Cefurobiotic medicine 500mg Tenamyd treatment of infection (5 blisters x 10 tablets)

Dosage form Box of 5 blisters x 10 tablets
Specifications Cefuroxime
Ingredient Tenamyd

Ingredient

Composition information	Content
Cefuroxime	500mg

Uses

indications

Cefurobiotic 500mg drug is indicated in the following cases:

Oral Cefurobiotic 500 is used to treat sensitive bacteria infections, including:

mild infections to fit the lower respiratory tract (pneumonia, acute bronchitis), otitis media and recurrent sinusitis, tonsillitis and recurrent sore throat caused by sensitive bacteria. Female. Cefuroxim acetyl after being absorbed into the body will be hydrolyzed into cefuroxim with antibacterial activity. Cefuroxim has antibacterial activity due to synthetic inhibition of bacterial cell walls by attaching essential target proteins (penicillin -mounted proteins). The cause of drug resistance may be caused by bacteria that produce cephalosporinase enzymes, or due to changes in penicillin -mounted proteins.

Cefuroxim has a good and anaerobic gram -negative and anaerobic activity, including most staphylococcus strains of penicilinase, and gram -negative antibacterial activity. Cefuroxim has a high activity, so there is a low minimum inhibitory concentration for streptococcus strains (group A, B, C and G), gonococcus and meningoccus strains. En The strains of Clostridium Difficile, Pseudomonas spp., Campylobacter spp., Acinetobacter Calcoaceticus, Legionella spp. All are not sensitive to Cefuroxim.

Staphylococcus aureus strains, Staphylococcus Epidermidis resistant methicilin are resistant to cefuroxim. Listeria monocytogenes and most of the Enterococcus strains are also resistant to cefuroxim.

Dynamic pharmacokinetics

After drinking, Cefuroxim acetyil is absorbed through the gastrointestinal tract and is quickly hydrolyzed in the intestinal and blood mucosa to release Cefuroxim into the circulatory system. The drug is best absorbed when taken at meals. The peak concentration of cefuroxim in plasma varies depending on the form of tablets or chaos. The drug reaches a maximum concentration of 12-16 mg/liter at about 3 hours after taking 500mg of Cefuroxim.

Cefuroxim is widely distributed throughout the body, including pleural fluid, phlegm, bone, fluid and aquatic fluid. The apparent distribution volume in healthy adults ranges from 9.3-15.8 liters/1.73m2. Cefuroxim passes through the bloody barrier when the meninges are inflamed. The drug through the placenta and excreted through breast milk.

Cefuroxim is not metabolized and eliminated in the form of non -variable, about 50% of the glomerular filtration and about 50% through excretion in the renal tubules. The drug is high in urine. Probenecid inhibits cefuroxim excretion through the renal tubules, causing the cefuroxim concentration in plasma to rise and last longer. Cefuroxim only excreted in bile in very small amounts. Cefuroxim concentration in serum is reduced when separating.

Before taking Cefurobiotic medicine 500mg Tenamyd treatment of infection (5 blisters x 10 tablets)

How to use

Oral content. Cefuroxim acetyl is an acetoxymethyl ester used by oral in the form of tablets or chaos.

Dosage

Adults:

Sore throat, A-Mi-al-inflammatory or jaw sinusitis caused by sensitive bacteria: Take 250 mg, 12 hours.

In the acute drama of chronic bronchitis or acute bronchitis infections or in skin infections and soft tissue: oral 250 mg or 500 mg, every 12 hours.

In uncomplicated urinary tract infections: taking 125 mg or 250 mg, 12 hours.

Cervical gonorrhea or uncomplicated urethra or uncomplicated rectal gonorrhea in women: Take the only 1 g dose, should take the same 1g Probenecid.

Children over 2 years old:

Sore throat, A-Mi-dan inflammation: Take the mixture of 20 mg/kg/day (maximum 500 mg/day) divided into 2 small doses; Or take 1 tablet 125 mg every 12 hours.

