Cefprozil 500-UST Treatment of infection (1 blister x 10 tablets)

Dosage form Box of 1 blister x 10 tablets
Specifications Cefprozil
Ingredient USP

Ingredient

Composition informationContent
Cefprozil500mg

Uses

Indications

Cefprozil 500 mg drug is indicated in the following cases:

Acute otitis medical treatment (Aom):

Aom treatment is caused by Streptococcus pneumoniae, Haemophilus influenzae (including seminarians - lactamase), or Moraxella Catatrhalis (including Beta -Lactamase)

When indicated against antibacterial, AAP organization recommends high doses of amoxicillin or amoxicillin combining clavulanate as an initial treatment option of AOM; Cephalosporin (Cefdinir, Cefpodoxim, Cefuroxim, Ceftriaxon) are recommended as an alternative to the initial treatment in patients with penicillin allergies without a history and/or have a serious penicillin allergy that has occurred in recent times.

Treatment of sore throat and tonsillitis:

Treatment of sore throat and tonsillitis caused by S. Pyogenes (beta-hemolytic streptococci group A). Overall Cefprozil is effective in eradicating S. Pyogenes in the nose and throat; Gift brand in preventing rheumatism.

AAP, IDSA, AHA organization proposes to use penicillin (10 days of drinking penicillin v or amoxicillin oral or single dose Penicillin G Benzathine using IM injection) is the treatment option for S.Pyogenes sore throat and tonsillitis; Other antibiotics (oral cephalosporin, oral macrolides, oral clindamycin) recommend as an alternative in the case of penicillin allergy patients.

Respiratory infections:

Treatment of acute sinusitis caused by S. Pneumoniae, H. Influenzae (including the Beta-lactamase seminarian), or M. CatVrhalis (including the Beta-lactamase seminarian). Due to the different resistance to S. Pneumoniae and H. Influenzae, IDSA organizations do not recommend cephalosporin for the second or third -generation oral oral route for bacterial sinusitis. Amoxicillin or amoxicillin combined with clavulanate is often used for more treatment. If an oral cephalosporin is used as an alternative for children (for example, in the case of penicillin allergies), a third -generation cephalosporin regimen (Cefixim or Cefpodoxim) and Clindamycin (or Linezolid).

The treatment of secondary infections of acute bronchitis caused by sensitivity S. Pneumoniae, H. Influenzae (including seminarians beta-lactamase), or M. Catrhalis (including Beta-lactamase seminarians).

Exacection treatment caused by bacteria of chronic bronchitis caused by sensitivity S. Pneumoniae, H. Influenzae (including Beta-lactamase seminarians), or M. Catrhalis (including beta-lactamase).

Skin infection and skin structure:

Treatment of skin infections and uncomplicated skin structures caused by staphylococcus aureus (including seminarians beta-lactamase) or S. Pyogenes.

Cefprozil has also been used to treat skin infections and uncomplicated skin structures caused by S. Epidermidis, S. Saprophyticu, S. Streptococci Group B or G, E. Coli, or K. Pneumoniae.

[Note: Cefprozil has no activity against staphylococci resistance methicillin]

Pharmacokic

on In Vitro, Cefprozil inhibits many gram-cheese and gram-tam bacteria strains by inhibiting the synthesis of bacterial cells. Under the hydrolysis of beta lactamase, Cefprozil is more stable than Cefaclor.

cefprozil has the following anti -bacterial effects:

Gram-aerobic grams: Staphylococcus aureus (including beta-lactamase production strains). Streptococcus Pneumonia, Streptococcus Pyogenes, Enterococcus Dansan, Enterococcus Faecalis, Listeria Monocytogenes, Staphylococcus Epidermidis, Staphylococcus SaproPhtics, Staphylococcus Wameri, Streptoccus Agalactia, Streptococci (Group C, D, F, and G).

Note: Cefprozil does not have the effect on Enterococcus Faecium to resist methicillin, and have all the acinetobacter strains. Entobacter, Morganella Morganii, Proteus Vulgaris, Providencia, Pseudomonas and Serratia. Methicillin resistant staphylococci is considered as Cefprozil resistance.

