Cefovidi Vidipha powder treatment for severe infections (10 vials)

Dosage form Box of 10 vials
Specifications Cefotaxim
Ingredient Vidiphar

Ingredient

Composition informationContent
Cefotaxim1g

Uses

indications

cefovidi drugs are indicated in the following cases:

Treatment of severe bacterial infections caused by bacterial sensitivity to cefotaxim such as brain abscess, blood infection, pericarditis, meningitis (except meningitis caused by Listeria monocytogenes), pneumonia, gonorrhea, centralized treatment, severe bacterial infections in the abdominal cavity (in combination with Metronidazol) and postoperative surgery, including endoscopic surgery, including remedy surgery, including remedy.

Pharmacokology

Pharmacological group: Beta-lactam antibacterial drugs, Cephalosporin 3rd generation.

ATC code: J01DA10.

Mechanism of action: Cefotaxim has a wide antibacterial spectrum. The bactericidal effect of the drug is due to inhibiting the synthesis of bacterial cell walls. The drug is attached to one or more penicillin -mounted proteins (PBP), which are proteins involved in the composition of bacterial cell membrane structure and thus inhibits the final step of the cell biosynthesis process. The antibiotics in the group have similar antibacterial spectrums, but each drug difference in certain effects on certain bacteria. Sustainable drugs with most bacterial beta-lactamase. Compared to the cephalosporins of the first and 2nd generation, Cefotaxim has a stronger Gram -negative bacteria, but the effect on Gram -positive bacteria is weaker than the cephalosporins of the first generation. However, many streptococci are also very sensitive to cefotaxim. Desacetylcefotaxim is a metabolic substance that has the activity of cefotaxim that may add or co -work on some bacteria.

Bacteria are often sensitive to Cefotaxim: En The strains of Staphylococcus, Haemophilus influenzae, Haemophilus spp. Hydrophilia, corynebacterium diphteriae.

In Vietnam, EntroBacter Aerogenes, Salmonella Typhi, H.influenzae, Klebsiella spp. Cefotaxim resistance. Cefotaxim should be used carefully and limited to prevent the anti -drug trend of bacteria for Cefotaxim, as well as other antibiotics that are increasing.

Dynamic pharmacokinetics

The drug is absorbed very quickly after intramuscular injection. After 30 -minute injection 1g, the average peak of plasma is 20 mcg/ml. Immediately after the intravenous injection of 1g Cefotaxim, the peak of the peak plasma reaches 102 mcg/ml. The sale time of cefotaxim in plasma is about 1 hour and of activated metabolites desacetylcefotaxim about 1.5 hours. About 40% of the drug is attached to plasma proteins. Desacetylcefotiaxi's waste time is longer in newborns and in patients with severe kidney failure. Therefore, it is necessary to reduce the dosage of drugs in these objects. No need to adjust the dosage in patients with liver disease. Cefotaxim and Desacetylcefotaxim are widely distributed in tissues and fluids. The concentration of the medication in cerebrospinal fluid reaches the level of treatment, especially when meningitis. Cefotaxim passes through the placenta and has low concentrations in breast milk.

In the liver, Cefotaxim converts partially into Desacetylcefotaxim and other inactive metabolites. The drug is excreted mainly through the kidneys (within 24 hours, about 40-60% of unchanged forms are seen in urine), about 20% excreted in the form of Desacetyl metabolites. Cefotaxim and Desacetylcefotaxim are also in the bile and about 20% of the dose found in the feces. Probenecid slowed down the elimination process, so the concentrations of cefotaxim and desacethylcefotaxim in the blood and longer lasted. Can reduce the concentration of drugs with dialysis.

Before taking Cefovidi Vidipha powder treatment for severe infections (10 vials)

How to use

Injecting deep intramuscular.

Slow intravenous injection 3 - 5 minutes.

Slow intravenous injection for 20 - 60 minutes.

Use the following solutions to mix injection, infusion: aseptic water for injection, 0.9%sodium chloride, 5%dextrose, dextrose and sodium chloride, ringer lactate or 1 intravenous fluid with pH = 5 - 7.

separate cefotaxim injection, not injected with aminoglycosides or metronidazol.

Do not mix with other antibiotics in the same syringe or intravenous system.

Dosage

Usually: 2 - 6g/day, divided 2-3 times. Severe cases may increase to 12g/day, intravenous infusion 3-6 times. Poseudomonas Aeruginosa (Pseudomonas): Over 6g/day.

