Cefurich 500mg USP medicine for infection treatment (2 blisters x 5 tablets)

Dosage form Box of 2 blisters x 5 tablets
Specifications Cefuroxim
Ingredient USP

Ingredient

Composition information	Content
Cefuroxim	500mg

Uses

Indications

cefurich 500 are indicated in the following cases:

Treatment of lower respiratory infections such as pneumonia, acute and chronic bronchitis.

Treatment of gonorrhea, uncomplicated urethritis caused by gonorrhea and cervicitis. Oral medications are acetyl esters. Cefuroxim acetyl is precursor, itself has no antibacterial effect, into the body hydrolyzed under the effect of the enzyme esterase into cefuroxim to work.

Cefuroxim has antibacterial activity due to synthetic inhibition of bacterial cell walls by attaching proteins attached to penicillin (PBP), which are proteins involved in the composition of bacterial cell membranes. As a result, the synthetic cell wall will weaken and not durable under the impact of osmotic pressure. The affinity of Cefuroxim with PBP of different types will determine the effect of the drug.

Pharmacokinetics

absorption

After taking the medication, Cefuroxim acetyl is absorbed through the digestive tract and is quickly hydrolyzed in the intestinal mucosa and in the blood to release Cefuroxim into the circulatory system. The best absorbed drug when taken at meals.

Distribution

The level of cohesion with protein is shown from 33 - 50% depending on the method used.

Elimination

Cefuroxim is not metabolized and eliminated by the filtration process in the glomerular and the renal tubules.

Before taking Cefurich 500mg USP medicine for infection treatment (2 blisters x 5 tablets)

How to use

The drug is used by oral. Dissolve effervescent tablets in a glass of water.

Dosage

adults

Most cases of infections respond to a dose of 250mg x 2 times/day.

For cases of severe pneumonia and bronchial:

500mg x 2 times/day.

For urinary tract infections:

125mg or 250mg, 2 times a day.

Treatment of cervical gonorrhea or uncomplicated urethra or uncomplicated rectal gonorrhea in women:

Take a single dose 1g.

In the new Lyme disease:

Take 500mg, 2 times a day, for 20 days.

Children

Children from 3 months to 2 years:

10mg/kg (maximum 125mg), 2 times a day.

Children from 2 to 12 years old:

15mg/kg (maximum 250mg), 2 times a day.

Patients with liver failure

No dose adjustment in liver failure patients.

Patients with renal failure

In the case of creatinine clearance

What to do when overdose?

Symptoms

Most drugs only cause nausea, vomiting and diarrhea. However, it may cause an increase in nervous stimulation and seizures, especially in people with kidney failure.

How to handle

Need to care about the overdose of many drugs, abnormal drug interaction and pharmacokinetics in patients.

Protects the respiratory tract of the patient, supports ventilation and infusion. If the seizure is developed, stop using the drug immediately, anti -convulsions may be used if clinically indicated. Hemorrhage can eliminate blood from the blood but most of the treatment is support or solve symptoms.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using Cefurich 500 mg, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Systemic body: Anaphylaxis reaction, Candida fungal infection.

Stop using Cefuroxim. In case of allergies or serious hypersensitivity reactions, supportive treatment (maintenance of ventilation and use of adrenalin, oxygen, corticosteroid intravenous).

When a mild mild fake colitis, usually just stop the drug. In medium and severe cases, infusion and electrolytes, protein supplements and metronidazol treatment (an antibacterial antibacterial effect against colitis caused by Clostridium difficile). It is necessary to be careful to check the history of allergies in the case of suspected fake colitis due to the disease that may appear late after 2 months, even later after stopping antibiotic treatment regimen.

Notify the doctor with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Cefurich 500 mg is contraindicated in the following cases:

Hypersensitivity to cefuroxim or any ingredients of the drug.

Be cautious when using

Before starting treatment with cefuroxim, a thorough investigation of the patient's allergic history with cephalosporin, penicillin or other drugs. Because there is a cross -sectional reaction (including anaphylactic shock reaction) between people who are allergic to beta -lactam antibiotics, it is necessary to be careful to treat anaphylaxis when using cefuroxim for patients who have previously allergic to penicillin.

Kidney test when treated with cefuroxim, especially in serious illnesses, is taking the maximum dose. Should be cautious when giving patients simultaneously with strong diuretic drugs, because it can have adverse effects on kidney function. Using long -term cefuroxim can develop drug -resistant bacteria, change glucose quantitative test.

Need to monitor patients carefully. If serious superinfection during treatment, medication must be stopped.

Should be very careful when prescribing broad -spectrum antibiotics for people with gastrointestinal diseases, especially colitis.

Increased kidney toxicity when using simultaneous antibiotics aminoglycosides and cephalosporin.

Products containing excipients with castor should pay attention to side effects such as nausea, vomiting, abdominal pain and diarrhea.

The ability to drive and operate machinery

In a few cases, the drug can cause headaches and dizziness. Therefore, it should be noted when driving and operating machinery.

Pregnancy

only taking drugs in pregnant women if really necessary.

The period of breastfeeding

The drug is excreted in breast milk, so be careful when prescribed for breastfeeding women.

Drug interaction

ranitidin and sodium bicarbonate reduces the bioavailability of cefuroxim acetyl. Cefuroxim acetyl should be used at least 2 hours after antacids or h2 blockers.

High doses Probenecid reduces Cefuroxim clearance in the kidney, making Cefuroxim concentration in the blood higher and longer. Used with aminoglycosides increases the likelihood of kidney poisoning.

The drug can cause fake positive reactions when testing glucose with oxidation but does not affect the enzyme reaction.

Reducing the effects of female sex hormones: Cefuroxim acetyl orally can affect the bacterial system in the intestine, reducing estrogen reabsorption, thus reducing the effect of oral contraceptives containing estrogen and progesterone.

Collaborate with anticoagulants to increase Inr.

Storage

Store in closed packaging, dry place, avoid light and humidity, temperature below 30ºC.

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