Cefimbrano 100 Vidipha oral powder for infection treatment (10 packs x 2g)

Dosage form 10 package box
Specifications Cefixim
Ingredient Vidipha

Ingredient

Composition information	Content
Cefixim	100mg

Uses

Indications

Cefimbrano 100 drugs are indicated in the following cases:

Inhabited urinary tract infections due to sensitive strains E.coli or Proteus Mirabilis and a few cases due to other Gram -negative bacilli such as Citrobacter spp.

nephritis - pyelonephritis and urinary tract infections have complications caused by sensitive enerobacteriaceae.

otitis media caused by Haemophylus influenzae (including beta - lactamase strains), Moraxella Catatrhalis (including beta - lactamase strains), Streptococcus pyogenes.

Sore throat and tonsils due to streptococcus pyogenes.

Acute and chronic bronchitis caused by Streptococcus Pneumonia or Haemophylus Influenzae or Moraxella CatVrhalis.

Pneumonia is suffering from a mild and medium -sized body.

has no complications caused by Neisseria Gonorrhoeae (counting the strains of beta - lactamase).

typhoid by Salmonella Typhi (including multi -resistant strains).

Sensitive shigella dysentery (including ampicillin -resistant strains). Drugs have bactericidal effects.

Cefixim's bactericidal mechanism is similar to other cephalosporins attached to target proteins (penicillin -mounted proteins that inhibit mucopeptide synthesis in bacterial cell walls).

Bacterial resistance mechanism of bacteria is to reduce the pressure of cefixim for target protein or reduce the permeability of bacterial cell membranes for drugs.

Cefixim has high durability with the hydrolysis of beta - lactamase encoded by the gene located on plasmid and chromosom. Sustainability with Cefixim's beta lactamase is higher than Cefaclor, Cefoxitin, Cefuroxim, Cephalexin, Cephradin.

pharmacokinetics

absorption:

After taking a single dose of Cefixim, only 30-50% of the dose is absorbed through the digestive tract, regardless of or after or after meals, although the absorption rate can be reduced when taken with meals.

The drug in the form of oral fluid is better absorbed in the form of tablets. The absorption of drugs is relatively slow.

The peak concentration in plasma is 2 micrograms/ml (for a dose of 20mg), 3.7 micrograms/ml (for 400mg dose) and reach after taken 2 - 6 hours.

Half lifetime in plasma is usually about 3 to 4 hours and may last for kidney failure.

Distribution:

About 65% Cefixim in the blood is attached to plasma proteins.

Information about Cefixim's distribution in tissues and fluids is limited.

Currently there is no adequate data on the concentration of drugs in cerebrospinal fluid. The drug can pass the placenta.

Era:

The drug may reach relatively high concentrations in bile and urine. About 20% of oral doses are eliminated in the form of unchanged urine within 24 hours.

There are up to 60% of oral doses without kidneys. There is no evidence of metabolism but there may be a part of the drug eliminated from the bile into the feces. The drug is not equal to the hemolysis.

Before taking Cefimbrano 100 Vidipha oral powder for infection treatment (10 packs x 2g)

How to use

Cefimbrano 100 drugs are taken orally.

Dosage

Adults: usually use 400mg/day, can be taken once or divided into 2 times 12 hours apart.

Treatment of non -complicated gonorrhea caused by Neisseria Gonorrhoeae (including beta - lactamase strains): Take 400mg (single once, coordinate with an effective antibiotic with chlamydia that is likely to be infected.

With the spread of gonorrhea, the beginning of the injection with Ceftriaxon, Cefotaxim, Ceftizoxim or Spectinomycin: Adults drink 400mg, 2 times/day, for 7 days.

Children> 12 years old or weight> 50kg: use the dose like adults.

Children 6 months - 12 years old: 8mg/kg/day, drink 1 time a day or divide 2 times, each time 12 hours apart.

Treatment time:

Depending on the type of infection, it is advisable to last 48 - 72 hours after the symptoms of infections have gone.

Normal treatment time for uncomplicated urinary tract infections and upper respiratory tract infections (if due to streptococcus group A beta hemolysis: must be treated at least 10 days to prevent heart low): 5 - 10 days, lower respiratory tract infections and medium inflammation: 10 - 14 days.

People with kidney failure:

Patients with creatinine clearance exceeding 60ml/minute: No need to adjust the dose.

Patients with creatinine clearance equal or less than 60ml/minute: Dosage and number of drug use must be adjusted depending on the degree of renal failure.

Adults have creatinine clearance 21 - 60ml/minute: 300mg/day, if the clearinine clearance is less than 20ml/minute: use the dose of cefixim 200mg/day. Because Cefixim does not disappear through hemolysis, people with dialysis and peritoneal filtering do not need to add Cefixim dose.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when overdose? Because there is no specific treatment, it is mainly symptomatic treatment.

When there is an overdose symptom, stop immediately and handle as follows: Gastroentric lavage, anti -convulsions may be used if clinical indications. Because the drug is not eliminated by hemolysis, no dialysis or peritoneal filter.

What to do when forgetting 1 dose?

Not recorded.

Side Effects

When using Cefimbrano 100, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Digestive system: diarrhea and stool, abdominal pain, vomiting, nausea, flatulence, not delicious, dry mouth. Gastrointestinal disorders usually occur in the first two days of treatment and respond to symptomatic medications, rarely stop the drug.

Nervous system: headache, dizziness, restlessness, insomnia, fatigue.

Hypersensitivity: Red rash, urticaria, drug fever.

Uncommon, 1/1000

Digestive system: severe diarrhea caused by Clostridium difficile and fake colitis.

Body: Anaphylaxis, angioedema, Steven - Johnson syndrome, diverse roses, hypertrophy are poisoned.

Hematology: A reduction of platelets, leukocytes, white blood cells, hemoglobin and hematocrite levels. liver: hepatitis and jaundice, temporary increase AST, ALT, alkaline phosphate, bilirubin and LDH.

kidney: Acute renal failure, hypernodenum nitrogen non -protein and temporary plasma creatinine levels.

Genital system: Inflammation and vaginal candidiasis.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Cefimbrano 100 contraindications in the following cases:

History of hypersensitivity to cefixim or other antibiotics of cephalosporin groups.

Anaphylactic history of penicillin.

Be cautious when using

hypersensitivity between beta -lactam antibiotics.

History of gastrointestinal diseases and colitis (when used for prolonged use can cause excessive growth of anti -drug bacteria, especially Clostridium difficile in the intestine, causing severe diarrhea).

The ability to drive and operate machinery

There is no document.

Pregnancy

There is no adequate data, so only use when really necessary.

The period of breastfeeding. Therefore, women who breastfeed are cautious when using the drug, can suspend breastfeeding during the medication.

Drug interaction

Probenecid increases the peak and AUC concentration of Cefixim, reduces the clearance of the kidneys and the distribution of the drug.

Used with anticoagulants such as warfarin increases prothrombin time, with or without bleeding.

cefixim increases carbamazepine levels in plasma when taken together.

nifedipine increases the bioavailability of cefixim when taken together, manifested by increasing peak concentration and AUC.

Storage

In a dry place, the temperature does not exceed no more than 30 ° C, avoiding light.

Other drugs

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