Celosti 100 treatments for osteoarthritis, rheumatoid arthritis (2 blisters x 10 tablets)

Dosage form Box of 2 blisters x 10 tablets
Specifications Celecoxib
Ingredient Arthritis, rheumatoid arthritis

Ingredient

Composition information	Content
Celecoxib	100mg

Uses

Indications

Treatment of symptoms of osteoarthritis, rheumatoid arthritis in adults.

Supporting treatment to reduce the number of polyps in conventional therapy for treatment of polyps in general - rectal rectal disease.

Acute pain treatment, including pain after surgery, tooth extraction.

Treatment of Phat Nguyen Phat.

Pharmacology

celosti 100 with Celecoxib active ingredient, is a nonsteroidal anti-inflammatory drug, selective inhibitor cyclooxygenase-2 (COX-2), has anti-inflammatory, analgesic, fever. Celecoxib inhibits prostaglandin synthesis, mainly through COX-2 inhibiting effects, reducing premature premature of prostaglandin. Due to not inhibiting COX-1, Celecoxib is less likely to cause side effects on the stomach and platelet mucosa.

pharmacokinetics

absorption:

Celecoxib is quickly absorbed through the gastrointestinal tract. The peak concentration of the plasma of the drug usually reaches 3 hours after taking a single dose of 200 mg at hunger. The concentration of drugs in a stable state in plasma is achieved within 5 days, there is no accumulation.

Distribution:

In plasma treatment concentrations, 97% of Celecoxib is attached to plasma proteins.

Era:

Half lifetime elimination in plasma of Celecoxib after drinking is 11 hours and prolonged in people with kidney failure or liver failure. Celecoxib eliminates about 27% in urine and 57% in feces, less than 3% of the doses are eliminated unchanged.

Before taking Celosti 100 treatments for osteoarthritis, rheumatoid arthritis (2 blisters x 10 tablets)

How to use

oral medication.

Dosage

Bone degeneration - joints:

Take 100 mg/time x 2 times/day or 200 mg/time x 1 time/day.

rheumatoid arthritis in adults:

Take 100 - 200 mg/time x 2 times/day.

Great polyps - rectal:

Take 400 mg/time x 2 times/day.

Pain in general and economic system:

The usual dose in adults: 400 mg/time, followed by 200 mg if necessary in the first day. To continue analgesic, maybe a dose of 200 mg/time x 2 times/day if needed.

Elderly: over 65 years of age does not need dose adjustment. For the elderly under 50 kg, the lowest recommended dose must be used at the beginning of treatment.

People with severe kidney failure and liver failure: do not recommend. For medium liver failure people, a 50%reduction.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Overdose of nonsteroidal anti -inflammatory drugs can cause fleeting, drowsy, nausea, vomiting and epigastric pain. These manifestations are often recovered with supportive treatment. The gastrointestinal bleeding may also occur.

The more rare manifestations are hypertension, acute renal failure, respiratory inhibition and coma. Anaphylactic reactions have been notified to the treatment dose of nonsteroidal anti -inflammatory drugs and may occur during an overdose.

How to handle:

Treatment of symptoms and support. There is no specific antidote. In the first 4 hours after overdose, vomiting therapy and/ or activated carbon, and/ or an osmotic bleach may be useful for patients who have manifested pathology or have taken a large amount of drugs.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Celosti 100, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Digestive system: abdominal pain, diarrhea, indigestion, flatulence, nausea.

Respiratory system: Sore throat, rhinitis, sinusitis, upper respiratory infection.

Central nervous system: Insomnia, dizziness, headache.

DA: Ban Da.

Common disorders: back pain, peripheral edema.

Rare, ADR

Cardiovascular system: fainting, congestive heart failure, ventricular vibration, pulmonary disease, stroke, peripheral mail, thrombosis, vasculitis.

Digestive system: intestinal obstruction, intestinal perforation, gastrointestinal bleeding, bleeding colitis, esophagus, pancreatitis. bile liver system: gallstones, jaundice, hepatitis, liver failure. blood and lymphatic system: thrombocytopenia, granulocytosis, non -regenerated anemia, all bloody hemoglobin, leukopenia.

