Cephalexin 250mg Vidipha medicine for infections (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Cephalexin
Ingredient Sore throat, rhinitis, otitis media, urinary tract infections, skin infections and soft tissue, gonorrhea, upper respiratory tract infections

Ingredient

Composition information	Content
Cephalexin	250mg

Uses

indications

Cephalexin 250 drug is indicated in the following cases:

Respiratory infections: Acute and chronic bronchitis, bacterial bronchodilator. Preventive treatment for recurrent urinary tract infections. Learning

cefalexin is antibiotics of the first generation cephalosporin group, which has bactericidal effects by inhibiting the synthesis of bacterial cell walls.

Cefalexin is sustainable with staphylococcus penicilinase, thus working with staphylococcus aureus strains of penicillin -resistant penicillin (or ampicillin). Cefalexin has the effect of printing in vitro on the following bacteria: Streptococcus beta, blood-soluble, staphylococcus, including coagulase strains (+), coagulase (-) and penicilinase, streptococcus pneumoniae, some Escherichia coli, Proteus Mirabilis, some Klebsella SPPPS SPPPSLLI Branhamella Catnrhalis, Shigella, Haemophilus Influenzae often decreases sensitivity.

Cefalexin also works on most of the amoeba -resistant e.coli.

Most of the Enterococcus strains (Streptococcus Faecalis) and a few strains of staphylococcus resistance Cefalexin. Proteus indol is positive, some Enterobacter spp, Pseudomonas Aeruginosa, Bacteroides spp. also see resistance. When testing in vitro, Staphylococcus shows the cross -resistance between cefalexin and methicillin antibiotics.

Dynamic pharmacokinetics

cefalexin absorb completely in the digestive tract and reach peak plasma concentrations around 9 and 18 micrograms/ml after an hour with the corresponding oral dose of 250 and 500 mg, double the double dose reaches double concentration. Drinking Cefalexin along with food can slow down the ability to absorb but the total amount of absorption drugs does not change.

There are up to 15% of cefalexin doses associated with plasma proteins. The half -life of plasma in adults has a normal renal function of 0.5 - 1.2 hours, but in newborns longer (5 hours) and increases when renal function decreases.

cefalexin is widely distributed throughout the body, but the amount in cerebrospinal fluid is negligible. Cefalexin passes the placenta and excreted breast milk with low concentrations. Cefalexin is not metabolized. The distribution of Cefalexin is 18 l/1.78 m2 of the body area.

Over 90% of the drug is eliminated into the urine in the form of unchanged in the first 8 hours through glomerular filtration and excreted in the renal tubules, at a dose of 500 g of cefalexin, the concentration of urine is higher than 1 mg/ml. Probenecid slowed the excretion of cefalexin in the urine. Cefalexin can be found at a concentration that has a therapeutic effect in bile and some cefalexin can be eliminated by this way.

Cefalexin is eliminated through dialysis and peritoneal dialysis (20% - 50%).

Before taking Cephalexin 250mg Vidipha medicine for infections (10 blisters x 10 tablets)

How to use

cefalexin 250 mg oral.

Dosage

Adults: Use 250 - 500 mg 6 hours/time, depending on the level of infection. The dose can be up to 4 g/day.

Note: The treatment time should last at least 7 to 10 days. In complex, recurrent and chronic urinary infections, treatment should be treated for 2 weeks (1 g/time x 2 times/day). For gonorrhea, the only dose of 3 g with 1 g of probenecid for men or 2 g with 0.5 g of probenecid for women. Used in combination with probenecid will extend the excretion time of cefalexin and increase serum concentration from 50 - 100%.

Adjust the dose when kidney failure:

Creatinine clearance (TTC)

Creatinin (CHT)

Maximum maintenance dose

TTC: ≥ 50 ml/min.

CHT: ≤ 132 micromol/liter.

1 g, 4 times in 24 hours.

CHT: 133 - 295 micromol/liter.

1 g, 3 times in 24 hours.

TTC: 19 - 10 ml/min.

CHT: 296 - 470 micromol/liter.

500 mg, 3 times in 24 hours

TTC: ≤ 10 ml/min.

CHT: ≥ 471 micromol/liter.

250 mg, 2 times in 24 hours.

Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Symptoms

After an acute overdose, most of them only cause nausea, vomiting and diarrhea, but can cause hypersensitivity and seizures, especially in patients with renal failure.

