Cephalexin 500mg Pharbaco medicine for infection treatment (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Cephalexin
Ingredient Tonsillitis, sore throat, otitis media, sinusitis, urinary tract infections, genital infections, skin and soft tissue infections

Ingredient

Composition information	Content
Cephalexin	500mg

Uses

indications

Cephalexin 500 mg drug is indicated for use in cases of treatment of infections caused by sensitive bacteria, but not indicated to treat severe infections:

Acute and chronic bronchitis, bacterial bronchodilator.

otitis media, osteoarthritis, sinusitis, cavity tonsils and sore throat.

cystitis, prostatitis, bacterial and gynecological infections, gonorrhea.

Skin infections, soft tissue, bones and teeth.

Pharmacology

Cephalexin is the first -generation cephalosporin antibiotic, which has bactericidal effects by inhibiting the synthesis of bacterial cell walls. Cephalexin is an antibiotic, antibacterial spectrum like the first generation cephalosporin.

Cephalexin is sustainable with staphylococcus penicilinase, thus working on staphylococcus aureus strains of penicillin -resistant penicillin (or ampicilin). Cephalexin has the effect of printing in vitro on the following bacteria: Streptococcus beta blood-soluble, staphylococcus, including coagulase strains (+), coagulase (-) and penicilinase, streptococcus pneumoniae, some Escherichia coli, Proteus Mirabilis, some Klebsella SPPPS SPPPSLLA Branhamella Catnrhalis, Shigella, Haemophilus Influenzae often decreases sensitivity.

cephalexin also works on most of the ampicillin -resistant e.coli.

Most of Enferococcus strains (Streptococcus Faecalis) and a few staphylococcus strains of Cephalexin resistant. Proteus indol is positive, some Enterobacter spp., Pseudomonas Aeruginosa, Bacteroides spp.

When testing in vitro, Staphylococcus shows the cross -resistance between cephalexin and methicilin antibiotics.

Dynamic pharmacokinetics

cephalexin are almost completely absorbed in the digestive tract and reach the peak concentration of plasma around 9 and 18 mg/ml after an hour with the corresponding oral doses of 250 and 500 mg, double the double dose reaches double concentration.

Take Cephalexin along with food can slow down the ability to absorb but the total absorption dose does not change. Up to 15% of cephalexin dose is connected to plasma proteins. Half of the lifetime in adults with normal kidney function is 0.5 - 1.2 hours, but in newborns longer (5 hours) and increases when renal function decreases.

cephalexin is widely distributed throughout the body, but the amount in cerebrospinal fluid is negligible. Cephalexin passes through the placenta and excretes breast milk with low concentrations. Cephalexin is not metabolized. The distribution of Cephalexin is 18 liters/1.78 m2 of the body area. About 80% of the dosage deducting urine in the form of unchanged in the first 6 hours through glomerular filtration and excretion in the renal tubules, with a dose of 500 mg of cephalexin, the concentration of urine is higher than 1 mg/ml.

ProBEBECID slowly excreted cephalexin in the urine. Cephalexin can be found at concentrations that have a therapeutic effect in bile and some cephalexin can be eliminated by this way.

Cephalexin is eliminated through dialysis and peritoneal dialysis (20% - 50%).

Before taking Cephalexin 500mg Pharbaco medicine for infection treatment (10 blisters x 10 tablets)

How to use

Cephalexin 500 mg drug is used by oral.

Dosage

Children over 15 years old and adults: Take oral. Common dose: 1 tablet, 6 hours/time. The dose may be up to 4 g/day for severe bacterial infections or due to infections.

Sore throat and tonsillitis: 1 tablet, 12 hours/time, taking the drug at least 10 days.

Skin infections and skin structure: 1 tablet, 12 hours/time.

Urinary tract infections: To treat uncomplicated cystitis, usually use 1 tablet, 12 hours/time, for 7-14 days.

Adjust the dose in people with renal failure.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Symptoms

Nausea, vomiting, diarrhea, can cause hypersensitivity and seizures, especially in people with kidney failure.

Handling

No stomach was needed, unless you have taken Cephalexin 5 - 10 times the normal dose. Protect respiratory tract for patients, support ventilation and infusion. Give activated carbon many times instead or add to gastric lavage. Need to protect the respiratory tract of the patient while gastrointestinal or active carbon.

What to do when forgetting 1 dose?

Not recorded.

Side Effects

When using Cephalexin 500 mg, you may experience unwanted effects (ADR).

Common

diarrhea, nausea.

rarely

Eosin bloody, rash, urticaria, itching, liver transaminase is recovered.

rarely

Headache, dizziness, anaphylactic reaction, fatigue, neutropen leukemia, thrombocytopenia, digestive disorders, abdominal pain, fake colitis, Steven - Jonhson syndrome, diverse Hong Ban, Lyell syndrome, rhyme, hepatitis, cholest jaundice, genital itching, vaginitis, interstitial renal inflammation.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Cephalexin 500 mg drug is contraindicated in the following cases:

Patients with a history of allergies to antibiotics of cephalosporin.

Patients with a history of anaphylaxis due to penicillin or other serious reactions through IgE immun globulin intermediaries.

Hypersensitivity to cephalexin and other ingredients of the drug.

Be cautious when using

cephalexin is usually well tolerated even in patients with allergies to penicillin, but there are also very few cross -allergies.

Use of long -term cephalexin can cause excessive growth of uncertainty bacteria, this case should stop the drug.

Pay attention to the diagnosis of fake colitis in patients with severe diarrhea during or after antibiotics.

Must reduce cephalexin dose suitable for kidney failure.

In patients with cephalexin may have a false positive reaction when testing the urinary glucose with a benedict solution, a fehling or clinitest solution, but with enzyme tests, it is not affected.

There is a notice of Cephalexin that positive for Coombs.

Be cautious when used in the first months of pregnancy.

The ability to drive and operate machinery

The drug can cause some unwanted effects such as headache, dizziness, fatigue, nausea. So be cautious when used for people who are driving and operating machinery.

Pregnancy

Experimental research and clinical experience have not shown signs of toxicity for pregnancy and teratogenic. However, only cephalexin should only be used for pregnant people.

The period of breastfeeding

Cephalexin concentration in breast milk is very low. However, it is still recommended to consider stopping breastfeeding during the time when the mother uses Cephalexin.

Drug interaction

High -dose cephalexin use with other drugs also poisoned on the kidneys such as aminoglycosides, strong diuretics (Furosemid, etharynic acid, piretanid) that can adversely affect kidney function.

cephalexin reduces the effect of estrogen in conception pills.

cholestyramin attached to cephalexin in the intestine slows down their absorption.

Probenecid increases serum levels and increases the selling time of cephalexin.

Storage

in a dry place, avoiding light. The temperature does not exceed 30 ° C.

Other drugs

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