Metabolism: Hemorrhage reduction.

Central nervous system: loss of air conditioning, paranoia, suicide. kidney: Acute renal failure, interstitial nephritis. skin: Diverse erythema, peeling dermatitis, Stevens - Johnson syndrome. general disorder: bacterial infection, anaphylactic reaction, angioedema.

Not determined frequency

Cardiovascular system: The risk of cardiovascular thrombosis.

Instructions on how to handle ADR

If there is a toxic manifestation of kidneys during treatment, it is necessary to stop the drug, usually the kidney function will return to the level before the treatment after stopping the drug. Liver test may increase (3 times the normal level at the upper limit). This increase may progress or not change or temporarily for a while when continuing the cigarette. But if there is a heavy manifestation of hepatitis (jaundice, manifestation of liver failure, ...) must stop immediately.

In general, when used in normal and short doses, Celecoxib tolerates well.

Warnings

Contraindicated

Celosti 100 contraindications in the following cases:

Sensitive to Celecoxib, Sufonamid.

heart failure, severe liver failure.

Severe renal failure (Creatinine clearance coefficient below 30 ml/minute).

Crohn disease (Crohn's disease, ulcerative colitis).

History of asthma, urticaria, or other allergic reactions after taking aspirin or other nonsteroidal anti -inflammatory drugs.

Caution when using

people with a history of peptic ulcer, gastrointestinal bleeding; History of asthma, allergies when taking aspirin or an nonsteroidal anti -inflammatory drug due to the risk of anaphylaxis.

Elderly, weakened because it is easy to cause gastrointestinal bleeding and often the renal function is impaired due to age. Celecoxib can be toxic to the kidneys, especially when maintaining the blood flow through the kidneys requires the support of the kidney prostaglandin.

People at high risk are people with heart failure, kidney failure or liver failure; people with edema, water retention (heart failure, kidney failure) because of drugs that cause stasis; People with foreign cell loss (due to strong diuretics).

Risk of cardiovascular thrombosis:

Non -steroid anti -inflammatory drugs (NSAIDs), non -aspirin, use systemic sugar, may increase the risk of cardiovascular thrombosis, including myocardial infarction and stroke, which can lead to death. This risk can appear early in the first few weeks of taking the drug and can increase over time. The risk of cardiovascular thrombosis is recorded mainly at high doses.

Doctors need to periodically evaluate the appearance of cardiovascular events, even if the patient has no previous cardiovascular symptoms. Patients need to be warned of symptoms of serious cardiovascular events and need to see a doctor as soon as they appear. In order to minimize the risk of adverse incidents, Celosti 100 is needed at the lowest daily daily doses in the shortest possible time.

The ability to drive and operate machinery

Precautions when using the drug for people who are driving and operating machinery.

Pregnancy

should only use Celecoxib for pregnant women when the maternal benefit is higher than the risk that may occur for the fetus. Do not use Celecoxib in the last 3 months of pregnancy because prostaglandin synthetic inhibitors may have a bad effect on the cardiovascular system of the fetus.

The period of breastfeeding

Because Celecoxib may have serious unwanted effects for breastfeeding, need to consider stopping breastfeeding during medication.

Medicinal interaction

Celecoxib may reduce the anti -hypertension effect of enzyme inhibitors and reduce the effect of increasing the excretion of sodium sodium of Furosemid and Thiazid.

Simultaneous use of Celecoxib and aspirin can lead to increased gastrointestinal ulcer ratio.

Simultaneous use of celecoxib with fluconazole can lead to increased plasma concentrations of celecoxib.

Celecoxib may reduce lithium kidney clearance, increasing lithium concentration in plasma.

Bleeding complications in combination with increased prothrombin time occurred in some elderly patients when used simultaneously with warfarin.

Storage

In a dry place, avoid light, temperatures below 30⁰C.

Other drugs

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