Cefprozil 250-UST Treatment of infection (1 blister x 10 tablets)

Dosage form Box of 1 blister x 10 tablets
Specifications Cefprozil
Ingredient USP

Ingredient

Composition information	Content
Cefprozil	250mg

Uses

Indications

Cefprozil 250-UST is indicated in the following cases:

Treatment Mid-inflammatory disease acute.

Treatment sore throat , tonsillitis. Moraxella Catatrhalis (including beta-lactamase production strains). Calculated by S. Pneumoniae, H. Influenzae (including beta-lactamase production strains), or M. CatVrhalis (including beta-lactamase production strains). Disclosure. Under the hydrolysis of beta lactamase, Cefprozil is more stable than Cefaclor.

Cefprozil has the following anti-bacterial effects: Gram-aerobic grams: Staphylococcus aureus (including beta-lactamase production strains), Streptococcus Pneumonia, Streptococcus Pyogenes, Enterococcus Dans, Enterococcus Faecalis, Listeria monocytogenes, Monocytogenes, Listeria monocytogenes Staphylococcus Epidermidis, Staphylococcus Saprophyticus, Staphylococcus Wameri, Streptococcus Agalactiae, monkeptococci (group C, D, F, and G).

Note: Cefprozil does not work on Staphylococci, Enterococcus Faecium Methicillin resistance, and most of acinetobacter, Entobacter, Morganella Morganii, Proteus Vulgaris, Providacia, Pseudomonas and Serratia.

Aerobic grams: Haemophilus Influenza (including beta-lactamase production strains), Moraxella (Branhamellà) CatVrhalis (including beta-lactamase production strains), Citrobacter Diversus, Escherichia coli, Klebsiella Pneumonia, Neensseria (Including beta-lactamase production strains), Proteus Mirabilis, Salmonella spp., Shigella spp., Vibrio spp.

Anaerobic bacteria: Prevotella (Bacteroides) Melaninogenicus, Clostridium difficile, Clostridium perfringens, Fusobacterium spp., Peptostreptoccus spp., Propionibacterium acnes.

Note: Most strains of the Bacteroides Fragilis group are resistant to Cefprozil.

pharmacokinetic

absorption

After drinking, Cefprozil is quickly absorbed through the gastrointestinal tract. Birth in adults is about 90 - 95%, the peak concentration of plasma is about 1.5 hours. Food does not affect the absorption and peak concentration of plasma, but the time to reach the peak concentration in plasma can last 15 - 45 minutes.

Distribution

The drug is distributed into tissues and fluid including gastric juice, middle ear fluid, tonsils and adenoidal tissues (V.A). The drug is distributed into milk at low concentrations. About 35 - 45% Cefprozil in the circulatory system linked to plasma proteins. Half of the drug in plasma is about 1 - 1.4 hours in adults with normal kidney function. Children 6 months to 12 years old, half -life of plasma in plasma is about 0.94 - 2.1 hours.

Elimination

Cefprozil is excreted through the filtered urine in the glomerular filter and excreted in the renal tubules. About 54 - 70% of the doses of use are eliminated in urine in the form of unchanged within 24 hours.

Before taking Cefprozil 250-UST Treatment of infection (1 blister x 10 tablets)

How to use

Take oral use. Dosage and duration of drug use for each specific case as directed by the treating doctor.

Dosage

Adults:

Acute otitis media: 500mg every 12 hours for 10 days.

Sore throat or tonsillitis: 500 mg x 1 time/day for 10 days.

Respiratory infections:

acute sinusitis: 250 mg every 12 hours in 10 days. Medium to severe infections: 500 mg every 12 hours in 10 days.

Children:

Sore throat or tonsillitis: Children> 13 years: 500 mg x 1 time/day for 10 days.

Respiratory infections:

Sinusitis: Children> 13 years old: 250 mg every 12 hours in 10 days.

Average to serious to 5 hours every 12 hours in 10 days. Every 12 hours in 10 days.

Patients with liver failure:

No dose adjustments for patients with liver failure.

Patients with renal failure:

No dose adjustment for patients with creatinine clearance> 30 ml/min.

In patients with creatinine clearance

Elderly:

No need to adjust the dose in the elderly, except for serious liver and kidney function.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? The dose of 3000 mg/kg causes diarrhea and anorexia when used on monkeys but does not cause death.

Cefprozil is excreted mainly through the kidneys. In the case of serious overdose, especially in patients with impaired renal function, dialysis is used to eliminate the drug from the body.

If you have any overdose symptoms, stop taking the medication immediately and immediately notify your doctor.

What to do when forgetting a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using Cefprozil 250-US, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Digestive: diarrhea , nausea, vomiting, abdominal pain infection.

liver: jaundice of cholestasis. 1/1000

Liver: jaundice.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Cefprozil 250-UST is contraindicated in cases where people are sensitive to cefprozil or other ingredients of the drug, allergies to cephalosporin antibiotics.

Precautions when using

Colonitis and diarrhea related to Clostridium difficile/superinfection:

may appear and promote excessive development of non -sensitive strains or mushrooms if prolonged treatment. Precautions and appropriate treatment if superinfection occurs.

Hypersensitivity reactions:

Hypersensitivity reactions such as Anaphylaxis , Red Red Red Redes, Serum-like reactions, Stevens-Johnson syndrome have been reported.

Cross reaction:

There are cross -reactions between cephalosporins and other beta lactam antibiotics, including penicillin and cephamycin.

Therefore, before starting treatment with cefprozil, a thorough investigation of the patient's allergic history with cephalosporin, penicillin or other drugs.

The ability to drive and operate machinery

In a few cases of drugs that can cause dizziness, headache, hyperactivity, anxiety, insomnia, confusion, drowsiness, so it should be noted when driving and operating machinery.

Pregnancy

There is no full research project in pregnant women. Therefore, Cefprozil is only indicated in pregnant women when really necessary.

Breastfeeding period

cefprozil is distributed in milk, so use caution to breastfeed.

Drug interaction

cefprozil should not be used simultaneously with the following drugs:

Aminoglycosid antibiotics: Kidney toxicity.

Storage

Store drugs in a dry place, temperatures below 30 ° C, avoiding light.

Other drugs

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