Cefpobiotic 200mg Medipharco medicine for infection treatment (2 blisters x 10 tablets)

Mild and medium -sized urinary tract infections, no complications (cystitis) caused by sensitive strains E.coli, Klebsiella Pneumonidae, Proteus Mirabilis or Staphylococcus Saprophytius.

Excessive gonorrhea infections have complications, cervical endothelial or rectal anus of women and gonorrhea in the urethra of women and men, due to strains or no penicillinase of Neisseria Gonorrhoe.

Pharmacology

cefpodoxim inhibits cell wall synthetic bacteria by attaching to proteins attached to penicillin (Pbps). This leads to the disruption of the biosynthesis of the cell wall (peptidoglycan), leading to the destruction of bacterial cells and die.

Bacterial antibiotic antibiotic antibiotic mechanism of bacteria:

cefpodoxim is the 3rd generation cephalosporin antibiotic that has the power for Gram -positive bridges such as pneumococcal (streptococcus pneumoniae), streptococcus streptococcus (streptococcus) group A, B, C, G and with staphococcus aureus, staphyloccus Epidermidis whether or not produces beta-lactamase. However, the drug has no anti-staphylococcus staphylococcus a staphylococcus staphylococcus a staph with isoxazole-penicillin due to changes in penicillin-mounted proteins (the type of resistance of methicillin-resistant staphylococcus aureus). This MRSA antibiotic resistance is growing in Vietnam.

Cefpodoxim also works for Gram -negative bacteria, Gram -positive and gram -negative bacilli. The drug has anti -gram -negative anti -bacteria such as E. Coli, Klebsiella, Proteus Mirabilis and Citrobacter.

However, in Vietnam, these bacteria are resistant to cephalosporin 3rd generation. This problem should be noted because it is the risk of failure in treatment.

In contrast to other oral cephalosporins, sustainable cefpodoxim for beta-lactamase caused by Haemophilus Influenzae, Moraxella Catatrhalis and Neisseria. However, this comment has not been monitored with systems in Vietnam and the activity of Cefpodoxim is higher than the activity of other oral cephalosporins.

Cefpodoxim has little effect on Proteus vulgaris, Entratia, Serratia Marcesens and Clostridium Perfringens. These bacteria are sometimes completely resistant.

Staphylococcus a staphylococcus of methicilin, Staphylococcus Saprophyticus, Enterococcus, Pseudomondas Aeruginosa, Pseudomonas spp Completely cephalosporin.

pharmacokinetics

absorption:

Cefpodoxim Proxetil is absorbed through the gastrointestinal tract, the absorption increases when present of food and decreases when the stomach pH is low.

Film baggage tablets and biological oral media are equivalent to biology. Cefpodoxim has a pharmacokinetic dependent, linear with a dose of 100-400 mg, not linear when the dose is over 400mg.

The drug does not accumulate in plasma after taking multiple doses (up to 400mg, 12 hours/time) in people with normal kidney function. The pharmacokinetics of Cefpodoxim are not affected in patients with liver failure, but are affected by kidney failure. The bioavailability of Cefpodoxim is about 50% in people who have not eaten. Increasing bioavailability when used with food.

Distribution:

The average distribution of Cefpodoxim is about 0.7-1.15 l/kg in healthy adults with normal kidney function. About 20-30% Cefpodoxim binds to plasma proteins.

cefpodoxim well distributed into the tissue of the lungs and throat, into the pleural fluid; The drug in cerebrospinal fluid is very small and a small amount appears in milk, the drug is achieved in respiratory, urinary and bile.

Metabolism:

After taking a dose of Cefpodoxim, healthy people have normal kidney function, plasma peak concentration is reached within 2-3 hours and have an average value of 1.4 micrograms/ml; 2.3 micrograms/ml; 3.9 micrograms/ml corresponding to doses of 100 mg, 200 mg, 400 mg Cefpodoxim; 8 hours after use with the above dose, the average plasma concentration is 0.29; 0.62; 1.3 micrograms/ml.

Cefpodoximimim Proxetil is metabolized by non -specific esters in the intestine into a metabolic cefpodoxim metabolitus. The half-life in the serum of Cefpodoxim is about 2-3 hours for patients with normal renal function and prolonged in patients with renal impairment.

Era:

The drug is excreted mainly through the kidneys (about 80% in the form of non -changing drugs within 24 hours). No biological and liver transformations occur.

The drug is eliminated about 23% of the unique oral dose in 3 hours of hemorrhage.

ears: tinnitus.

Skin and subcutaneous tissue: Hypersensitivity reaction, rash, urticaria, itching.

rare, ADR

There is a history of allergies or anaphylaxis with penicillin or other beta-lactam antibiotics.

Be cautious when using

cefpodoxim is not a priority antibiotic to treat staphylococcus aureus pneumonia and should not be used in the treatment of pneumonia is not typical caused by organisms like Legionella, Mycoplasma and Chlamydia. Cefpodoxim is not recommended for the treatment of pneumes caused by S. Pneumoniae.

As with all beta-lactam antibiotics, serious hypersensitivity reactions have been reported. In case of severe hypersensitivity reactions, cefpodoxim treatment must be stopped immediately and emergency support measures must be taken.

In case of severe renal failure, the dose must be reduced depending on the clearine clearance.

Fake colitis and fake colitis associated with antibacterial effects have been reported with almost all anti -bacterial agents, including Cefpodoxim, and the severity of mild to life -threatening. Therefore, it is important to consider this diagnosis in patients with diarrhea in or after treatment with cefpodoxim.

Discontinue treatment with Cefpodoxim and specific treatments for Clostridium difficile should be considered. Do not use intestinal inhibitors.

Cefpodoxim should be prescribed carefully in patients with a history of gastrointestinal diseases, especially colitis.

Similar to all beta-lactam antibiotics, leukemia and rarely losing granulocytes can occur, especially during prolonged treatment. In case of radio treatment for more than 10 days, blood formula should be monitored and stopped if leukopenia occurs.

cephalosporin can cause fake positive tests. Cross -reactions with penicillin may take place.

Changes in the renal function have been recorded with cephalosporin antibiotics, especially when taken simultaneously with drugs that are potentially toxic to the kidneys such as aminoglycosides and/ or diuretics. In this case, kidney function should be monitored.

As with other antibiotics, the prolonged use of Cefpodoxim can lead to excessive development of non -sensitive organisms (Candida and Clostridium difficile), if the resistance occurs, it is necessary to stop treatment.

In the formula contains ingredients: ponaceau color, tartazin color, Sunset Yellow color capable of causing allergies.

The ability to drive and operate machinery

dizziness has been reported during treatment with Cefpodoxim and can affect the ability to drive, use machinery and work on high.

Pregnancy

There is no document about using Cefpodoxim during pregnancy. However, cephalosporins are often considered safe when used for pregnant women.

Breastfeeding period

cefpodoxim is excreted in breast milk with low concentrations. Despite low concentrations, there are still 3 problems that will occur with breastfed children with cefpodoxim: Disorders of intestinal bacteria, directly acting to the child's body and bacterial culture results will be wrong if they have to make antibiotics when fever.

Therefore, it is necessary to be cautious when using cefpodoxim for breastfeeding women, should consider stopping breastfeeding during cefpodoxim treatment and used under the doctor's instructions.

Drug interaction

Avoid using Cefpodoxim with antacids and H2 resistance because of reducing the absorption of Cefpodoxim.

Avoid using cefpodoxim along with probenecid because probenecid reduces the elimination of cephalosporin.

Cephalosporin has the ability to increase coagulopathy of COMAARS and reduce the contraceptive effect of the estrogens.