Cefixim 100-HV USP medicine for infection treatment (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Cefixim
Ingredient Acute bronchitis, typhoid, upper respiratory tract, chronic bronchitis, dysentery due to shigella dysenteriae

Ingredient

Composition information	Content
Cefixim	100mg

Uses

Indications

Cefixim 100 - HV is indicated for use in cases of infection with bacterial sensitivity to drugs:

The urinary tract infection is not accompanied by complications. and streptococcus pyogenes. Gonorrhoeae (including beta - lactamase). The mechanism of impact through attaching to the target protein, inhibiting the synthesis of mucopeptides in the bacterial cell wall.

antibacterial spectrum:

Gram -positive bacteria: Streptococcus pneumonia, Streptococcus pyogenes.

Gram -negative bacteria: Haemophilus Influenzae (secretive or no beta - lactamase), Moraxella Catatrhalis (most beta - lactamase secretion).

Other bacteria: Citrobacter Diversus, Escherichia Coli, Klebsiella Oxytoca, Klebsiella Pneumoniae, Proteus Mirabilis, Proteus Vulgaris, Providencia Rettgeri, Providencia Stuarti, Salmonella SP. and N. Gonorrhoeae ...

Dynamic pharmacology

cefixime is one of the very few Cephalosporin III can be used by oral.

Distribution

Cefixime is distributed into tissues and body fluids. The drug is associated with plasma protein about 65%.

Metabolism - Elimination

The half -life of the drug is about 3-4 hours in people with normal renal function and can last up to 6-11 hours in people with kidney failure. Cefixime is not metabolized in the liver and is excreted in the whole body. Therefore, the concentration of the drug in the urine is very high compared to the treatment threshold.

Before taking Cefixim 100-HV USP medicine for infection treatment (3 blisters x 10 tablets)

How to use

oral medication.

The drug is not affected by food so it can be used or not with the same food.

Dosage

as directed by your doctor or refer to the following dose:

Adults

Normal dose: 200 - 400 mg/day, once used or divided 2 times, 12 hours apart.

Uncomplicated smuggling due to Neisseria Gonorrhoeae (including beta - lactamase strain): Taking a dose of 400 mg/day (a single dose, can be combined with antibiotics).

The spread of gonorrhea: the beginning of the injection of Ceftriaxon, Cefotaxim, Ceftizoxim or Spectinomycin. When the disease is improved, treated as initially for 24 - 48 hours, then taking Cefixim 100 - HV 400 mg/time x 2 times/day, for at least 1 week.

Patients with renal failure

Should adjust the dose accordingly.

Children

Dosage recommended 8 mg/kg/day, once used or divided 2 times a day.

Children under 6 months of age: There is no data on safety and effectiveness.

From 6 months to 10 years old: use appropriate formation.

Over 10 years old or weighing over 50kg: taking the dose like adults.

Renal failure

Creatinine clearance> 60 ml/min: no dose adjustment.

Creatinine clearance is from 21 - 60 ml/minute: taking a dose of 300 mg/day.

Creatinine clearance

Radiology and peritoneal dialysis

No need for additional doses of cefixim because this substance does not lose through the hemorrhage.

Elderly

No dose adjustment.

Treatment time depends on the infection, which should be extended for 48 - 72 hours after the symptoms are gone.

Treatment time

Inhabulating urinary tract infections, upper respiratory infections from 5 to 10 days.

Lower respiratory infections and otitis media: 10 - 14 days.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Handling: Mainly symptomatic treatments such as gastric lavage, anti -convulsions may be used if necessary. Can not dialysis or abdominal filtering, because the drug is not equal to the hemolysis.

What to do when you forget 1 dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Cefixim 100 - HV, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Digestive: diarrhea, abdominal pain, nausea, vomiting, dry mouth, appetite, flatulence. Gastrointestinal disorders usually occur in the first 1-2 days of use, symptomatic treatment may be used.

Central nervous system: fatigue, insomnia, restlessness, headache, insomnia, dizziness, seizure appearance.

Hypersensitivity: Red rash, urticaria, fever. other effects: increased blood amylase levels (1.5 - 5%).

Uncommon, 1/1000

Digestive: severe diarrhea caused by Clostridioides Difficile and fake colitis.

Systemic: Evana, Stevens - Johnson syndrome, diverse roses, poisoned epidermal necrosis.

Hematology: A decrease in platelets, leukocytes, white blood cells, hemoglobin and hematocrite levels. liver: Hepatitis and jaundice, temporarily increased the bilirubin, AST, ALT, alkaline indicators, LDH. kidney: Acute renal failure, temporarily increased creatinine levels and hypercogenic blood protein.

Other cases: inflammation and vaginal candidiasis.

Rare, 1/10000

Hematology: Prothrombin time.

Body: convulsions.

Instructions on how to handle ADR

Notify the doctor with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

cefixim 100 - HV contraindicated in the following cases:

Patients with a history of allergies to cephalosporin.

Be cautious when used

use cautious use in patients with a history of disease in the gastrointestinal tract and colitis, allergic history of penicillin, other cephalosporins.

Be cautious when used for people with kidney failure, children under 6 months old.

Monitoring during the use of drugs due to the risk of some unwanted effects such as hemolytic anemia, acute kidney failure, skin reaction.

The ability to drive and operate machinery

can affect the ability to drive and operate the user's machines by side effects such as dizziness, dizziness, ...

Pregnancy

There is no complete study of the effect of the drug on pregnant women. Therefore, you should consult your doctor before taking the medication.

The period of breastfeeding

There is no solid data about whether the drug is distributed into breast milk or not. Therefore, you should consult your doctor before taking the medication.

Interactive drug

Probencid: Increasing the peak and AUC concentration of Cefixim, reducing the clearance of the kidneys, the distribution of the drug.

Warfarin (Warfarin): Increases prothrombin time, with or without bleeding.

carbamazepin: Increased plasma carbamazepine levels.

nifedipine: Increasing the peak and AUC concentration of Cefixim thus increases the bioavailability of the drug.

Cefixim can reduce the activity of typhoid vaccine.

Interaction with tests: Caodica reaction directly positively, when using Benedict, Fehling or copper Sulfate Test glucose, fake positive.

Storage

In a dry place, temperatures below 30ºC, avoid light.

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