Overdose

It is necessary to consider the overdose of many drugs, abnormal drug interaction and pharmacokinetics.

No need to wash the stomach, unless you have taken Cefalexin 5 - 10 times the normal dose.

Dialysis can help eliminate drugs from blood, but often do not need.

Protects the respiratory tract of patients, support ventilation and infusion. Give activated carbon many times instead or add to gastric lavage. Need to protect the respiratory tract of the patient while gastrointestinal or active carbon.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Cephalexin 250, you may experience unwanted effects (ADR).

The unwanted reaction rate is about 3-6% of the entire patient.

Common, ADR> 1/100

Digestive: diarrhea, nausea.

Uncommon, 1/1000

Blood: Eosin hypernagus.

skin: rash, urticaria, itching. liver: Increased liver transaminase recovery.

Central nervous system: anxiety, confusion, dizziness, fatigue, sensory, headache.

Rare, ADR

Systemic: headache, dizziness, anaphylactic reaction, fatigue.

blood: neutrophils, platelets. digestive: digestive disorders, abdominal pain, fake colitis. DA: Stevens - Johnson syndrome, diverse roses, poisoned epidermal necrosis (Lyell syndrome), edema. liver: hepatitis, jaundice, alt, AST increased.

urinary - genital: Itchy genitals, vaginitis, interstitial nephritis.

Other: allergic reactions, anaphylaxis.

Instructions on how to handle ADR

Cefalexin stop. If allergies or hypersensitivity are serious, it is necessary to conduct supportive treatment to ensure ventilation and use epinephrin, oxygen, intravenous corticosteroids.

If colitis has a mild mild fake membrane, it usually only needs to stop the drug, medium and severe cases, be aware of the use of fluids and electrolytes, protein supplements and antibiotic treatment that treat c.difficide colitis.

Notify the doctor with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Cephalexin 250 drug contraindicated in the following cases:

Patients with a history of allergies to antibiotics of cephalosporin or other ingredients of the drug.

Do not use cephalosporin for patients with a history of anaphylaxis due to penicillin or other serious reactions through the intermediary globulin.

Be cautious when using

cefalexin is usually well tolerated even in patients with penicillin allergies, but there are also very few cross -allergies.

The long -term use of cefalexin can cause over -sensitive bacteria (for example, Candida, Enterococcus, Clostridium difficile), in this case, it should be stopped. There has been a notice of fake colitis when using broad -spectrum antibiotics, so it is necessary to pay attention to the diagnosis of this disease in patients with severe diarrhea during or after antibiotics.

Like antibiotics eliminated mainly through the kidneys, when renal failure, the dose of cefalexin must be reduced.

In patients with cefalexin, a false positive reaction may be reacted when testing the urinary glucose with a "benedict" solution, the "fehling" solution or the "clinitest", but for enamel tests, it is not affected.

There is a notice of cefalexin causing positive positive for Coombs.

The ability to drive and operate machines

drugs do not affect the driver and operate machinery.

Pregnancy

Experimental research and clinical experience have not shown signs of toxicity for pregnancy and teratogenic. However, only cefalexin should be used for pregnant people when they need it.

The period of breastfeeding

Cefalexin concentration in breast milk is very low. Should consider stopping breastfeeding during the time when the mother uses Cefalexin.

Drug interaction

High -dose cephalosporin use with other poisonous drugs such as aminoglycosides or strong diuretics (e.g. Furosemid, ethacryric acid and piretanid) can adversely affect kidney function. Clinical experience shows no problem with cefalexin at the recommended dose.

cholestyramin attached to cefalexin in the intestine slows down their absorption.

Probenecid increases serum levels and increases the selling time of cefalexin.

In a study of 12 healthy people using a single dose of 500 mg Cefalexin and 500 mg of metformin, CMAX and AUC of Metformin in plasma increased by the average encroachment of 34%and 24%, metformin removal in the kidney average is 14%. There is no side effects reported in 12 healthy people in this study.

There is no information on the interaction of cefalexin and metformin after multiple doses. The clinical significance of this study is unclear, especially without the case of "lactic acidosis" that is reported related to simultaneous treatment Metformin and Cefalexin.

Hypotension has been described in patients using cytotoxic drugs in leukemia when taking Gentamycin and Cefalexin.

Storage

In a dry place, temperatures below 30 ° C, avoid light.

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