Gram-Aerobic: Haemophilus Influenza (including beta-lactamase production strains). Moraxella (Branhamella) Catnrhalis (including beta-lactamase production strains), CitrobacterDiversus, Escherichia Coli, Klebsiella Pneumonia. Neisseria Gonorrhoeae (including beta-lactamase production strains), Proteus Mirabilis. Salmonella spp., Shigella spp., Vibrio spp.

Anaerobic bacteria: Prevotella (Bacteroides) Melaninogenicus, Clostridium difficile, Clostridium perfringens. Fusobacterium spp., Peptostreptococcus spp., Propionibacterium acnes.

Note: Most strains of the Bactervides Fragilis group have been resistant to Cefprozil. Haemophilus influenza ampicillin resistant is considered as Cefprozil resistance.

pharmacokinetic

absorption:

After drinking, Cefprozil is quickly absorbed through the gastrointestinal tract. Birth in adults is about 90 - 95%, the concentration of the drug in plasma is about 1.5 hours. Food does not affect the absorption and peak concentration of the drug in plasma, but the time to reach the peak concentration in plasma can last 15-45 minutes.

Distribution:

The drug is distributed into tissues and fluid including gastric juice, middle ear fluid, tonsils and adenoidal tissues (VA). The drug is distributed to milk at low concentrations.

About 35 - 45% Cefprozil in the circulatory system linked to plasma proteins. The sale time of the drug in plasma is about 1 - 1.4 hours in adults with normal kidney function. Children 6 months to 12 years old, the sale time of the drug in plasma is about 0.94 - 2.1 hours.

Metabolism:

No information.

Era:

Cefprozil is excreted through the filtered urine in the glomerular filter and excreted in the renal tubules. About 54 - 70% of the doses of use are eliminated in urine in the form of unchanged within 24 hours.

Special subjects:

Elderly: Leaving clearance and increase AUC.

Semi -waste time of mild drugs in patients with impaired liver function (about 2 hours).

Semi -selling time of prolonged drugs (about 5.2 - 5.9 hours) in patients with impaired renal function.

Before taking Cefprozil 500-UST Treatment of infection (1 blister x 10 tablets)

How to use

Dosage and medication time for each specific case as prescribed by the treating doctor.

Take whole tablets with lots of water without meals.

Dosage

13 -year -old children:

Sore throat or tonsillitis: 500 mg x 1 time/day for 10 days.

Respiratory infections:

Acute sinusitis: 250 mg every 12 hours for 10 days. Average to serious to serious infections: 500 mg every 12 hours in 10 days.

Secondary infections of acute bronchitis: 500 mg every 12 hours for 10 days.

Infoliate skin and skin infections: 250 mg or 500 mg for 12 hours for 10 days.

Adults:

Acute otitis media: 500mg every 12 hours for 10 days.

Sore throat or tonsillitis: 500 mg x 1 time/day for 10 days.

Respiratory infections:

acute sinusitis: 250 mg every 12 hours in 10 days. Average to severe infection: 500 mg every 12 in 10 days.

Secondary infections of acute bronchitis: 500 mg every 12 hours, for 10 days.

Exacerbats of chronic bronchitis: 500 mg every 12 hours, for 10 days.

Infoliate skin and skin infections: 250 mg or 500 mg every 12 hours, for 10 days.

Patients with liver failure:

No dose adjustments for patients with liver failure.

Patients with renal failure:

No dose adjustment for patients with creatinine clearance> 30 ml/min.

In patients with creatinine clearance

Elderly:

No need to adjust the dose in the elderly, except for serious liver and kidney function.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

If you have any overdose symptoms, stop taking the medication immediately and immediately notify your doctor.

What to do when forgetting a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using Cefprozil 500 mg, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Digestive: diarrhea, nausea, vomiting, abdominal pain;

Liver: Increase AST (SGOT), ALT (SGPT);

Other: Vaginitis, genital itching.

