Cefpodoxim 200mg-HV USP medicine for infection treatment (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Cefpodoxim
Ingredient Tonsillitis, otitis media, sinusitis, skin and soft tissue infections, gonorrhea, upper respiratory tract, pneumonia

Ingredient

Composition information	Content
Cefpodoxim	200mg

Uses

Indications

cefpodoxim is used in oral form to treat mild to medium diseases in the lower respiratory tract, including acute pneumonia with the community due to streptococcus pneumoniae or Haemophilus influenzae sensitive (including the strains of the Beta - Lactamase) Due to the strains s. Pneumoniae is sensitive and caused by Influenzae or Moraxella (Branhamella, formerly known as Neisseria) CatVrhalis, does not produce beta - lactamase.

To treat mild and medium infections in the upper respiratory tract (for example, sore throat, tonsillitis) due to sensitive streptococcus pyogenes, cefpodoxim is not a priority selected drug, but rather a replacement drug for the main treatment (eg penicillin).

Cefpodoxim also plays a role in the treatment of acute otitis media caused by sensitive strains S. Pneumoniae, H. Influenzae (including the strains of Beta - Lactamase) or B. CatVrhalis. Cefpodoxim is also used to treat mild and medium -sized urinary tract infections, without complications (cystitis) caused by sensitive strains E. coli, Klebsiella Pneumoniae, Proteus Mirabilis, or Staphylococcus Saprophyticus.

A single dose of 200mg of Cefpodoxim is used to treat acute, unprocessed gonorrhea, cervical or anus - rectal of women and gonorrhea in the urethra of women and men, due to the strains with or no penicillinase of Neisseria Gonorrhea.

Cefpodoxim is also used to treat mild infections that have no complications in the skin and skin organizations caused by Staphylococcus aureus created or not producing penicillinase and sensitive strains of streptococcus pyogenes.

Read the instructions carefully before use. If you need more information, please consult your doctor. This drug is only used as prescribed by a physician.

Pharmacology

cefpodoxim is the 3rd generation cephalosporin antibiotic. In countries with low antibiotic resistance rates, Cefpodoxim has high stability against the attack of beta - lactamase, caused by negative grams and grams.

In principle, Cefpodoxim has the force of gram -positive bridge such as pneumococcus (streptococcus pneumoniae), streptococcus streptococcus streptococcus (streptococcus streptococcus (streptococcus) group A, B, G and with staphylococcus aureus, S. Epidermidis or not producing beta - lactamase.

However, the drug has no anti -staphylococcus effects against isoxazolel - penicillinmdo changes protein with penicillin (the resistance type of methicilin -resistant staphylococcus MRSA). This MRSA antibiotic type is growing in Vietnam.CEFPodoxim also works for Gram -negative bacteria, Gram -positive and gram -negative bacilli.

The drug has anti -gram -negative bacteria such as E. Coli, Klebsiella, Proteus Mirabilis and Citrobacter. However, in Vietnam, these bacteria are also resistant to cephalosporin 3rd generation. This issue should be noted because it is a risk of failure in treatment. In contrast to other oral cephalosporins, sustainable cefpodoxim for beta - lactamase by Haemophilus Influenzae, Moraxella Catatrhalis and Neisseria.

However, this comment has not been monitored with a system in Vietnam and the activity of Cefpodoxim is higher than that of other Porin oral. Cefpodoxim has little effect on Proteus Vulgaris, Entobacter, Serratia Marcesens and Clostridium Perfringens, these bacteria are sometimes completely resistant.

Staphylococcus a staphylococcus of methicilin, Staphylococcus Saprophyticus, Enterococcus, Pseudomonas Aeruginosa, Pseudomonas spp All cephalosporins.

pharmacokinetics

cefpodoxim on the market is the form of oral cefpodoxim Proxetil (ester of cefpodoxim). Cefpodoxim Proxetil has little antibacterial effect when not hydrolyzed into cefpodoxim in the body. Cefpodoxim Proxetil is absorbed through the gastrointestinal tract and is metabolized by non -specific esters, maybe in the intestinal wall, the metabolic of Cefpodoxim metabolites works.

Biology of Cefpodoxim is about 50%. This biological use increases when using Cefpodoxim with food. The half -life of Cefpodoxim is 2.1 - 2.8 hours for patients with normal kidney function.

