Cephalexin 500mg Vidipha medicine for infection treatment (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Cephalexin
Ingredient Vidipha

Ingredient

Composition information	Content
Cephalexin	500mg

Uses

indications

cephalexin 500mg drug is indicated in the following cases:

Treatment of bacterial infections caused by sensitive bacteria, but does not specify the treatment of severe bacterial infections:

Lower respiratory infections: Acute and chronic bronchitis, bacterial bronchodilator.

Ear - nose - throat infection: otitis media, osteoarthritis, sinusitis, cavity tonsils and sore throat.

Urinary - genital inflammation: cystitis and prostatitis. Preventive treatment for recurrent urinary tract infections.

Property and gynecological infections.

Skin infection, soft tissue and bone.

Gonorrhea (when penicillin is not suitable).

tooth infection.

Preventive treatment for penicillin replacement for patients with heart disease must be treated.

Pharmacokic

cephalexin is the first -generation cephalosporin antibiotic, which has bactericidal effects by inhibiting the synthesis of bacterial cell shells. Cephalexin is an antibiotic, antibacterial spectrum like the first generation cephalosporin.

Cephalexin is sustainable with staphylococcus penicilinase, thus working on staphylococcus aureus strains of penicillin -resistant penicillin (or ampicilin). Cephalexin has the effect of in vitro on the following bacteria: Streptococcus beta blood-soluble, staphylococcus, including coagulase strains (+), coagulase (-) and penicilinase. Streptococcus Pneumoniae, some Escherichia Coli, Proteus Mirabilis, some Klebsiella spp. Branhamella Catnrhalis, Shigella, Haemophilus Influenzae often decreases sensitivity.

cephalexin also works on most of the ampicillin -resistant e.coli.

Most Enterococcus strains (Streptococcus Faecalis) and a few staphylococcus strains are resistant to cephalexin. Proteus indol is positive, some Enterobacter spp., Pseudomonas Aeruginosa, Bacteroides spp. When testing in vitro, Staphylococcus shows cross -resistance between cephalexin and methicilin antibiotics.

According to data (ASTS) 1997, Cephalexin works with Staphylococcus aureus, Salmonella, E.coli with a resistance rate of about 50%, Proteus has a resistance rate of about 25%, Enterobacter has a resistance rate of about 23%, Pseudomonas Aeruginosa has a resistance rate of about 20%.

pharmacokinetics

absorption:

Cephalexin is completely absorbed through the gastrointestinal tract and reaches the peak concentration of plasma around 9 and 18μg/ml after 1 hour with the corresponding dose of 250 and 500mg respectively; Double dose reaches double peak concentration.

Cephalexin drinking and food can slow down but the total amount of drugs absorb does not change. Up to 15% of the drug is associated with plasma proteins. Half of the lifetime in adults with normal kidney function is 0.5 - 1.2 hours, but in newborns longer (5 hours) and increases when renal function decreases.

Distribution:

cephalexin is widely distributed throughout the body but the amount in cerebrospinal fluid is negligible. Cephalexin passes through the placenta and excretes breast milk with low concentrations. The distribution of Cephalexin is 18 liters/1.78m2 of body area.

Metabolism:

Cephalexin is not metabolized.

Era:

About 80% of the dosage of excretion in the urine in the form of unchanged in the first 6 hours through the glomerular filtration and excretion in the renal tubules, with the dose of 500mg cephalexin, the concentration of urine is higher than 1mg/ml. ProBEBECID slowed the excretion of cephalexin in the urine.

Can find cephalexin at concentrations that have a therapeutic effect in bile and some cephalexin can be eliminated by this way. Cephalexin is eliminated through dialysis and peritoneal dialysis (20% - 50%).

Before taking Cephalexin 500mg Vidipha medicine for infection treatment (10 blisters x 10 tablets)

How to use

Used by oral.

Dosage

Adults: 250 - 500mg 6 hours/1 time, depending on the level of infection, the dose may be up to 4g/day.

