Celecoxib 100mg Vidipha treatment of osteoarthritis, rheumatoid arthritis (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Celecoxib
Ingredient Dysmenorrhea, joint spondylitis, arthritis, rheumatoid arthritis, teen arthritis

Ingredient

Composition information	Content
Celecoxib	100mg

Uses

Indications

Celecoxib 100mg is indicated to reduce the signs and symptoms of osteoarthritis and rheumatoid arthritis in adults.

Pharmacokological

Celecoxib is a nonsteroidal anti -inflammatory drug, which has anti -inflammatory and analgesic effects. The mechanism of action of Celecoxib is due to the inhibition of prostaglandin synthesis, mainly through the inhibition effect of isenzyme cyclooxygenase - 2 (COX - 2) leading to a reduction in the formation of prostaglandin. At the treatment concentration, Celecoxib does not inhibit cyclooxygenase enzyme - 1 (COX - 1).

pharmacokinetic

The drug is quickly absorbed through the digestive tract to reach the peak concentration (705 ng/mL) after 3 hours. Increased drugs when taken at a meal are high in fat, used with drugs, foods containing tannin, aluminum Magnesi will reduce the concentration of Celecoxib in plasma.

Celecoxib is much distributed to the tissues in the body. At plasma treatment concentration, 97% Celecoxib is attached to plasma proteins.

Metabolic drugs through the liver into metabolites are not active by isoenzyme CYP450 2C9.

Elimination: Half lifetime elimination in plasma of Celecoxib after drinking is 11 hours, and the clearance coefficient in plasma is about 500 ml/ min. The half -life of the drug lasts for people with renal failure or liver failure. Celecoxib eliminates about 27% in urine and 57% in feces, less than 3% of the doses are eliminated unchanged.

Before taking Celecoxib 100mg Vidipha treatment of osteoarthritis, rheumatoid arthritis (3 blisters x 10 tablets)

How to use

Celecoxib 100 mg oral.

Dosage

Dosage for treatment in the following cases:

osteoarthritis: Use 100 mg/time x 2 times/day.

rheumatoid arthritis: Take 100 - 200 mg/time, 2 times a day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Overdose

There has been no clinical overdose. Dosage of 1,200 mg or 1,200 mg/time, 2 times/day, continuous use for 9 days also do not see significant signs of overdose.

How to handle

If the overdose is seen. Take the patient immediately to the nearest medical facility.

There is no specific treatment but only symptoms combined with patient physical improvement measures.

What to do when forgetting a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using Celecoxib 100 mg, you may experience unwanted effects (ADR).

The unwanted effect of Celecoxib at the usual doses is generally light and related to the digestive tract.

Common: abdominal pain, diarrhea, indigestion, flatulence, nausea; Sore throat, rhinitis, sinusitis; Upper respiratory tract infection; insomnia, dizziness, headache; Da Da; Back pain, peripheral edema.

Rare: infection, sudden death, anaphylactic reaction, angioedema; fainting, stroke, peripheral mail; intestinal obstruction, intestinal perforation, gastrointestinal bleeding ...; gallstones, hepatitis, jaundice, liver failure; reducing platelets, leukopenia; paranoia; renal failure; Skin erythema, peeling dermatitis, Stevens syndrome - Jonhson.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Celecoxib 100 mg is contraindicated in the following cases:

Patients with a history of hypersensitivity to Celecoxib.

Patients with allergies to sulfonamids, urticaria patients, or allergies to aspirin or other NSAID group analgesic drugs.

Patients with peptic ulcer, liver failure, kidney failure, asthma, edema, intestinal inflammation, heart failure from medium to severe.

Pregnant women, breastfeeding.

Do not coordinate with Celecoxib with other nonsteroidal anti -inflammatory drugs (including with high doses of Aspirin than 500 mg/ day), corticosteroids, warfarin (increasing the risk of bleeding complications ...).

should not be used after coronary heart surgery as it can increase the danger of harmful effects such as myocardial infarction and stroke.

Caution when using

Celecoxib drugs only used in special cases, when using traditional painkillers ineffective.

No treatment continues when the symptoms are out of symptoms.

It is necessary to assess cardiovascular risk before prescribing and in the drug, especially focusing on patients who have had cardiovascular disease (myocardial infarction, stroke).

Do not stop coordinating with low -dose aspirin to prevent cardiovascular disease.

Caution for people with heart disease, hypertension, diabetes, risk of renal impairment, elderly, weakness, users of diuretics or taking angiotensin enzyme inhibitors.

Caution for patients with a history of heart disease, peripheral artery or brain disease.

The ability to drive and operate machinery

There is no document about this issue.

Pregnancy

Avoid for pregnant women at the end of pregnancy.

Breastfeeding period

Not yet confirmed whether the drug has passed through the fence of breast milk or not, so it is only used when it is really necessary and must stop breastfeeding.

Medicinal interaction

metabolism of Celecoxib via cytochrom P450 2C9 intermediaries in the liver. Celecoxib simultaneous use with drugs that inhibit this enzyme can affect the pharmacokinetics of Celecoxib, so be cautious when used simultaneously with these drugs. In addition, Celecoxib also inhibits Cytochrom P450 2D6. Therefore, the interaction between Celecoxib and drugs is metabolized by P450 2D6.

Use Celecoxib simultaneously with angiotensin transferring enzyme inhibitors: may reduce the anti -hypertension effect of enzyme inhibitors Angiotensin transfer.

Celecoxib may reduce the effect of increasing the excretion of sodium sodium of Furosemid and Thiazid in some patients.

Simultaneous use of Celecoxib with aspirin can lead to an increase in gastrointestinal ulcer ratio or other complications.

Simultaneous use of celecoxib with fluconazole can lead to significantly increasing plasma concentrations of Celecoxib. Celecoxib should be started with the lowest recommended doses in patients with Fluconazole simultaneously.

Celecoxib may reduce the lithe's kidney clearance, leading to an increase in lithium concentration in plasma.

When using Celecoxib simultaneously with warfarin: there may be complications of bleeding in combination with increased prothrombin time in some patients (mainly elderly people).

Storage

Leave in a dry place, the temperature does not exceed 30 ° C, avoiding light.

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