Middle otitis, impetigo: The form of epidemic is 30 mg/kg/day (maximum 1 g/day) divided into 2 small doses; The tablet form is 250 mg, 12 hours. Do not crush cefuroxim acetyl

Note:

Not to be careful in patients with renal impairment or being separated from the kidneys or the elderly when drinking without an overdose of maximum normal 1 g/day.

The normal treatment is 7 days

This drug is only used as prescribed by a doctor. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? However, it can cause an increase in nervous stimulation and seizures, especially in people with kidney failure.

Management: Protects the respiratory tract of the patient, supports ventilation and infusion. If convulsions are detected, stop using the drug immediately, anti -convulsions may be used if clinically indicated. L

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Cefurobiotic 500, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Digestive: diarrhea

Body: Anaphylaxis reaction, candidiasis infection.

Blood: Eosin hypernagus, leukopenia, neutropenia, positive Coombs test.

Digestive: Nausea, vomiting.

Body: Fever.

digestive: fake colitis.

Skin: polymorphic erythematosus, Stevens - Johnson syndrome, poisoned epidermal necrosis.

central nervous system: convulsions (if high doses and kidney failure), headache, agitation.

Other parts: joint pain.

Instructions on how to handle ADR

Notify the doctor with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Cefurobiotic 500 drug is contraindicated in the following cases:

Patients with a history of allergy to antibiotics of cephalosporin.

Be cautious when using

Before starting treatment with cefuroxim, a thorough investigation of the patient's allergic history with cephalosporin, penicillin or other drugs.

Because there is a cross -sectional reaction (including anaphylactic shock reaction), between people who are allergic to beta -lactam antibiotics, should be careful, and are ready for anaphylactic shock treatment when using Cefuroxim for patients who have previously been allergic to penicillin. However, with Cefuroxim, the hypersensitivity reaction to the penicillin has a low rate.

Although Cefuroxim rarely causes renal function change, it is still recommended to check the kidneys when treated with cefuroxim, especially in serious illnesses who are taking the maximum doses. Should be cautious when giving patients simultaneously with strong diuretic drugs, because it can have adverse effects on kidney function.

Long -term Cefuroxim can make unnecessary strains overexplicable. Need to follow the patient carefully. If serious superinfection during treatment, medication must be stopped.

There has been a fake colitis report that occurs when using broad -spectrum antibiotics, so it is necessary to consider this disease and treat Metronidazol for patients with severe diarrhea due to antibiotics. Should be very careful when prescribing broad -spectrum antibiotics for people with gastrointestinal diseases, especially colitis.

Records that kidney toxicity has simultaneously used aminoglycosid and cephalosporin antibiotics.

The ability to drive and operate machinery

should be cautious when experiencing side effects such as headache, agitation or other reactions that affect the ability to operate train machinery.

Pregnancy

studies on rats and rats do not see signs of fertility or fetus damage due to cefuroxim drugs

Use this antibiotic to treat nephritis - pyelonephritis in pregnant people does not see unwanted effects in newborn babies after exposure to drugs in the tamarind uterus. Cephalosporin is often considered safe to use during pregnancy.

However, the strict research on pregnant women is incomplete. Because studies on animals are not always predictable to be responded by people, they only use this drug on pregnant people if needed.

Breastfeeding period

cefuroxim excreted in breast milk at low concentrations. It seems that this concentration does not have an impact on breastfed babies, but should be concerned when children have diarrhea, so and rash.

Drug interaction

Reduce effect: Ranitidine with sodium carbonate reduces the bioavailability of cefuroxim acetyl. Cefuroxim acetyl should be used at least 2 hours after antacids or H2 blockers, as these drugs can increase the stomach pH

Increased effect: High doses Probenecid reduces Cefuroxim clearance in the kidneys, making Cefuroxim concentration in plasma higher and longer. Increasing toxicity: Aminoglycosides increase the likelihood of kidney poisoning.

Storage

In a dry place, temperatures below 30 ° C, avoid light.

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