Elderly: Need to assess the level of renal failure.

Note: The treatment time should last at least 7 to 10 days, but in complex, recurrent urinary infections, chronic, should be treated for 2 weeks (1g/time, 2 times a day). For gonorrhea, usually using 3G doses with 1g probenecid for men or 2g with 0.5g of probenecid for women. Used in combination with probenecid will extend the excretion time of cephalexin and increase serum concentration from 50 - 100%.

Dose for kidney failure:

Adjust the dose when kidney failure:

Creatinine clearance ≥ 50ml/min, serum creatinine (CHT) 132 micromol/l, maintenance dose maximum 1g, 4 times in 24 hours.

Creatinine clearance is 49 - 20ml/min, CHT is 133 - 295 micromol/l, maintenance dose up to 1g, 3 times in 24 hours.

Creatinine clearance is 19 - 10ml/min, CHT: 296 - 470 micromol/l, maintenance dose up to 500mg, 3 times in 24 hours.

Creatinine clearance

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do you do when overdose?

Overdose treatment should consider the possibility of overdose of many drugs, abnormal drug interaction and pharmacokinetics of patients.

Processing:

Protects the respiratory tract of the patient, supports ventilation and infusion, drinks activated carbon several times or added to the stomach, need to protect the respiratory tract of the patient while lavely or using activated carbon. When the poisoning is overdose, there is no need to wash the stomach, unless it is taken by Cephalexin 5-10 times the normal dose. Dialysis can help eliminate drugs from blood, but often do not need.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Cephalexin 500mg, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Digestive system: diarrhea, nausea.

Uncommon, 1/1000

Systemic body: Eosiny white blood cells, rash, urticaria, itching.

Digestive system: Increased liver transaminase recovery.

Rare, 1/10000

Systemic: headache, dizziness, anaphylactic reaction, fatigue, neutropen leukemia, thrombocytopenia, abdominal pain.

Digestive system: Palmitis, hepatitis, jaundice, bile skin, digestive disorders. DA: Stevens - Johnson syndrome, diverse roses, poisoned epidermal necrosis (Lyell syndrome), edema.

Kidney system, urinary tract: Itchy genitals, vaginitis, interstitial nephritis.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Cephalexin 500mg drug is contraindicated in the following cases:

Patients with a history of allergies to antibiotics of cephalosporin.

Patients have a history of antimathematics due to penicillin or other serious reactions through IgE immunoglobulin intermediaries.

Be cautious when used

cephalexin is often well tolerated even patients with penicillin allergies, but there are also very few cross -allergies.

Using long -term cephalexin can cause excessive growth of uncertainty bacteria, in this case should stop the drug.

Like with antibiotics eliminated mainly through the kidneys, when renal failure, the dose of cephalexin must be reduced.

Pay attention to the diagnosis of fake colitis in patients with severe diarrhea during or after antibiotics.

Precautions in the first months of pregnancy.

cephalexin causes positive positive Coombs.

The ability to drive and operate machinery

Caution when driving or operating machinery because the drug can cause unwanted effects such as headache, dizziness, fatigue.

Pregnancy

Experimental research and clinical experience have not shown signs of toxicity for pregnancy. However, only cephalexin should be used for pregnant women when they need it.

The period of breastfeeding

Cephalexin concentration in breast milk is very low. However, it should still be considered a temporary breastfeeding during the time that the mother uses Cephalexin.

Drug interactions

use high -dose cephalosporin with other drugs that are also poisonous with kidneys (aminoglycosides) or strong diuretic (Furosemid, ethacrynic acid and piretanid) that can adversely affect kidney function.

cephalexin reduces the effects of estrogen in oral contraceptives.

cholestyramin attached to cephalexin in the intestine slows down their absorption.

Probenecid increases serum levels and increases the half -life of cephalexin.

Storage

Leave a dry place, the temperature does not exceed 30 ° C, avoiding light.

To be out of reach of children.

Other drugs

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