Cefimbrano 200mg Vidipha medicine for infections (1 blister x 10 tablets)

Dosage form Box of 1 blister x 10 tablets
Specifications Cefixim
Ingredient Vidipha

Ingredient

Composition information	Content
Cefixim	200mg

Uses

Indications

Cefimbrano 200mg drug is indicated in the following cases:

Treatment of uncomplicated urinary tract infections due to sensitive strains of E.coli or Proteus Mirabilis and a few cases due to other Gram -negative bacilli such as Citrobacter spp., Entobacter spp., Klebsiella spp. Endobacteriaceae sensitive. Pyogenes. beta - lactamase). System 3, used by oral. The drug has a bactericidal effect. Cefixim's bactericidal mechanism is similar to that of other cephalosporins attached to target proteins (penicillin -mounted proteins that inhibit mucopeptide synthesis in bacterial cell walls

Cefixim has high durability with the hydrolysis of beta - lactamase encoded by the gene located on plasmid and chromosome. Sustainability with Cefixim's beta lactamase is higher than Cefaclor, Cefoxitin, Cefuroxim, Cephalexin, Cephradin.

pharmacokinetics

After taking a single dose of Cefixim, only 30-50% of the dose is absorbed through the digestive tract, regardless of or after meals or after meals, although the absorption rate may be reduced when taken with meals. The drug in the form of oral fluid is better absorbed in the form of tablets, the absorption of the drug is relatively slow. Peak concentration in plasma is 2 micrograms/ml (for 20mg dose), 3.7 micrograms/ml (for 400mg dose) and reach after 2-6 hours. The sale time is usually about 3 to 4 and may last for kidney failure. About 65% Cefixim in the blood is close to plasma protein.

Information about Cefixim's distribution in tissues and fluid fluid is limited. Currently there is no adequate data on the concentration of cerebrospinal fluid. The drug can pass the placenta. The drug may reach relatively high concentrations in bile and urine. About 20% of oral dose is reversed in the form of unchanged urine within 24 hours. Up to 60% of oral doses are not passed through the kidneys. There is no evidence of metabolism but there may be a part of the drug eliminated from the bile into the feces. The drug is not equal to the hemolysis.

Before taking Cefimbrano 200mg Vidipha medicine for infections (1 blister x 10 tablets)

How to use

Cefimbrano 200mg medicine is taken orally.

Dosage

Adults

Usually use 400mg/day, can be taken once or divided into 2 times 12 hours apart.

Treatment of non -complicated gonorrhea caused by Neisseria Gonorrhoeae (including beta - lactamase strains): Take 400mg (single once, coordinate with an effective antibiotic with chlamydia that is likely to be infected.

With spreading gonorrhea, the beginning of the injection with Ceftriaxon, Cefotaxim, Ceftizoxim or Spectinomycin: Adults drink 400mg, 2 times/day, for 7 days.

Children> 12 years old or weight> 50kg

Dosage like adults.

Children 6 months - 12 years old

8mg/kg/day, take 1 time a day or divide 2 times, each time 12 hours apart.

Treatment time

Depending on the type of infection, it is advisable to last 48 - 72 hours after the symptoms of infections have gone. The usual treatment time for uncomplicated urinary tract infections and upper respiratory tract infections (if due to streptococcus group A beta hemolytic: must treat it for 10 days to prevent heart disease): 5 - 10 days, lower respiratory tract infections and medium inflammation: 10 - 14 days.

Renal failure

Patients with creatinine clearance more than 60ml/minute: No need to adjust the dose.

Patients with creatinine clearance are equal to or less than 60ml/minute: The dose and the number of drug use must be adjusted depending on the degree of renal failure.

Adults with creatinine clearance 21 - 60ml/minute: 300mg/day, if creatinine clearance is less than 20ml/minute; Use Cefixim doses 200mg/day. Because Cefixim does not disappear through the hemolysis, the diseases running and filtering the peritoneal do not need to add the dosage of Cefixim.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? Because there is no specific treatment, it is mainly symptomatic treatment.

When there is an overdose symptom, stop immediately and handle as follows: Gastroentric lavage, anti -convulsions may be used if clinical indications. Because the drug is not eliminated by hemolysis, no dialysis or peritoneal filter.

What to do when forgetting a dose? If it is nearly time to take the next dose, skip the forgotten dose and take medicine at the next recommended dose. Do not take double dose to compensate for the forgotten dose.

Side Effects

When using Cefimbrano 200mg, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Digestive: diarrhea and stool (27%), abdominal pain, vomiting, nausea, flatulence, not delicious, dry mouth. Gastrointestinal disorders occur in the first two days of treatment and respond to symptomatic medications, rarely stop the drug.

Nervous system: headache, dizziness, restlessness, insomnia, fatigue.

Hypersensitivity: Red rash, urticaria, drug fever.

Digestive: severe diarrhea caused by Clostridium difficile and fake colon.

Hematology: Thrombocytopenia, leukocytes, leukocytes prefer acid, reduced hemoglobin and hematocrit levels.

liver: hepatitis and jaundice: temporary increase in AST, Alt, alkaline phosphate, bilirubin and LDH.

kidney; Acute renal failure, nitrogen nitrogen nitrogen and temporary plasma creatinine levels.

Inflammation and vaginal candidiasis.

Rare, ADR

Hematology: Prothrombin time.

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Cefimbrano 200mg drug is contraindicated in the following cases:

History of hypersensitivity to cefixim or other antibiotics of Cephalosporin group.

Pre -history of counter -shock due to penicillin.

Be cautious when using

Diagonal hypersensitivity between beta - lactam antibiotics.

History of gastrointestinal diseases and colitis (when used for prolonged use can overdue resistant bacteria, especially Clostridium difficile in the intestine as heavy diarrhea).

The ability to drive and operate machinery

There is no document.

Pregnancy

There is no complete data, so only use when really necessary.

Breastfeeding period

Not sure whether Cefixim is distributed into breast milk or not. Therefore, women who breastfeed are cautious when using the drug, can suspend breastfeeding during the medication.

Drug interaction

Probenecid increases the peak and AUC concentration of Cefixim, reduces the retention of the kidney and the distribution of the drug. Carbamazepin in plasma when taken together.

Storage

In a dry place, the temperature does not exceed 30 ° C, avoiding light.

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