Half of the serum increases to 3.5 - 9.8 hours in people with kidney disabled. After taking a dose of Cefpodoxim, in healthy adults has a normal kidney function, plasma peak concentration is reached within 2-3 hours and has an average value of 1.4 micrograms/ml, 2.3 micrograms/ml, 3.9 micrograms/ml for doses of 100mg, 200mg, 400mg.

about 40% Cefpodoxim binds to plasma proteins. The drug is eliminated in the form of non -change through the filter of the glomerular and excretion of the renal tubules. About 29 - 38% of the dose is eliminated within 12 hours in adults with normal kidney function. There is no biological change in the kidneys and liver. The drug is eliminated to a certain extent when the hemorrhage.

Before taking Cefpodoxim 200mg-HV USP medicine for infection treatment (3 blisters x 10 tablets)

How to use

Oral drugs.

Dosage

Adults and children over 13 years old

To treat the acute phase of chronic bronchitis or mild acute pneumonia to the community, the common dose of Cefpodoxim is 200mg/time, every 12 hours, in 10 or 14 days.

For sore throat and/or mild tonsillitis to medium or mild or mild urinary tract infections, Cefpodoxim dose is 100mg every 12 hours, for 5-10 days or 7 days, respectively.

For skin infections and mild and medium -sized skin organizations, the common dose is 400mg every 12 hours, for 7-14 days.

To treat unpopular gonorrhea in men, women and gonorrhea - rectal and endothelial cervix in women: use a single dose of 200mg Cefpodoxim, followed by oral doxyclin treatment to prevent chlamydia infection.

Children

To treat acute otitis media from 5 months to 12 years old, take a dose of 5mg/kg (maximum 200mg) Cefpodoxim every 12 hours, or 10mg/kg (maximum 400mg) once a day, for 10 days. To treat bronchitis/tonsillitis mild and medium in children 5 months to 12 years old, the usual dose is 5mg/kg (maximum 100mg) every 12 hours, for 5-10 days.

To treat other infections for children under 15 days of age: Do not use.

From 15 days to 6 months: 8mg/kg/day, divided 2 times.

From 6 months to 2 years: 40mg/time, 2 times a day.

From 3 years old to 8 years old: 80mg/time, 2 times a day.

over 9 years old: 100mg/time, 2 times a day.

Dosage for people with renal failure

must be reduced depending on the degree of renal failure. For patients with creatinine clearance less than 30ml/ min, and no blood separation, common dose, for each 24 hours apart. Patients are taking blood apart, taking the usual doses 3 times/week. Symptoms due to overdose medication may include nausea, vomiting, epigastric pain and diarrhea.

In case of severe poisoning reactions due to overdose, hemolysis or peritoneal can help remove Cefpodoxim from the body, especially when the kidney function is impaired.

What to do when forgetting 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Cefpodoxim 200mg, you may experience unwanted effects (ADR).

Common

Digestive: Nausea, vomiting, diarrhea, abdominal pain.

general: headache. allergic reaction: rash, urticaria, itching.

Less

Allergic reactions: Reaction such as serum with rash, fever and joint pain and anaphylactic reaction.

Skin: Diverse erythema.

liver: liver enzyme disorders, hepatitis and temporary jaundice.

Rare

Blood: hyperphaulocytes like eosin, blood disorders.

kidney: interstitial nephritis has recovery. Central nervous system: Increase activity, be agitated, have difficulty sleeping, confuse, increase tone and dizziness dizziness.

When encountering side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Cefpodoxim 200mg drug is contraindicated in the following cases:

Patients with allergies to cephalosporins.

Porphyrin metabolic disorders.

Be cautious when using

Before starting treatment with cefpodoxim, a thorough investigation of the patient's allergic history with cephalosporin, penicillin or other drugs.

Need to use cautious for people who are sensitive to penicillin, kidney and pregnant or nursing mothers.

The ability to drive and operate machinery

should be careful to use the drug while operating machinery and driving because it can cause symptoms: headache, dizziness.

Pregnancy

There is no document about using Cefpodoxim during pregnancy. However, cephalosporins are often considered safe when used for pregnant women.

Breastfeeding period

cefpodoxim is secreted in breast milk with low concentrations. Despite low concentrations, there are still 3 problems that will occur for breastfed children with cefpodoxim: Disorders of intestinal bacteria, directly acting to the child's body and bacterial culture results will be wrong, if antibiotic when fever.

Medicinal interaction

Cefpodoxim absorption is reduced when acidic, so avoid using cefpodoxim along with anti -acid.

Storage

Store drugs in a dry place, temperatures below 30 ° C, avoiding light.

To be out of reach of children.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.