Cefixim 200mg Cefixim cigarettes treat infections (2 blisters x 10 tablets)

Dosage form Box of 2 blisters x 10 tablets
Specifications Cefixim
Ingredient Tonsillitis, pharyngitis, otitis media, urinary tract infections, gonorrhea, pneumonia

Ingredient

Composition information	Content
Cefixim	200mg

Uses

Indications

cefixim 200mg is used to treat bacterial infections caused by sensitive bacterial strains:

Inhabited urinary tract infections caused by sensitive strains.

Middle otitis, acute and chronic bronchitis caused by Haemophilus Influenzae, Moraxella Catatrhalis, Streptococcus Pyogenes.

Sore throat and tonsils due to streptococcus pyogenes.

Mild and medium pneumonia, including the pneumonia in the community.

Invalid illegal illegal caused by neisseria gonorrhoeae (including beta-lactamase strains).

Pharmacy

cefixim is an antibiotic of the 3rd generation cephalosporin group, used by oral. Cefixim's bactericidal mechanism is similar to that of other cephalosporins attached to target proteins (penicillin -mounted proteins) that inhibit mucopeptide synthesis in bacterial cell walls. The bacterial Cefixim resistance mechanism is to reduce Cefixim's affinity for target protein or reduce the permeability of bacterial cell membranes for drugs.

Cefixim has high sustainability with the hydrolysis of beta-lactamase encoded by the gene located on plasmid and chromosom. Sustainability with beta-lactamase of Cefixim is higher than Cefaclor, Cefoxitin, Cefuroxim, Cephalexin, Cephradin.

is used in the treatment of bacterial infections caused by cefixim sensitive strains such as streptococcus sp. (Except for Enterococcus sp.), Streptococcus Pneumoniae, Neisseria Gonorrhoeae, Branhamella CatVrhalis, Escherichia Coli, Klebsiella SP., Serratia sp., Proteus sp. And Haemophilus Influenzae.

pharmacokinetics

Only 30-50% of oral dose is absorbed through the gastrointestinal tract whether taken or after or after eating, whether the food can reduce the absorption rate of Cefixim.

Half of life in plasma is about 3-4 hours and may last longer in patients with renal failure. The ratio of drugs linked to plasma protein is about 65%.

Poor distribution drugs in tissues and body fluids. The drug goes through the placenta. The drug reaches relatively high concentrations in bile and urine. About 20% of oral dose (or 50% of the absorption dose) are excreted intact through urine for 24 hours. Up to 60% of the dose of oral excretion without kidneys.

There is no evidence of metabolism but may be partially eliminated from the bile into the feces. The drug is not equal to the hemorrhage.

Before taking Cefixim 200mg Cefixim cigarettes treat infections (2 blisters x 10 tablets)

How to use

cefixim 200mg cophavina is used orally.

Dosage

Following the instructions of the physician:

Adults and children over 12 years old or weight> 50kg: Drinking 400mg/day can be used once or divided 2 times 12 hours apart.

Children> 6 months old - 12 years old recommends using Cefixim in the form of oral fluid in the dose of 8mg/kg/day, can be used once a day or divided into 2 times, each time 12 hours apart.

Unrespect the safety and effectiveness of drugs for children under 6 months of age.

Treatment time: Depending on the type of infection, it should be extended for 48 - 72 hours after the symptoms of infections have gone.

Normal treatment time for uncomplicated urinary tract infections and upper respiratory tract infections (if due to streptococcus group A, Beta blood -soluble: must treat at least 10 days of heart -low preventive prevention) from 5 to 10 days, lower respiratory infections and medium inflammation: 10 - 14 days.

For long -term uncomplicated treatment caused by Neisseria Gonorrhoeae (including Beta Lactamase secretion): Use a single dose of 400mg single, coordinate with an effective antibiotic for Chlamydia due to being likely to be infected at the same time.

For patients with renal failure:

In patients with creatinine clearance> 60ml/min, dosage and distance between the doses that can be used as usual.

The clearance of 21 - 60ml/minute or artificial dialysis can use the dose equal to 75% of the standard dose at the standard period (for example 300mg per day).

The clearance

Hematoma as well as peritoneal fertilizer does not significantly remove the drug from the body.

What to do when overdose? Because there is no specific treatment, it is mainly symptomatic treatment. When symptoms of overdose, stop immediately and handle as follows: Gastric lavage, anti -convulsions may be used if clinical indications. Because the drug is not eliminated by hemolysis, no dialysis or peritoneal filter.

What to do when forgetting 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Cefixim 200mg Cophavina may have unwanted effects such as:Common

Gastrointestinal disorders: three flows, stool, abdominal pain, vomiting, nausea, flatulence, not delicious, dry mouth.

Nervous system: headache, dizziness, restlessness, insomnia, fatigue, epilepsy.

Hypersensitivity: Red rash, urticaria, drug fever.

Less

Digestive: severe diarrhea caused by Clostridium difficile and fake colitis.

Systemic: Anaphylaxis, angioedema, Stevens-Johnson syndrome, diverse roses, poisoned epidermal necrosis. Hematology: A decrease in platelets, leukocytes, white blood cells, hemoglobin and hematocrite levels. liver: Hepatitis and jaundice, temporary increase AST, ALT, alkaline phosphatase, bilirubin and LDH. kidney: Acute renal failure, hypernodenum nitrogen non -protein and temporary plasma creatinine levels.

Vaginal candidiasis and infection.

Rare

Hematology: Prothrombin time.

Body: convulsions.

When encountering side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Cefixim 200mg Cefixim cigarette contraindicated in the following cases:

Patients with a history of allergic shock.

Hypersensitivity to any cephalosporin or penicillin or any ingredient of the drug.

Be cautious when using

Do not use with any other drugs containing cefixim.

Be cautious when taking medication in patients with renal impairment, a history of penicillin allergies, people with digestive diseases, especially fake colitis.

Serious reactions in the skin such as poisoning epidermal necrosis, Steven-Johnson syndrome, diverse Hong Ban have been reported in some patients using Cefixime. When the reaction is seriously harmful, Cefixim should be discontinued and have appropriate treatment.

Cephalosporins can cause hemolytic anemia, so be cautious in patients with a history of hemolytic anemia due to cephalosporin.

The ability to drive and operate machinery

should be careful to use the drug while operating machinery and driving because it can cause symptoms: headache, dizziness.

Pregnancy

The drug passes through the placenta and so far there is no full data research on the use of Cefixim in pregnant women, during labor and delivery. Therefore, only use Cefixim for these cases when really necessary.

Breastfeeding period

Currently, it is not yet confirmed whether Cefixim is distributed into milk in breastfeeding women. Therefore, the medication must be used carefully for breastfeeding women, which can be suspended from breastfeeding during medication.

Drug interaction

Probenecid increases the peak and AUC concentration of Cefixim, reduces the clearance of the kidney and the distribution of the drug.

anticoagulants like warfarin when used with cefixim increase prothrombin time, with or without bleeding.

Carbamazepin taken with cefixim increases carbamazepine levels in plasma.

nifedipin when taken with cefixim increases the bioavailability of cefixim manifestation of increasing peak and AUC concentration.

Storage

Leave a dry place, the temperature does not exceed 30 ° C, avoiding light.

Other drugs

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