Cefixim 400-CGP USP medicine for infection treatment (1 blister x 10 tablets)

Dosage form Box of 1 blister x 10 tablets
Specifications Cefixime
Ingredient Urinary infections, biliary fibrosis, cholecystitis, acute bronchitis, chronic bronchitis, pleura

Ingredient

Composition information	Content
Cefixime	400mg

Uses

indications

Cefixim 400 - US drug is indicated in the following cases:

Respiratory infections - ENT infections, especially otitis media caused by Haemophilus influenzae (strains with or without beta -lactamase), Moraxella Catatrhalis and S. Pyogenes. Influenzae (strains with or without beta-lactamase).

sore throat and tonsillitis. Urinary tract infections, such as cystitis, urethritis, nephritis, uncomplicated kidneys caused by Escherichia Coli and Proteus Mirabilis.

typhoid. Antibacterial spectrum includes: common bacteria in respiratory infections.

Gram+ bacteria: Streptococcus pyogenes, S. Pneumoniae.

Gram- bacteria: Gram-bacilli including beta-lactamase strains such as H. Influenzae, M. CatVrhalis. Other bacteria Citrobacter Diversus, Escherichia Coli, Klebsiella Oxytoca, Klebsiella Pneumoniae, Proteus Mirabilis, Proteus Vulgaris, Providencia Rettgeri, Providencia Stuarti, Salmonella SP., Shigella Sp. and N. Gonorrhoeae ...

The mechanism of Cefixim effect is a bactericidal that inhibits the synthesis of bacterial cell walls, so bacteria cannot create cell walls and will be broken under the effect of osmotic pressure. The outstanding advantage of Cefixim is that it has a strong effect on gram-negative bacteria and durable drugs with β-lactamase yeast of bacteria, thereby avoiding drug resistance.

Dynamic pharmacology

cefixim is one of the very few Cephalosporin II can be used by oral.

Cefixim is distributed into tissues and body fluids. The drug is associated with plasma protein about 65%.

The half -life of the drug is about 3-4 hours in people with normal renal function and can last up to 6 - 11 hours in kidney failure.

Cefixim is not metabolized in the liver and is excreted in the whole body. Therefore, the concentration of the drug in the urine is very high compared to the treatment threshold.

Before taking Cefixim 400-CGP USP medicine for infection treatment (1 blister x 10 tablets)

How to use

Take oral, drink whole tablets.

Dosage

conventional treatment time 7-14 days.

Adults and children over 12 years old

Adult treatment dose is 400 mg/day in case of severe infection, can be used once or divided into 2 times a day.

Children from 6 months to 12 years old

Treatment dose of children from 6 months to 12 years old is 8 mg/kg/day, only 1 time or divided into 2 times a day. The safety and effectiveness of Cefixim has not been recorded in children under 06 months old.

Children over 50 kg

Use as a dose for adults.

People with renal failure

Cefixim can be used in people with renal failure.

Using normal doses for patients with 60 ml/minute creatinine clearance or higher.

Patients with clearance of 21 - 60 ml/minute or artificial dialysis may take the dose of 300 mg/day with the dosage distance as usual. Patients with clearance of

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? Because there is no specific treatment, it is mainly symptomatic treatment. When symptoms of overdose, immediately stop the drug and handle as follows: Gastric lavage, anti -convulsions may be used if clinical indications. Because the drug is not eliminated by hemolysis, no dialysis or peritoneal filter.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Cefixim 400 - US drug, you may experience unwanted effects (ADR).

Cefixim is well tolerated, the side effects are usually light and can be restored after stopping the medication.

Common

Digestive: common symptoms are diarrhea and stool, abdominal pain, vomiting, nausea, flatulence, not delicious, dry mouth. Gastrointestinal disorders usually occur on the first 1-2 days of treatment and respond to symptomatic medications, rarely stop the drug.

Central nervous system: headache and dizziness, restlessness, insomnia, fatigue.

Hypersensitivity: Red rash, urticaria, drug fever.

Less

Digestive: severe diarrhea caused by Clostridium difficile and fake colitis. Body: Evaluation reaction, Stevens Johnson syndrome, diverse roses, poisoned epidermal necrosis.

Hematology: A decrease in platelets, leukocytes, white blood cells, hemoglobin and Hernatocrit levels. liver: hepatitis and jaundice, temporary increase AST, ALT, alkaline phosphatase, bilirubin and LDH. kidney: Acute renal failure, hypernodenum of blood protein and temporary plasma creatinine levels. Other symptoms: Other possible reactions include itching of the genital organs and vaginitis.

Rare

Hematology: Prothrombin time is prolonged.

Systemic: convulsions.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Cefixim 400 - US contraindicated for patients with a history of allergies to cephalosporin.

Be cautious when used

Be cautious when used for patients with a history of allergies to penicillin and other cephalosporins due to the hypersensitivity between beta-lactam antibiotics, including: penicillin, cephalosporin and cephamycin.

Be careful when using Cefixim in people with a history of gastrointestinal diseases and colitis, especially when used for prolonged use.

Dose and/or number of drugs need to be reduced in people with renal impairment.

For children under 6 months of age, so far there is no data on safety and effectiveness.

For the elderly: no dose adjustment, unless there is impaired renal function (creatinine clearance

The ability to drive and operate machinery

Because the side effects of the drug can cause dizziness, should be careful when used for drivers and operating machinery.

During pregnancy

There was no complete research on pregnant women, when studying on animals, there was no impact on the fetus. Therefore, only use the drug when really necessary. Risk of pregnancy according to FDA: level b.

The period of breastfeeding

Currently, it has not yet been confirmed that Cefixim is distributed into milk or not. Therefore, it is advisable to use medication for women who are cautious, can temporarily suspend breastfeeding during medication.

Model interaction

Be careful for patients taking anticoagulants along with Cefixim because Cefixim can increase blood clotting time.

The drug can cause fake positive reactions when testing glucose by oxidation but does not affect the enzyme reaction.

Storage

Store the drug in a dry place, temperatures below 30 ° C, avoiding light.

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