Uncommon, 1/1000

Liver: Increase alkalin phosphatase and bilirubin;

Allergic reaction: Red, urticaria;

Central nerve: dizziness, headache, hyperactive, anxiety, insomnia, confusion, drowsiness.

Rare, ADR

Hematology: white blood cells.

Kidney: increased bun and blood creatinin.

Instructions on how to handle ADR

Notify the doctor with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Cefprozil 500 mg contraindicated drug in the following case:

Patients with cefprozil or other ingredients, allergies to cephalosporin antibiotics.

Precautions when using

Colon inflammation and diarrhea related to Clostridium difficile infection:

may appear and overdue of bacteria or fungi that are not sensitive when used for prolonged Cefprozil. Appropriate treatment should be taken when superinfection occurs.

Antibacterial treatments that change the normal microbiological system of the colon and may allow the excessive development of Clostridium difficile bacteria. C. Difficile infection (CD1) and diarrhea related to C. Difficile. Colitis (CDAD); Also known as diarrhea related to antibiotics and fake colitis or colitis reported almost with all antibacterial drugs, including Cefprozil, and may fluctuate in the severity of mild diarrhea to colitis that can be fatal. C. Difficile produces toxins A and B which contributes to the development of CDAD; C. Difficile produces hypertoxin associated with increasing the incidence of disease and deaths because they can be resistant and may have surgery to remove colon. Be careful to monitor CDAD if diarrhea develops during or after treatment with the drug. Caution for patients with a history of CDAD that has been reported for at least 2 months or longer after the anti -infection treatment.

If suspected or have diagnosed CDAD, stop using antibiotics without effect against C. difficile as soon as possible. Using appropriate supportive therapy (such as water and electrolytes, protein supplements), treatment with anti -infection drugs that are resistant to C. difficile (for example, Metronidazol vancomycin) and consider clinically indicated surgery.

Hypersensitivity reaction:

Hypersensitivity reactions (such as anaphylaxis, serum, erythema, Stevens-Johnson syndrome) have been reported when using the drug.

If the hypersensitivity reactions occur, stop cefprozil immediately and take appropriate treatment (such as using epinephrin, corticosteroids, maintain oxygen and adequate ventilation).

Cross reaction:

There is a cross reaction between cephalosporins and other beta-lactam antibiotics, including penicillin and cephamycins.

Before starting treatment, it is necessary to carefully understand the history of hypersensitivity reactions that happened earlier with cephalosporin, penicillin, or other drugs. Avoid using people who have a hypersensitivity reaction (anaphylaxis) and cautious in those who have had side effects (for example, rash, fever, EOSIN leukemia).

Caution:

Select and use antibacterial drugs:

To reduce the development of anti -drug bacteria and maintain the effectiveness of Cefprozil and other antibacterial, only used for treatment or prevention of infection that has been proven by the strains of bacteria sensitive to the drug.

History of gastrointestinal diseases:

cephalosporin should be used carefully in patients with a history of gastrointestinal disease, especially colitis.

Exoder castor in the film formula can cause abdominal pain and diarrhea when used orally.

Can give Test COAMB’s directly positive.

The risk of drug resistance may occur if used in case of non -bacterial or prolonged use.

For people with kidney failure, developing non -sensitive pathogens.

The ability to drive and operate machinery

In a few cases of drugs that can cause dizziness, headache, hyperactive, anxiety, insomnia, confusion, drowsiness. Therefore, it should be noted when driving and operating machinery.

Pregnancy

There is no full research project in pregnant women. Therefore, Cefprozil is only indicated in pregnant women when really necessary.

Breastfeeding period

cefprozil is distributed in milk, so use caution to breastfeed.

Drug interaction

cefprozil should not be used simultaneously with the following drugs:

Aminoglycosid antibiotics: Kidney toxicity.

Alkaline glucose: may appear fake positive when checking urine glucose.

Probenecid: Increasing AUC (area under the curve) Cefprozil.

Storage

Store the drug in a dry place, temperatures below 30 ° C, avoiding light.

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