Cetampir Plus 400mg/25mg Savipharm Treatment of cerebral disorders, epilepsy, memory loss (3 blisters x 10 tablets)

Effects on platelets: In open studies in healthy volunteers and in patients with Raynaud's syndrome, increasing the dose of piracetam to 12 g is associated with reducing platelet function depending on the dose depends on the values ​​before treatment (platelet collection tests caused by ADP, Collagen, EPINPHRIN and release βTG) In these studies, Piracetam extends the bleeding time.

Effects on blood vessels: In animal studies, piracetam inhibits vasoconstriction and loses the effect of many different types of vasoconstriction. Piracetam has no vasodilation effect and does not create a phenomenon of "steal" ("steal" phenomenon), has no effect on slowing blood or flowing upstream or hypotension.

cinnarizin

cinnarizin is a derivative of piperaazine with antihistamine effect (H1).

cinnarizin is also a calcium antagonist. The drug inhibits blood vessel muscle contraction by blocking calcium channels. In some countries, cinnarizin is widely prescribed as a brain vasodilator to treat chronic brain vascular disease with the main indication of cerebral artery fiber; But random clinical trials about cinnarizin did not come to the conclusion clearly. Cinnarizin has been used in the treatment of Raynaud's syndrome, but it is not determined to be effective.

cinnarizin is also used in vestibular disorders.

pharmacokinetics

piracetam

Piracetam used by oral is absorbed quickly and almost entirely in the digestive tract. Biology nearly 100%. Peak concentration in plasma (40 - 60 micrograms/ml) appears 30 minutes after taking a dose of 2 g. The peak concentration in the cerebrospinal fluid is achieved after taking the drug 2 - 8 hours. Absorption of drugs does not change when long -term treatment.

The distribution volume is about 0.6 liters/kg. Piracetam absorbed into all tissues and can pass through the bloody brain barrier, placenta and even the membranes used in the renal roses. The drug has high concentrations in the cerebral cortex, frontal lobe, lobe and occipital lobes, cerebellum and base nuclei. Half life in plasma is 4 - 5 hours; Half life in cerebrospinal fluid is about 6 - 8 hours.

Piracetam is not attached to plasma proteins and is excreted through the kidneys in the form of intact. Piracetam clearance coefficient of the kidney in normal people is 86 ml/min. 30 hours after drinking, more than 95% of the drug is discharged in urine. If there is kidney failure, half -lifetime elimination increases. In patients with complete renal failure and not recovering, this time is 48 - 50 hours.

cinnarizin

After drinking, cinnarizin achieved plasma peaks from 2 to 4 hours. After 72 hours, the drug still eliminates urine in the form of metabolic. Half life of the drug is about 3-6 hours. Cinnarizin eliminated through fertilizer is the main form of unchanged and urine mainly in the form of metabolism.

Uncommon, 1/1000

Patients with liver failure.

Be cautious when using

notify the doctor before taking the drug if:

The drug can cause epigastric pain. Should take medicine after meals to reduce stomach irritation.

The drug can cause chicken sleep, especially at the beginning of treatment. Must avoid jobs that need alertness (for example: Driving).

Avoid long -term use in the elderly, because it can cause increased or appearing foreign symptoms, depression.

Lactose -containing drug ingredients. Patients with rare genetic problems such as galactose intolerance, lactase deficiency or Glucose - Galactose absorption disorders should not be taken.

Ponaceau 4R Lake color excipients in the drug component can cause allergic reactions. It is necessary to stop using the drug when an allergic reaction occurs.

The ability to drive and operate machinery

The drug has side effects that cause sleep, especially at the beginning of the treatment, so it is necessary to avoid the work that needs alertness (for example, driving, operating machinery).

Pregnancy

Do not use drugs for pregnant people.

Breastfeeding period

Not used for nursing mothers.

Drug interaction

When used simultaneously, combining Piracetam and Cinnarizin can increase the sedative effect of central kidney inhibitors, three -ring antidepressants and alcohol. Combining piracetam and cinnarizin also increases the effects of neurological and antihypertensive drugs. The effectiveness of the drug is enhanced by vasodilators and decreased by anti -pressure drugs.

Piracetam: It is still possible to continue the classic treatment of alcoholic (vitamins and sedatives) in case the patient has a vitamin deficiency or a strong agitation.

There has been a case of interaction between piracetam and thyroid essence when used simultaneously: confusion, stimulation and sleep disorders.

In a patient, prothrombin time has been stabilized by warfarin when used with piracetam.

cinnarizin: Alcohol (central nervous system inhibitors), three -round antidepressants: simultaneously used with cinnarizin can increase the sedative effect of each of the above drugs or cinnarizin.