Children: 100 - 150mg/kg body weight/day (infant: 50mg/kg), divided 2-4 times. If necessary, it can be increased to 200mg/kg (babies 100 - 150mg/kg).

People with severe renal failure (Creatinine clearance below 10ml/minute): Reduce the dose half of the initial attack dose, keeping the number of times used in the day, the maximum dose of 2g/day.

Gonorrhea: using a single dose 1g.

Prevention of postoperative infection: 1g injection before surgery from 30 - 90 minutes. Caesarean section: Intravenous mother after the stalks; After 6 - 12 hours of injecting 2 more doses into corn or veins.

Treatment time: Continuing 3-4 days after the body temperature has returned to normal or certainly killed all bacteria.

For bacterial infections caused by bacterial bacterial bacterial bacteria group A: Use at least 10 days. Persistent infections: Sometimes for weeks.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? Cefotaxim should be stopped and replaced with an antibiotic with clinical effects on c. Difficile (such as Metronidazol, Vancomycin).

How to handle the overdose: If there is a symptom of poisoning, it is necessary to stop Cefotaxim immediately and take the patient to the hospital for treatment. The abdominal separation or dialysis can reduce the concentration of cefotaxim in the blood.

In case of emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double doses to compensate for missed dose.

Side Effects

When using Cefovidi drugs may experience unwanted effects (ADR) such as:

Common: (1/100

  • Digestive: diarrhea, vomiting, nausea, colitis
  • Blood: Eosin leukopenia or leukopenia generally makes Test Coombs positive.
  • Systemic body: Anaphylaxis, hypersensitivity reactions.

    Notify the physician with unwanted effects when using the drug.

    • Warnings

    Before using the drug you need to read the instructions carefully and refer to the information below.

    Contraindicated

    Cefovidi drugs contraindicated in the following cases:

  • Sensitive people with Cefotaxim or other cephalosporin.

    • Be cautious when using

    need to be very careful when taking the drug for patients in the following cases:

    Before starting treatment with cefotaxim, a thorough investigation of the patient's allergic history with cephalosporin, penicillin or other drugs.

    There is a cross -allergy between penicillin and cephalosporin in 5 - 10% of cases, must be very careful when using cefotaxim for patients with penicillin allergies.

    Monitor kidney function test if used simultaneously with toxic drugs with kidneys (for example, aminoglycosides). Cefotaxim can cause false positive with test coombs, with urinary tests, with reducing agents without using enzymes.

    Dosage reduction for patients with severe kidney failure.

    Taking long -term medication may have fungal or bacterial infections, including diarrhea due to clostridium difficile infection and fake membrane inflammation.

    Caution for patients with a history of convulsions; Especially in patients with renal failure without decreased dose, due to increased risk of convulsions.

    If convulsions occur during treatment with cefotaxim, the drug must be stopped and should be indicated for anti -convulsions.

    The effect of the drug on the ability to drive and operate machinery

    should be cautious because the drug can cause dizziness, convulsions.

    Use drugs for women during pregnancy and lactation

    Pregnancy

    Not notice the teratogenic effect in experimental animals. However, safety for pregnant women has not been determined. Only use cefotaxim for pregnant people when really necessary.

    Breastfeeding period

    Can use cefotaxim with nursing mothers but must be concerned when children have diarrhea, so, rash. Be careful, best to avoid use.

    Drug interaction

    Increased risk of kidney damage when used in combination with colistin.

    Concentrated with azlocilin in people with renal failure: may have brain disease and local epilepsy.

    Reducing Cefotaxim's clearance when used with ureaido - penicillin (azlocilin or mezlocilin), the dose of cefotaxim must be reduced if shared.

    Increase the toxic effect of cyclosporin's kidneys when shared.

    Simultaneous use of aminoglycosides can increase the risk of toxicity to the kidneys during treatment.

    Probenecid reduces Cefotaxim's clearance.

    The activity of Cefotaxim may increase when used simultaneously with urinary urinary agents.

    Cefotaxim can reduce the activity of typhoid vaccine.

    The cavalry of the drug:

    Cefotaxim is not compatible with alkaline solutions such as sodium bicarbonate solution.

    separate cefotaxim injection, not injected with aminoglycosides or metronidazol.

    Storage

    Leave a cool place, avoid light, temperatures below 30⁰C.

    To be out of reach of children, read the instructions carefully before use.

    Other drugs

    Disclaimer

    Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

    The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

    count views

    Popular Keywords