Celecoxib 200mg Domesco Treatment of osteoarthritis, rheumatoid arthritis (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Celecoxib
Ingredient Domesco

Ingredient

Composition information	Content
Celecoxib	200mg

Uses

indications

Celecoxib drugs are indicated in the following cases:

Treatment of symptoms of osteoarthritis and rheumatoid arthritis in adults. Non -steroid anti -inflammatory drugs, selective inhibition of cyclooxygenase -2 (COX - 2), have anti -inflammatory, analgesic, fever -reducing effects. The mechanism of action of Celecoxib is to inhibit the synthesis of prostaglandin, mainly through inhibition of isenzyme cyclooxygenase - 2 (COX - 2), reducing the formation of premature prostaglandin. Celecoxib inhibits selective on COX - 2 so side effects on the gastrointestinal tract are less than non -selective nonsteroidal anti -inflammatory drugs.

Dynamic pharmacology

Celecoxib quickly absorbed through the digestive tract. The peak concentration of plasma is at 3 hours after taking a single dose of 200 mg at hunger, the average is 705 ng/ml. The drug concentration in a stable state in plasma is achieved within 5 days; There is no accumulation. In the elderly over 65 years old, the peak concentration in plasma and AUC increased by 40 and 50% compared to young people, the AUC of Celecoxib in a stable state increased by 40 or 180% in mild or medium liver failure, decreased by 40% in people with chronic kidney failure compared to normal people.

The drug is heavily distributed to the tissue, the integral distribution in a stable state is about 400 liters (about 7.14 liters/ kg) at the treatment concentration, 97% of Celecoxib is attached to plasma proteins.

Metabolic mainly through the liver into non -active metabolites by isenzyme CYP450 2C9.

Semi -selling time in plasma after drinking is 11 hours, the clearance coefficient is about 500 ml/min. The sale time of the drug is prolonged in people with kidney failure or liver failure. Celecoxib eliminates about 27% in urine and 57% in feces, less than 3% of the doses are eliminated unchanged.

Before taking Celecoxib 200mg Domesco Treatment of osteoarthritis, rheumatoid arthritis (3 blisters x 10 tablets)

How to use

oral medication. Should drink at meals for better absorption.

Dosage

Bone degeneration - joints

200 mg/day, 1 time or divided into 2 times.

100 - 200 mg/time, 2 times a day.

400 mg/time, 2 times a day.

The usual dose in adults: 400 mg/time/day, followed by 200 mg if necessary, on the first day. To continue analgesic, can give 200 mg, 2 times a day.

Elderly (over 65 years old)

No dose adjustment. For the elderly with a body weight of less than 50 kg, taking the lowest recommended dose at the beginning of treatment. Mild liver failure, average reduced dose.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? These manifestations are often recovered with supportive treatment. The gastrointestinal bleeding also occurs. The more rare manifestations are hypertension, acute renal failure, respiratory inhibition and coma. Anaphylactic reactions have been notified to the treatment dose of nonsteroidal anti -inflammatory drugs and may occur during an overdose.

Treatment: Symptoms and support, no specific antidote to nonsteroidal anti -inflammatory drugs. In the first 4 hours after overdose, vomiting or active carbon (60 - 100 g for adults, 1-2 g/ kg for children), or an osmotic bleach may be useful for patients who have signed a pathology or have taken a large amount of drugs.

It is not known whether Celecoxib can be equal to blood separator or not, but the drug is attached to protein at a high rate of suggesting the use of forced urinary tract measures, urine alkalization, hemorrhage, or blood transfusion may not be effective to eliminate large amounts of Celecoxib from the body.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using Celecoxib, you may experience unwanted effects (ADR).

Common

Abdominal pain, diarrhea, indigestion, flatulence, nausea, sore throat, rhinitis, sinusitis, upper respiratory tract infections, insomnia, dizziness, headache, skin rash, back pain, peripheral edema.

rarely

Fainting, congestive heart failure, ventricular vibration, pulmonary embolism, stroke, peripheral mail, thrombosis, inflammation, bowel obstruction, intestinal perforation, gastrointestinal bleeding, bleeding colitis, esophagus, pancreatitis, bowel obstruction, face stones, hepatitis, jaundice, liver failure, reduced amount of platelet, non -regenerated blood cellular anemia, reduction Murder, acute renal failure, interstitial nephritis, diverse erythema, peeling dermatitis, Stevens - Johnson syndrome, bacterial infection, sudden death, anaphylactic reaction, angioedema.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Celecoxib drugs contraindicated in the following cases:

Hypersensitivity to the ingredients of the drug (excipients: lactose, Povidon, Croscarmes Sodium, Sodium Lauryl Sulfate, Magnesi Stearate), sulfonamid.

heart failure, severe renal failure (Creatinine clearance ratio

Inflammation (Crohn's disease, ulcerative colitis).

History of asthma, urticaria or allergic reactions with aspirin and other nonsteroidal anti -inflammatory drugs.

Be cautious when used

Patients with a history of gastrointestinal ulcers, asthma, allergies when taking aspirin or an non -sreroid anti -inflammatory drug because there may be anaphylactic shock.

Elderly, weakened because it is easy to cause gastrointestinal bleeding and renal function.

Poisoning the kidneys, especially when maintaining the blood flow through the kidneys, the renal prostaglandin requires support. People with high risk include people with heart failure, kidney failure or liver failure.

People with edema, water retention because the drug causes fluid to worse the disease.

People with foreign cell loss (due to strong diuretics).

Celecoxib has no platelet resistance and does not protect the complications due to myocardial ischemia, especially the high doses of prolonged high doses (400 - 800 mg/day).

The ability to drive and operate machinery

Celecoxib can cause tinnitus, dizziness, so be careful when driving a train, vehicle and operating machinery.

Pregnancy

should only use Celecoxib for pregnant women when the benefits are higher than the risk that may occur for fetuses. Do not use Celecoxib in the last 3 months of pregnancy, as Prostaglandin synthesis inhibitors may have a bad effect on the cardiovascular system of the fetus.

Breastfeeding period

whether Celecoxib is unknown whether it is distributed into breast milk or not, so only use the drug when really necessary and must stop breastfeeding if taking the drug.

Interactive drug

Angiotensin enzyme inhibitors: reduce the anti -hypertension effect of enzyme inhibitors Angiotensin.

Diuretics: Reducing the effect of increasing the excretion of sodium sodium of Furosemid and Thiazid in some patients, due to the inhibition of prostaglandin synthesis and the risk of renal failure may increase.

Aspirin: Increasing the rate of gastrointestinal ulcers and other complications.

fluconazole: significantly increasing plasma concentrations of Celecoxib, so the lowest dose recommends in patients are using fluconazol.

Lithi: Reducing lithium kidney clearance, this leads to increased lithium concentration in plasma.

warfarin: Bleeding complications in combination with increased prothrombin time occurred in some patients.

Storage

in a dry place, at 15 - 30 ° C, avoid light.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.