Celextavin Vidipha medicine for acute and chronic allergies (100 tablets)

Dosage form Box of 100 capsules
Specifications Betamethasone, dexchlorpheniramin maleat
Ingredient Allergic rhinitis, urticaria, upper respiratory tract

Ingredient

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Composition informationContent
Betamethasone0.25mg
Dexchlorpheniramin maleat2mg

Uses

Indications

Celextavin drug is indicated in the following cases:

Treatment of acute and chronic allergy symptoms, especially in respiratory, skin and eye symptoms.

Pharmacokology

betamethason

betamethason is a synthetic corticosteroid, which has a very strong glucocorticoid effect (anti -inflammatory, anti -allergic and immunosuppressive inhibition), with mineralocorticoid effects (risk of Na+ and edema) negligible. Due to the little effect of mineralocorticoid, Betamethasone is very suitable in cases where the pathology that holds the country is disadvantage.

dexclorpheniramin maleat

Oral antihistamine, propylamine structure, has the following characteristics:

  • The sedative effect in the usual dose due to antihistamine and adrenalin inhibitors in the central nervous system.
  • anti -cholinergic effect (inhibiting competition with acetylcholin in the muscarin receptors of organs subject to the control of the sympathetic system (the fiber of the cholinergic nodes) and the inhibition of the effect of acetylcholine in plain muscle) is the source of extraordinary effect on the peripheral.
  • Inhibiting the peripheral adrenalin may affect the dynamics of the machine (which can cause posture blood pressure).

    • Antihistamine drugs have the common characteristics of antagonism, due to the opposite of the mutual painting more or less inversely, with the effect of histamine, mainly on the skin, blood vessels and charm in the conjunctiva, nose, bronchial and intestines.

    The antihistamine itself has a mild anti -them, but when used in combination, it will increase the effects of morphine cough drugs as well as other bronchodilators such as sympathetic amines.

    pharmacokinetic

    betamethason

  • Betamethasone is easily absorbed through the gastrointestinal tract.
  • betamethason quickly distributed into all tissues in the body. The drug through the placenta and can be exported to breast milk in small amounts. During the circulation, Betamethason is mainly linked to globulin, with little albumin.
  • Betamethason ratio is linked to blood protein about 60%, lower than hydrocortisone.
  • betamethason is a long -lasting glucocorticoid, with half a lifetime about 36 - 54 hours. The drug is metabolized mainly in the liver and excreted the kidneys mainly with the metabolic rate of less than 5%. Because Betamethason has a slow metabolic speed, a low protein and a long -life protein, the effect is stronger and the effect lasts longer than natural corticosteroids.
  • Dexclorpheniramin has a bioavailability of about 25-50% due to significant metabolized when the first time. The drug reaches the maximum concentration in the blood after 2-6 hours. The maximum effect is achieved after taking 6 hours. The impact time is 4 - 8 hours.
  • The ratio of cohesion to plasma protein is 72%. The drug is metabolized mainly in the liver and produces methyl -original metabolites, which is not active. The drug is mainly eliminated through the kidneys and depending on the urine pH, 34% dexclorpheniramine is excreted in a constant form and 22% in the form of methyl -original metabolites.
  • Semi -cancellation time from 14 - 25 hours.

    • Pharmacokinetics in special cases

  • Hepatic failure or kidney failure increases the half -life of dexclorpheniramin.
  • dexclorpheniramin through placenta and breast milk.

    • Before taking Celextavin Vidipha medicine for acute and chronic allergies (100 tablets)

    How to use

    Should take the medicine in the morning (6 hours - 8 hours) so as not to affect the episode of the adrenal gland.

    Dosage

    Adults and children over 30 months old: 1 - 4 capsules/24 hours.

    Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

    What to do when overdose?

    betamethason

  • Symptoms: Systemic effects due to corticosteroid overdose include: Sodium and water holding effects, increased appetite, mobilizing calcium and phosphorus accompanied by osteoporosis, loss of nitrogen, hyperglycemia, reducing tissue regeneration effect, increasing sensions to infections, adrenal impairment, increased renal shell activity, mental disorders and nerves. Monitor the serum and urine electrolyte. Pay special attention to sodium and potassium balance. In the case of chronic poisoning, stop the drug slowly. Treatment of electrolyte imbalance if necessary.
  • Symptoms: convulsions (especially in children and children); cognitive disorders, coma. However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

    • Side Effects

    When using Celextavin, you may experience unwanted effects (ADR).

    Common, ADR> 1/100

  • Metabolism: loss of potassium, sodium hold, water retention.
  • Hormonal: Menstrual irregular menstruation, Cushing syndrome development, inhibiting fetal growth in the uterus and children, reducing glucose tolerance, revealing potential diabetes, increasing insulin demand or hypoglycemic drugs in diabetic people.

    • Muscle muscle: muscle weakness, loss of muscle mass, osteoporosis, skin atrophy, sterile abscess.

    Uncommon, 1/1000

  • refreshing mental, mood change, severe depression, insomnia.
  • Eye: Glaucom, cataracts.
    • digestive: gastric ulcer and may then puncture and bleed, pancreatitis, bloating, esophageal ulcer.

