Celecoxib 100 - HV USP analgesic, antipyretic, anti -inflammatory (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Celecoxib
Ingredient Dysmenorrhea, colon polyps, rectal polyps, arthritis, rheumatoid arthritis, osteoarthritis, inflammation, toothache

Ingredient

Composition information	Content
Celecoxib	100mg

Uses

indications

Celecoxib 100 - HV is indicated in the following cases:

Treatment of rheumatoid arthritis and osteoarthritis diseases in adults. Celecoxib is a new generation NSAID (NSAID) analgesic (NSAID).

In the body there exist two types of cyclooxygersae (COX): COX -1 and COX-2, Cox-1 catalysts that create beneficial substances for the stomach and kidney mucosa. COX-2 is found in inflammatory tissues.

Celecoxib inhibits prostaglandin synthesis due to selective inhibition on COX-2, so it reduces many harmful effects on the stomach, kidneys and does not interfere with blood clotting.

Dynamic pharmacokinetics

absorption

Celecoxib's peak concentration reached about 3 hours after 1 oral dose. Food does not affect the absorption of the drug.

distribution

Celecoxib is mainly eliminated by intermediate metabolism of Cytochrom P450 2C9.

Elimination

Celecoxib is excreted mainly by liver metabolism, about 57 % of the dosage excreted through feces, and 27 % excreted through urine.

Before taking Celecoxib 100 - HV USP analgesic, antipyretic, anti -inflammatory (10 blisters x 10 tablets)

How to use

drink while eating or after meals.

Dosage

osteoarthritis: 1 tablet x 2 times/ day or 2 capsules 2 times/ day.

rheumatoid arthritis: 1-2 capsules x 2 times/ day.

In the gland gland polyp: 4 capsules 2 times/ day.

In case of mild-medium liver failure: half a dose.

Do not use for patients with liver failure, severe kidney failure.

Use as directed by the doctor.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? Rarely occur hypertension, acute renal failure, respiratory failure.

Handling: indicating symptomatic treatment and supportive treatment when overdose. If the symptoms of overdose are appearing within 4 hours after drinking, it may be prescribed for vomiting, active carbon, or osmosis.

What to do when forgetting 1 dose?

Not recorded.

Side Effects

When using Celecoxib 100 - HV, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Digestive system: abdominal pain, indigestion, diarrhea, nausea, flatulence, stomach ulcers.

Nervous system: headache, insomnia, shock, fainting.

kidney failure, heart failure, severe progression of high blood pressure, chest pain, tinnitus, sensitive to light, weight gain, water retention, cardiovascular thrombosis. allergies.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Celecoxib 100 - HV contraindicated in the following cases:

Too hypersensitivity to Celecoxib.

History of allergies with sulfonamids, patients with asthma, urticaria or allergies when taking aspirin or other NSAIDs.

Peptic - duodenum ulcer.

Heart failure heavy.

Caution when using

Precautions when taking drugs in people with a history of ulcer, gastrointestinal bleeding.

Old, exhausted, pregnant and lactating women.

Hepatic failure, severe renal failure, edema, Hypertension , heart failure.

This long -term medication may increase cardiovascular risk, including heart attack, blood clotting, chest pain, cardiac arrest and stroke. Gastrointestinal complications: ulcers, hemorrhage, perforation.

The risk of cardiovascular thrombosis when taking NSAID drugs includes: myocardial infarction, stroke, which can lead to death. This risk appears early in the first few weeks of medication and increases over time of drug use, mainly at high doses.

To minimize the risk of adverse events, Celecoxib is required at the lowest doses in the shortest time.

The ability to drive and operate machinery

Caution with the driver and operating machinery due to drugs can cause dizziness.

During pregnancy

There is no complete research, only drugs should be used when the use is greater than the risk of the fetus. Do not use Celecoxid for the last 3 months of pregnancy.

Breastfeeding period

whether Celecoxib is not distributed into breast milk, need to consider benefits and risks or stop breastfeeding or stop taking medication.

Drug interaction

Celecoxib inhibits Cytochrom P450 2D6 thus interacting with metabolic drugs through Cytochrom P450 2D6.

Celecoxib reduces the effect of antihypertensive drugs inhibiting Angiotensin II.

Celecoxib reduces the effect of increasing the excretion of sodium sodium of Furosemid and Thiazid in some patients.

Celecoxid increases digestive ulcers and other complications when used with other aspirin and other NSAIDs.

fluconazole increases the level of melecoxib in plasma.

Lithi: Reduce lithium elimination when sharing Celecoxib.

Storage

In a dry place, avoid light, temperatures below 30 ºC.

Other drugs

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