Cefpodoxim 100-HV USP oral powder for infection treatment (10 packs x 3g)

Dosage form 10 package box
Specifications Cefpodoxim
Ingredient Tonsillitis, pharyngitis, otitis media, urinary tract infections, acute bronchitis, gonorrhea, chronic bronchitis, pneumonia

Ingredient

Composition information	Content
Cefpodoxim	100mg

Uses

indications

cefpodoxim 100-HV drug is indicated in the following cases:

Treatment of mild to medium diseases in the lower respiratory tract, including acute pneumonia is acquired in the community due to strains of streptococcus pneumoniae or haemophilus influenzae sensitive (including semi -born Beta - lactamase), acute phase of the racial bronchitis caused by sensitive S. Pneumoniae strains and caused by H. Influenzae or MorameLLA or Mormae (Branhamella, formerly called Neisseria) CatVrhalis, did not produce beta - lactamase.

Treatment of mild and medium infections in the upper respiratory tract (for example, sore throat, tonsillitis) due to sensitive streptococcus pyogenes, cefpodoxim is not a priority selected drug, but rather a substitute for the main treatment (eg penicillin).

Cefpodoxim also plays a role in the treatment of acute otitis media caused by sensitive strains S. Pneumoniae, H. Influenzae (including the strains of Beta - Lactamase) or B. CatVrhalis.

Treatment of mild and medium -sized urinary tract infections, unprovenes (cystitis) caused by sensitive strains E. coli, klebsiella pneumoniae, proteus mirabilis or staphylococcus saprophyticus.

A single dose of 200 mg of Cefpodoxim is used to treat acute gonorrhea, inconstatable, endothelial cervical or anus - rectum of women and gonorrhea in the urethra of women and men, due to strains or non -penicillinase of Neisseria Gonorrhea.

Treatment of mild infections to fit skin complications and skin organizations caused by staphylococcus aureus created or not producing penicillinase and sensitive strains of streptococcus pyogenes.

Pharmacokology

Cephalosporin antibiotic 3rd generation.

ATC code: J01DD13.

Cefpodoxim is a 3rd generation cephalosporin antibiotic. In countries with low antibiotic resistance ratio, Cefpodoxim has a high sustainability of the attack of beta - lactamase, caused by Gram -negative and gram -positive bacteria.

In principle, Cefpodoxim has the force of Gram -positive bridge such as streptococcus pneumoniae), streptococcus streptococcus streptococcus (streptococcus) groups A, B, C, G and with staphylococcus aureus, S. Epidermidis or not producing beta - lactamase. However, the drug has no anti -staphylococcus staphylococcus aureus - penicillin due to changes in penicillin -mounted proteins (the type of resistance of methicilin staphylococcus augmentation MRSA). This MRSA antibiotic resistance is growing in Vietnam.

Cefpodoxim also works for Gram -negative bacteria, Gram -positive and gram -negative bacilli. The drug has anti -gram -negative anti -bacteria such as E. Coli, Klebsiella, Proteus Mirabilis and Citrobacter.

However, in Vietnam, these bacteria are also resistant to cephalosporin 3rd generation. This issue should be noted because it is a risk of failure in treatment.

In contrast to other oral cephalosporins, sustainable cefpodoxim for beta - lactamase due to Hae -mophilus influenzae, moraxella catatrhalis and neisseria born. However, this comment has not been monitored with systems in Vietnam and the activity of Cefpodoxim is higher than the extent compared to the activity of other oral cephalosporins.

Cefpodoxim has little effect on Proteus vulgaris, Entratia, Serratia Marcesens and Clostridium Perfringens. These bacteria are sometimes completely resistant.

Staphylococcus a staphylococcus of methicilin, Staphylococcus Saprophyticus, Enterococcus, Pseudomonas Aeruginosa, Pseudomonas spp All cephalosporins.

Dynamic pharmacokinetics

cefpodoxim is a cefpodoxim proxetil oral drug (ester of cefpodoxim). Cefpodoxim Proxetil has little antibacterial effect when not hydrolyzed into cefpodoxim in the body. Cefpodoxim Proxetil is absorbed through the gastrointestinal tract and is metabolized by non -specific esters, maybe in the intestinal wall, the metabolic cefpodoxim metabolites work.

Biology of Cefpodoxim is about 50%. This biological use increases when using Cefpodoxim with food. The half -life of Cefpodoxim is 2.1 - 2.8 hours for patients with normal kidney function. Half of the serum increases to 3.5 - 9.8 hours in people with kidney disabled. After taking a dose of Cefpodoxim, in healthy adults has a normal renal function, plasma peak concentration is reached within 2-3 hours and has an average value of 1.4 µg/ ml, 2.3 µg/ ml, 3.9 µg/ ml for doses of 100 mg, 200 mg, 400 mg.

about 40% Cefpodoxim binds to plasma proteins. The drug is eliminated in the form of non -change through the filter of the glomerular and excretion of the renal tubules. About 29 - 38% of the dose is eliminated within 12 hours in adults with normal kidney function. There is no biological change in the kidneys and liver. The drug is eliminated to a certain extent when the hemorrhage.

