Cephalexin MKP 500 medicine for infections (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Cephalexin
Ingredient Tonsillitis, sore throat, sinusitis, urinary tract infections, genital infections, skin and soft tissue infections

Ingredient

Composition information	Content
Cephalexin	500mg

Uses

Indications

Cephalexin MKP drugs are indicated in the following cases:

Treatment of infections caused by sensitive bacteria:

Lower respiratory infections: Acute and chronic bronchitis, bacterial bronchodilator;

Ear-nose-nose infection: otitis media, osteoarthritis, sinusitis, cavity tonsils and sore throat;

Urinary tract infections: cystitis and prostatitis. Preventive treatment for recurrent urinary tract infections;

Property and gynecological infections;

Skin infection, soft tissue and bone; gonorrhea;

Tooth infection;

Preventive treatment for penicillin replacement for patients with heart disease must be treated.

Pharmacology

cephalexin is a semi -synthetic cephalosporin antibiotic, which has bactericidal effects by inhibiting synthesis of bacterial cells.

cephalexin is sustainable with the act of penicillinase of staphylococcus, so the impact on Staphylococcus aureus is not sensitive to penicillin. Cephalexin has the effect of printing Vitro on the following bacteria: Streptococcus beta hemolysis; Staphylococcus, including coagulase strains (+), coagulase (-) and penicillinase; Streptococcus Pneumoniae, some Escherichia Coli; Proteus Mirabilis, some Klebsiella spp., Branhamella Catnrhalis; Shigella. Cephalexin is also active in most E. coli that has resisted ampicillin.

pharmacokinetics

absorption:

Cephalexin is completely absorbed through the gastrointestinal tract and reaches the peak concentration of plasma around 9 and 18μg/ml after 1 hour with the corresponding dose of 250 and 500mg respectively; Double dose reaches double peak concentration. Drinking Cephalexin and food can slow down but the total amount of drugs absorb does not change. Up to 15% of the drug is associated with plasma proteins. The half -life of the drug in plasma is about 1 hour, increasing when the kidney function decreases.

Distribution:

cephalexin is widely distributed throughout the body but the amount in cerebrospinal fluid is negligible. Cephalexin passes the placenta and excreted breast milk with low concentrations.

Metabolism:

Cephalexin is not metabolized.

Era:

About 80% of the dosage of excretion through urine in the form of unchanged in the first 6 hours through glomerular filtration and excretion in the renal tubules.

Before taking Cephalexin MKP 500 medicine for infections (10 blisters x 10 tablets)

How to use

This type of drug is suitable for adults and children> 6 years old.

Used orally.

Dosage

Adults:

Take 2 - 4 capsules or 1-2 tablets 500mg/time, 3-4 times a day.

Children:

Take 25 - 50mg/kg/day, divided 3-4 times.

normal treatment time from 7 to 10 days.

Adjust the dose when kidney failure:

Creatinin clearance> 50ml/min, maintenance dose up to 1g, 4 times in 24 hours.

Creatinine clearance is 49 - 20ml/min, maintenance dose up to 1g, 3 times in 24 hours.

Creatinine clearance is 19 - 10ml/min, maintenance dose up to 500mg, 3 times in 24 hours.

Creatinine clearance

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do you do when overdose?

Overdose treatment should consider the possibility of overdose of many drugs, abnormal drug interaction and pharmacokinetics of patients.

Processing:

Protects the respiratory tract of the patient, supports ventilation and infusion, drinks activated carbon several times or adds to the stomach, needs to protect the respiratory tract of the patient while taking the stomach or using activated carbon.

When the poisoning is overdose without gastric lavage, unless taken Cephalexin 5 - 10 times the normal dose. Dialysis can help eliminate drugs from blood, but often do not need.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Cephalexin MKP, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Digestive system: diarrhea, nausea.

Uncommon, 1/1000

Systemic body: Eosiny white blood cells, rash, urticaria, itching.

Digestive system: Increased liver transaminase recovery.

Rare, 1/10000

Systemic: headache, dizziness, anaphylactic reaction, fatigue, neutropen leukemia, thrombocytopenia, abdominal pain.

Digestive system: Palmitis, hepatitis, jaundice, bile skin, digestive disorders. DA: Stevens - Johnson syndrome, diverse roses, poisoned epidermal necrosis (Lyell syndrome), edema.

Kidney system, urinary tract: Itchy genitals, vaginitis, interstitial nephritis.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Cephalexin MKP drug is contraindicated in case of sensitivity to penicillin, cephalosporin.

Be cautious when used

cephalexin is often well tolerated even patients with penicillin allergies, but there are also very few cross -allergies.

Using long -term cephalexin can cause excessive growth of uncertainty bacteria, in this case should stop the drug.

Like with antibiotics eliminated mainly through the kidneys, when renal failure, the dose of cephalexin must be reduced.

Pay attention to the diagnosis of fake colitis in patients with severe diarrhea during or after antibiotics.

The ability to drive and operate machinery

Caution when driving or operating machinery because the drug can cause unwanted effects such as headache, dizziness, fatigue.

Pregnancy

Precautions when using cephalexin for pregnant women.

breastfeeding period

Precautions when using cephalexin for nursing women.

Drug interaction

Because cephalosporin antibiotics such as cephalexin only act on proliferative bacteria, should not combine them with bactericidal antibiotics.

When combined with strong diuretic (ethacrynic acid, Furosemide) or antibiotics with kidney toxicity (aminoglycoside, polymyxin, colistin), cephalexin may cause more kidney toxicity.

Probenecid increases serum concentration and semi -waste time of cephalexin.

As other broad -spectrum antibiotics, cephalexin reduces the effects of contraceptives containing estrogen.

Storage

The dry place (moisture

To be out of reach of children.

Other drugs

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