: diarrhea, nausea, headache, abdominal pain, rash, vaginitis.

Very rare: indigestion, flatulence, vomiting, anorexia, constipation, unusual parts, weakness, dizziness, insomnia, itching, sleeping chicken.

Instructions on how to handle ADR:

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

CEFDINIR 125-MV drug is contraindicated in the following cases:

Contraindicated in patients allergic to antibiotics of cephalosporin or any ingredients of the drug.

Contraindicated in people allergies to penicillin.

Be cautious when using

as well as other broad -spectrum antibiotics, long -term treatment with Cefdinir can cause resistance bacteria. It is necessary to monitor patients closely, if there is a phenomenon of re -infection during treatment, it is necessary to change to other antibiotics appropriately.

Be cautious when used for patients with a history of colitis.

People at risk of allergies and anaphylactic reactions.

The ability to drive and operate machinery

There is no report on the impact of the drug on the ability to drive trains or operate machinery in reference materials.

Pregnancy

There is no specific research on pregnant women, only taking drugs when really necessary.

The period of breastfeeding

There is no specific research in breastfeeding women, only taking the drug when really necessary.

Interactive drug

Medications neutralizing gastric acid containing aluminum or magnesium and iron -containing preparations that reduce Cefdinir absorption. These drugs should be used 2 hours before or 2 hours after taking Cefdinir.

Probenecid: Like other β-lactam antibiotics, simultaneously used with probenecid leads to the inhibition of Cefdinir excretion through the kidney

Storage

Store drugs in a dry place, temperatures below 30 ° C, avoid light.

Other drugs

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