Before taking Cefpodoxim 100-HV USP oral powder for infection treatment (10 packs x 3g)

How to use

Use oral, pour all the dough in the package into the cup to add about 5 ml of water, stir and then immediately drink the obtained mixture.

Dosage

Adults and children over 13 years old:

To treat the acute phase of chronic bronchitis or mild acute pneumonia to the community, the common dose of Cefpodoxim is 200 mg/ time, every 12 hours, in 10 or 14 days.

For pharyngitis and/or mild tonsillitis to fit or infection of mild or mild urinary tract bacteria, which are not complicated with the dose of cefpodoxim is 100 mg every 12 hours, for 5-10 days or 7 days, respectively.

For skin infections and mild and medium -sized skin organizations, unprecedented, the common dose is 400 mg every 12 hours, for 7-14 days.

To treat unprocessed urethral gonorrhea in men, women and gonorrhea - rectal and endothelial cervix in women: using a single dose of 200 mg of cefpodoxim, followed by oral doxyclin treatment to prevent chlamydia infection.

Children:

To treat acute otitis media in children from 5 months to 12 years old, take a dose of 5 mg/ kg (maximum 200 mg) Cefpodoxim every 12 hours, or 10 mg/ kg (maximum 400 mg) once a day, for 10 days.

To treat bronchitis/ mild and moderate tonsillitis in children 5 months to 12 years old, the common dose is 5 mg/ kg (maximum 100 mg) every 12 hours, for 5-10 days.

To treat other infections for children under 15 days of age: Do not use.

From 15 days to 6 months: 8 mg/ kg/ day, divided 2 times;

From 6 months to 2 years: 40 mg/time, 2 times a day;

From 3 years old to 8 years old: 80 mg/time, 2 times a day;

Over 9 years: 100 mg/time, 2 times a day.

Dose for kidney failure:

Must decrease depending on the degree of renal failure. For patients with creatinine clearance less than 30 ml/ min, and no blood separation, common dose, for each 24 hours apart. Patients are taking blood apart, taking the dose often 3 times/ week.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Overdose:

Overdose for Cefpodoxim Proxetil has not been reported.

Symptoms of overdose may include nausea, vomiting, epigastric pain and diarrhea.

How to handle:

There is no specific antidote, in case of an overdose, the stomach should be carried out to eliminate the absorbed part of the drug from the body. However, the main treatment of overdose is supporting or resolving symptoms

In case of severe poisoning reactions due to overdose, hemolysis or peritoneal fertilizer can help remove Cefpodoxim from the body, especially when the kidney function is impaired.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using Cefpodoxim 100-HV, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Digestive: Nausea, vomiting, diarrhea, abdominal pain.

general: headache. allergic reaction: rash, urticaria, itching.

Uncommon, 1/1000

Allergic reactions: Reaction such as serum with rash, fever and joint pain and anaphylactic reaction.

Skin: Diverse erythema.

liver: liver enzyme disorders, hepatitis and temporary jaundice.

Rare, ADR

Blood: hyperphaulocytes like eosin, blood disorders.

kidney: interstitial nephritis has recovery.

Central nervous system: Increase activity, be agitated, have difficulty sleeping, confuse, increase tone and dizziness dizziness.

Instructions on how to handle ADR:

Cefpodoxim stop treatment.

Notice the doctor unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindications:

Cefpodoxim 100-HV drug is contraindicated in the following cases:

Patients with allergies to cephalosporins;

Porphyrin metabolic disorders.

Be cautious when using

Before starting treatment with cefpodoxim, a thorough investigation of the patient's allergic history with cephalosporin, penicillin or other drugs.

Need to use cautious for people who are sensitive to penicillin, kidney and pregnant or nursing mothers.

The ability to drive and operate machinery

There has been no report on the effect of drugs when used for drivers and operating machinery.

Pregnancy

There is no document about using Cefpodoxim during pregnancy. However, cephalosporins are often considered safe when used for pregnant women.

breastfeeding period

cefpodoxim is secreted through low concentrations. Despite low concentrations, there are still 3 problems that will occur for breastfed children with cefpodoxim: Disorders of intestinal bacteria, directly acting to the child's body and bacterial culture results will be wrong, if antibiotic when fever.

Drug interaction

Cefpodoxim absorption is reduced when there is anti -acid, so avoid using cefpodoxim along with anti -acid.

Storage

Store the drug in a dry, airy place, temperatures below 30 ° C, avoiding light.

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