Celosti 200 DHG medicine for treatment of osteoarthritis, rheumatoid arthritis (2 blisters x 10 tablets)
Dosage form Box of 2 blisters x 10 tablets
Specifications Celecoxib
Ingredient Arthritis, rheumatoid arthritis
Ingredient
| Composition information | Content |
| Celecoxib | 200mg |
Uses
indications
Celosti 200 drugs are indicated in the following cases:
Pharmacokinus
Celecoxib's acting mechanism is a selective inhibitor of Cycloxygenase-2 (COX-2), which has anti-inflammatory, pain relief, antipyretic. Celecoxib inhibits prostaglandin synthesis, mainly through COX-2 inhibiting effects, reducing premature premature of prostaglandin. Due to not inhibiting COX-1, Celecoxib is less likely to cause side effects on the stomach and platelet mucosa.
pharmacokinetics
absorption:
Celecoxib is quickly absorbed through the gastrointestinal tract. The peak concentration of the plasma of the drug has been achieved at 2-3 hours after taking a single dose of 200 mg at hunger. The drug concentration in a stable state in plasma is achieved within 5 days; There is no accumulation. Oral bioavailability is 99%capsule.
Distribution:
The ratio of cohesion with plasma proteins is about 97%, Celecoxib is not prioritized to erythrocytes.
Metabolism:
Celecoxib is metabolized mainly through Cytocrom P450 2C9. Three metabolic products do not have the effect of inhibiting COX-1 or COX-2 identified in human plasma is the most alcohol, carboxylic acid and its form of glucuronic.
Era:
Celecobxid elimination is mainly due to metabolic through the liver with
Before taking Celosti 200 DHG medicine for treatment of osteoarthritis, rheumatoid arthritis (2 blisters x 10 tablets)
How to useuse orally, drink with food or not.
For patients with difficulty swallowing capsules, it is possible to put the amount of drugs in pills into smoothie, porridge, yogurt or crushed bananas to drink.
Due to the risk of cardiovascular disease, which may increase with the dose and time of drug use, the lowest dose should be used in the shortest time.
Dosage
adults
Symptomatic treatment in osteoarthritis:
200mg used single or 100mg doses, 2 times daily.
Symptomatic treatment in rheumatoid arthritis:
100mg or 200 mg, 2 times daily.
Age -joint spondylitis:
200mg used single or 100mg doses, 2 times daily. Some patients may be better if they use a total daily dose of 400mg.
Acute pain control:
The starting dose of 400 mg, taking an additional 200mg of the first day if necessary. The following days, recommend using 200mg, 2 times daily when needed.
Treatment of prospect:
The starting dose of 400 mg, taking an additional 200mg of the first day if necessary. The following days, recommend using 200mg 2 times daily when needed.
The usual dose in adults: 400 mg/time, followed by 200 mg if necessary in the first day. To continue analgesic, can give the dose of 200 mg 2 times daily if necessary.
People with poor metabolism CYP2C9:
Be careful when using Celecoxib. Start with the lowest recommended dose of treatment.
Use in combination with fluconazole:
Should be used with ½ recommended dose.
Children 2 years and older
Teenage spontaneous arthritis:
The following weight is as follows
Elderly
over 65 years of age does not need dose adjustment. For the elderly under 50 kg, the lowest recommended dose must be used at the beginning of treatment.
Hepatic failure
No dose adjustment for patients with mild liver failure. Use ½ dose for patients with medium liver failure. There is no study in patients with severe liver failure.
Renal failure
No dose adjustment for patients with mild and medium renal failure. There is no study in patients with severe renal failure.
Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.
What to do when overdose?
Overdose of nonsteroidal anti -inflammatory drugs can cause fleeting, drowsy, nausea, vomiting and epigastric pain. These manifestations are often recovered with supportive treatment. Also gastrointestinal bleeding.
The more rare manifestations are hypertension, acute renal failure, respiratory inhibition and coma. Anaphylactic reactions have been notified to the treatment dose of nonsteroidal anti -inflammatory drugs and may occur during an overdose.
How to handle:
Treatment of symptoms and support. There is no specific antidote. In the first 4 hours after overdose, vomiting therapy and/ or activated carbon, and/ or an osmotic bleach may be useful for patients who have manifested pathology or have taken a large amount of drugs.
What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.
Side Effects
When using Celosti 200, you may experience unwanted effects (ADR).
Common, ADR> 1/100
DA: Ban Da.
