Cephalexin MKP 500 mekophar medicine for infection treatment (100 tablets)

Dosage form Box of 100 capsules
Specifications Cephalexin
Ingredient Tonsillitis, pharyngitis, otitis media, urinary tract infections, genital infections, skin and soft tissue infections

Ingredient

Composition information	Content
Cephalexin	500mg

Uses

Indications

Cephalexin 500mg Mekophar 100V drug is indicated in the following cases:

Cephalexin is indicated in the treatment of infections caused by sensitive bacteria:

Lower respiratory infections: Acute and chronic bronchitis, bacterial bronchodilatoma.

Ear - nose - throat infection: otitis media, osteoarthritis, sinusitis, tonsillitis and sore throat.

Urinary - genital inflammation: cystitis and prostatitis. Preventive treatment for recurrent urinary tract infections.

Skin infection, soft tissue and bone.

Preventive treatment for bacterial infections.

Pharmacokology

cephalexin is a semi -synthetic cephalosporin antibiotic, which has bactericidal effects by inhibiting synthetic bacterial cells.

cephalexin is sustainable with the act of penicillinase of staphylococcus, so the impact on Staphylococcus aureus is not sensitive to penicillin. Cephalexin has the effect of printing in vitro on the following bacteria: Streptococcus beta blood -soluble, Staphylococcus - including coagulase strains (+), coagulase ( -) and penicilinase, streptococcus pneumoniae, some Escherichia coli, Proteus Mirabilis, some Klebsella Spland. Branhamella Catnrhalis, Shigella. Cephalexin also has the activity on most E.coli who have resisted ampicillin.

pharmacokinetics

cephalexin is completely absorbed through the gastrointestinal tract and reaches the peak concentration of plasma around 9 and 18mg/ml after 1 hour with the corresponding oral dose of 250 and 500mg, double the double dose reaches the double concentration. Drinking Cephalexin and food can slow down but the total amount of drugs absorb does not change. Up to 15% of the drug is associated with plasma proteins. The half -life of the drug in plasma is about 1 hour, increasing when the kidney function decreases.

cephalexin is widely distributed throughout the body but the amount in cerebrospinal fluid is negligible. Cephalexin passes the placenta and excreted breast milk with low concentrations.

Cephalexin is not metabolized. About 80% of the dosage excreted through urine in the form of unchanged in the first 6 hours via glomerular filtration and excretion in the renal tubules.

Before taking Cephalexin MKP 500 mekophar medicine for infection treatment (100 tablets)

How to use

Take oral use.

Dosage

According to the doctor's instructions.

Common dose

Adults: take 1-2 capsules/time, 3-4 times.

Children: Drink 25 - 50 mg/kg/day, divide 3-4 times.

normal treatment time from 7 to 10 days.

Adjust the dose when there is renal failure (creatinine clearance Creatinine clearance (ml/pH) Dosage (Mg) How to use 12 hours/time less than 5 250 from 12 - 24 hours/time Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when using overdose?

Handling

Protect the respiratory tract of patients, support ventilation and infusion, drink activated carbon many times. When the poisoning is overdose, there is no need to wash the stomach, unless it is taken by Cephalexin 5-10 times the normal dose. Dialysis can help eliminate drugs from blood, but often do not need.

If the overdose occurs, it is recommended to go to the nearest medical facility for medical staff to have treatment methods.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Cephalexin 500mg Mekophar 100V, you may experience unwanted effects (ADR).

Common

Digestive: diarrhea, nausea.

Less

Blood: Eosin hypernagus.

skin: rash, urticaria, itching. liver: Increased liver transaminase recovery.

Rare

Systemic: headache, dizziness, anaphylactic reaction, fatigue.

blood: neutrophils, platelets.

digestive: abdominal pain, fake colitis.

liver: hepatitis, jaundice.

Skin: Steven syndrome - Johnson, Diverse roses, poisoned epidermal necrosis, Quincke edema.

Urinary, genital: Itchy genitals, vaginitis, interstitial nephritis.

Instructions on how to handle ADR

Notify the doctor with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

cephalexin 500mg Mekophar 100V drugs in the following cases:

Patients with a history of allergies to antibiotics of cephalosporin.

Patients with a history of anaphylaxis caused by penicillin or other serious reactions through IgE immun globulin intermediaries.

Be cautious when using

cephalexin is often well tolerated even people who are allergic to penicillin, but there are also very few cross -allergens.

Use of long -term cephalexin can cause excessive growth of uncertainty bacteria (such as Candida, Enterococcus, Clostridium difficile) in this case should stop the drug. There has been a notice of fake colitis when using broad spectrum antibiotics, so it is necessary to pay attention to the diagnosis of this disease in patients with severe diarrhea during or after antibiotic use.

Similarly with antibiotics eliminated mainly through the kidneys, when renal failure, the dose of cephalexin must be reduced.

In patients using Cephalexin may have a false positive reaction when testing the urinary glucose by the "Benedict" method, fehling solution, or "clinitest", but with enzyme tests, it does not affect.

Cephalexin announcement causes positive positive Coombs.

cephalexin can affect the quantification of creatinine with alkaline picrat, giving artificial high results. However, the increase does not seem clinical significance.

The ability to drive and operate machinery

has not seen the drug that affects the ability to drive and operate the machine.

Pregnancy

Experimental research and clinical experience have not shown signs of toxicity for pregnancy and teratogenic. However, due to the lack of adequate research and strict control of the use of cephalexin for pregnant women, this drug must be used carefully and only for pregnant women when really necessary.

Breastfeeding period

cephalexin is excreted into breast milk. The drug reaches a maximum concentration of 4mcg/ml, then gradually decreases and disappears after 8 hours of taking the drug. Be careful when using cephalexin for breastfeeding women.

Medicinal interaction

because cephalosporin antibiotics such as cephalexin only act on proliferative bacteria, should not combine them with bactericidal antibiotics.

When combined with strong diuretics (Ethacrynic Acid, Furosemide) or antibiotics with kidney toxicity (aminoglycoside, polymyxin, colistin), cephalexin may cause more kidney toxicity.

Probenecid increases serum concentration and semi -waste time of cephalexin.

As other broad -spectrum antibiotics, cephalexin reduces the effects of contraceptives containing estrogen.

Storage

In a dry place, the temperature does not exceed 300C. Avoid light.

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