    Rare, 1/10000

  • Skin: Allergic dermatitis, urticaria, vasoconstriction.
    • nervous: Hurry increased intracranial pressure.

    Other: Anaphylaxis or hypersensitivity and hypersensitivity or similar shock.

    Unknown frequency:

  • Effects on plant nerves: Sleeping or sleepy especially during the first treatment.
  • The anti -cholinergic impact that dries the mucosa, regulating disorders, pupils, heartbeat, fastness, risk of urination.
    • Hypotenary pressure posture.

    Balancing disorders, dizziness, memory loss or concentration.

  • Loss of movement, trembling, more often happening in the elderly.

    • mixed, hallucinations.

    Hypersensitivity reactions: rash, eczema, itching, hemorrhage, urticaria, edema, rarer can cause Quincke edema, anaphylaxis.

    Effects on blood: leukopenia, neutropenia, thrombocytopenia, anemia.

    Instructions on how to handle ADR

    Notify the doctor with unwanted effects when using the drug.

    Most of unwanted effects can often be recovered or reduced by reducing this dose rather than stopping the drug.

    Use oral corticosteroids with food that limit indigestion or digestive tract irritation may occur. Patients with prolonged treatment with corticosteroids at the dose of treatment may have to limit the use of sodium and supplement potassium during treatment.

    Because corticosteroids increase protein catabolism, it may be necessary to increase the protein diet during prolonged treatment. Using calcium and vitamin D can reduce the risk of osteoporosis caused by corticosteroids during prolonged treatment. People with a history or risk factor for stomach ulcers must be taken care of by anti -ulcer drugs (anti -acid drugs, H2 receptor antagonists or proton pump inhibitors). Patients who are using glucocorticoids that have anemia need to think of the causes may be due to stomach bleeding.

    Warnings

    Before using the drug you need to read the instructions carefully and refer to the information below.

    Contraindicated

    Celextavin drugs contraindicated in the following cases:

  • Hypersensitivity to the ingredients of the drug.
  • The risk of urination is associated with prostate urethra disorders.
  • Risk of closed angle glaucom.
  • Relative contraindications: pregnant and lactating women.

    • Precautions when used

  • Older patients are likely to have high posture hypotension, dizziness, drowsiness; Chronic constipation (due to the risk of intestinal obstruction); Swelling of the prostate.
  • Patients with liver failure, severe renal failure, due to the risk of accumulation of drugs.
  • People with congested heart failure, new myocardial infarction, hypertension, diabetes, epilepsy, glaucom, thyroid defect, osteoporosis, stomach ulcers, mental disorders.

    • The ability to drive and operate machinery

    Be cautious when driving or operating machinery due to the ability to cause drowsiness when taking the drug.

    Pregnancy

    Use corticosteroids during pregnancy or in people who are likely to consider the benefits and dangers of the drug on mothers and embryos or fetuses.

    Breastfeeding period

    betamethason Exports into breast milk and can be harmful to children and the drug can inhibit development and cause other unwanted effects, for example, reducing adrenal gland function. Benefits for mothers must be considered with the ability to harm children.

    Drug interaction

    betamethason:

  • paracetamol: corticosteroids touch with liver enzymes, which can increase to form a metabolic substance of toxic paracetamol to the liver. Therefore, the risk of liver poisoning if used with high doses of paracetamol or acting field.
  • 3 -round antidepressants: Do not reduce but can increase mental disorders caused by corticosteroids.
  • Oral diabetes or insulin drugs: glucocorticoid may increase blood glucose levels.
  • glycosid digitalis: simultaneous use may increase the possibility of arrhythmia or toxicity of digitalis and hypotension. Phenobarbital, Phenytoin, Rifampicin or Ephedrin may increase corticosteroid metabolism and reduce their treatment effect.
  • Corticosteroids simultaneously with anticoagulants can increase or reduce anticoagulant effects.
  • The coordination effect of nonsteroidal or alcoholic anti -inflammatory drugs with glucocorticoids can lead to increased occurrence or increased severity of gastrointestinal ulcers. Corticosteroids may increase the concentration of salicylate in the blood.

    • dexclorpheniramin maleat:

    Do not coordinate:

    Alcohol: Increasing the sedative effect of antihistamine H1. A decrease in concentration and alertness can be dangerous when driving or operating machinery. Avoid drinking alcohol and drinks containing alcohol during medication.

    Should note when coordinating:

  • Other central nervous system inhibitors (analgesics and anti -Morphin family, antidepressants have sedative effects, Benzodiazepin, Barbiturat, Clonidin and drugs with them, sleeping pills, methadons, neurony drugs, anxiety): Increased central neurological inhibitors. A decrease in concentration and alertness can be dangerous when driving and operating machinery.
  • Atropine and drugs have the same effect as atropine (Imipramine antidepressants, anti -vibration drugs that have anti -cholinergic effects, anti -spasms that have atropine, disopyramid): Increasing the adverse effects of the Atropine group such as urinary retention, constipation, dry mouth.

    • Storage

    In a dry place, the temperature does not exceed 30 ° C, avoiding light.

    Do not use the drug if: the tablet is discolored, cracked, broken, the drug is torn, the bottle is cracked, losing the label.

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