Uncommon, 1/1000 Vascular disorders: deep vein thrombosis, hematoma. Rare, ADR blood and lymphatic system: decreased crane, granulocytosis, non -regenerated anemia, all bloody hematoma, leukopenia. Instructions on how to handle ADR If there is a toxic manifestation of kidneys during treatment, it is necessary to stop the drug, usually the kidney function will return to the level before the treatment after stopping the drug. The liver test may increase (3 times the level of injury at the upper limit). This increase may progress, or unchanged or temporarily only for a while when continuing the cigarette. But if there is a heavy manifestation of hepatitis (jaundice, manifestation of liver failure, ...) must stop immediately. In general, when used in normal and short doses, Celecoxib tolerates well.
Warnings
contraindicated
Celosti 200 drugs contraindicated in the following cases:
There is a history of asthma, urticaria, or other allergic reactions after taking aspirin or other nonsteroidal anti -inflammatory drugs.
Be cautious when using
Heart thrombosis:
Non -steroid anti -inflammatory drugs (NSAIDs), non -aspirin, use systemic sugar, may increase the risk of cardiovascular thrombosis, including myocardial infarction and stroke, which can lead to death. This risk can appear early in the first few weeks of taking the drug and can increase over time.
The risk of cardiovascular thrombosis is recorded mainly in high doses. Doctors need to periodically assess the appearance of cardiovascular events, even if the patient has no previous cardiovascular symptoms. Patients need to be warned of symptoms of serious cardiovascular events and need to see a doctor as soon as they appear. To minimize the risk of adverse incidents, Celosti 200 is needed at the lowest daily daily doses in the shortest possible time.
Cardiovascular effects:
Cardiovascular thrombosis: Celecoxib can increase the risk of serious cardiovascular thrombosis, myocardial infarction and stroke, which can be fatal. All NSAIDs may have this risk. This risk may increase according to the dose, time of use and cardiovascular risk factors.
Patients with cardiovascular history may be at higher risk. To minimize the risk of unwanted effect on the heart, the lowest dose should be used as effective and during the time as possible.
Celecoxib is not an alternative to aspirin in preventing blockages - cardiovascular thrombosis due to lack of platelet function.
Hypertension:
Celecoxib may start an increase in hypertension or worsen the inherent hypertension. Strict blood pressure monitoring is required to start treating with Celecoxib as well as during treatment.
Translation and edema:
Need to closely monitor patients with congestive or hypertension. Be cautious when using Celecoxib in patients who have suffered from heart, edema or other conditions may be worse due to fluid and edema.
Effects on gastrointestinal tract:
Perforation, ulcers or gastrointestinal bleeding up and below, especially the elderly, patients with cardiovascular disease, taking aspirin, corticosteroids ...
Effects on the kidneys:
Celecoxid can be toxic to kidneys, need to be cautious when starting treatment for dehydration.
Progressive kidney disease:
Need to closely monitor kidney function in patients with renal disease progression when using Celecoxib.
Serious skin reactions:
often rare.
Use simultaneously with oral blood clots:
When used simultaneously with Celecoxib increases the risk of bleeding and should be cautious when used.
CYP2D6 inhibition:
Need to reduce the dose of drugs metabolized in CYP2D6 when used with Celecoxib.
Related to excipients:
Due to lactose excipients in the ingredients, should not be used in patients with lactose tolerance, lactase deficiency or glucose-galctose absorption disorders.
The ability to drive and operate machinery
There has been no research on influence on the ability to drive and operate machinery, which can be considered as a drug without influence.
Pregnancy
There is no research in pregnant women. Like other prostaglandin synthesis inhibitors, which can cause helplessness and early aortic muscle, should avoid using Celecxibib in the third quarter of pregnancy. Only use when the potential benefits for the mother surpasses the potential risk to the fetus.
Lactation period
very few Celecoxibs are excreted into milk. Because Celecoxib may have serious unwanted effects for breastfeeding, need to consider stopping breastfeeding during medication.
Drug interaction
Bleeding complications combined with increased prothrombin time occurred in some elderly patients when using simultaneously with warfarin.
Celecoxib may reduce lithium kidney clearance, increasing lithium concentration in plasma.
Simultaneous use of Celecoxib and aspirin can lead to increased gastrointestinal ulcer ratio.
Celecoxib may reduce the anti -hypertension effect of enzyme inhibitors.
Celcoxib may increase the risk of kidney toxicity when used with cyclosporin.
Simultaneous use of Celecoxib with fluconazole/ ketoconazole may lead to increased plasma concentrations of celecoxib.
Dextromethorphan and Metoprolol: Celecoxib increases the plasma concentrations of these drugs.
Celecoxib can reduce the effect of increasing the excretion of sodium sodium of Furosemid and Thiazid.
Cavalry: Not known.
Storage
In a dry place, avoid light, temperature below 30 ° C.
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