Cetasone 0.5mg Pharbaco medicine for rheumatism, glue system disease (100 tablets)

Dosage form Box of 100 capsules
Specifications Betamethasone
Ingredient Allergic rhinitis, bronchial asthma, rheumatoid arthritis

Ingredient

Composition information	Content
Betamethasone	0.5mg

Uses

indications

Cetasone drugs are indicated in the following cases:

Treatment in many diseases such as rheumatism, glue system disease, allergies, skin diseases, hormonal diseases, face diseases, respiratory, blood, cancer and many other diseases that respond to corticosteroid therapy.

Systemic system diseases: Lupus erythematosus, systemic erythematosus, sclerosis, dermatitis Convex, Lupus skin form, diverse erythematosus (Stevens-Johnson syndrome), Peeling dermatitis, contact dermatitis Such as: allergic conjunctivitis, matte inflammation, posterior membranes and pervasive veins, optic neuritis.

Gastrointestinal diseases: Autoimmune chronic hepatitis, colon diseases, Crohn's progression and bleeding colon ulcer. Pharmacology

No report.

Dynamic pharmacokinetics

absorption: Betamethason is easy to be absorbed through the gastrointestinal tract.

Distribution: Quickly distributed into all tissues in the body, through the placenta and can be exported to breast milk in small amounts. During the circulation, Betamethason is mainly linked to globulin, with little albumin. Betamethason ratio is linked to blood protein about 60%, lower than hydrocortison.

Metabolism: The drug is metabolized mainly in the liver and excreted mainly through the kidney with a metabolic rate of less than 5%. Betamethason is a glucocorticoid. Prolonged effects with waste selling time about 36 - 54 hours.

Before taking Cetasone 0.5mg Pharbaco medicine for rheumatism, glue system disease (100 tablets)

How to use

Ocean cetasone medicine.

Dosage

adults

Dosage depends on each type of disease, the severity of the disease and clinical response. The following regimens are commonly used by the dose instructions:

Short -term treatment: 2 - 3 mg/day for the first few days, then reduce the dose to 0.25 - 0.5 mg/day for 2 to 5 days depending on the response.

Rheumatoid arthritis: 0.5 - 2 mg/day. For maintenance treatment, the lowest dose is effective. In most cases: 1.5 - 5 mg/day for 1 to 3 weeks, then reduced to the minimum dosage.

Patients with mixed connective tissue or ulcerative colitis may need larger doses.

Children

Can use the dose proportional to adults (for example, 75% for children from 12 years old, 50% for children from 7 years old and 25% for children from 1 year old), but clinical factors must be based on weight.

Treatment for children should be limited to the smallest dose and the shortest time possible.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Symptoms:

Body effects due to the overdose of the acting betamethason include: Sodium and water holding effects, increased appetite, mobilizing calcium and phosphorus accompanied by osteoporosis, loss of nitrogen, hyperglycemia, reducing the effect of tissue regeneration, increasing sensory with bacterial infections, kidney injuries, increased renal active activity, mental disorders and nerves.

Treatment:

In case of an acute overdose, the treatment should be immediately treated by gastric vomiting and douching, which should be monitored with serum and urine electrolyte. Pay special attention to sodium and potassium balance.

In case of chronic poisoning, the drug must be stopped slowly. Treatment of electrolyte imbalance if needed.

What to do when you forget 1 dose?

Side Effects

When using Cetasone you may experience unwanted effects (ADR).

Common, ADR> 1/100

Metabolism: loss of potassium, sodium hold, water retention.

Endocrine: Menstrual menstrual period, Cushing syndrome, inhibiting fetal growth in the uterus and children, reducing glucose tolerance, revealing potential diabetes, increasing insulin demand or hypoglycemic drugs in diabetes.

muscle muscle: muscle weakness, loss of muscle mass, osteoporosis, skin atrophy and under the skin, aseptic abscess.

Uncommon, 1/1000

Mental: refreshing, mood change, severe depression, insomnia.

eyes: glaucoma, opaque glass.

digestive: stomach ulcers and then may be punctured and bleeding, pancreatitis, abdominal distention, esophageal ulcer.

rare, ADR

Evaluation: Allergic dermatitis, urticaria, edema.

nervous: Hurry increased intracranial pressure.

Instructions on how to handle ADR

Most of the unwanted effects can recover or minimize by reducing the dose, this is a more preferred way to stop the drug.

Used with food that limits indigestion or gastrointestinal irritation may occur.

When prolonged treatment with betamethasone at the treatment dose may have to limit the use of sodium and supplement potassium, increase the diet of protein during prolonged treatment.

Using calcium and vitamin D can reduce the risk of osteoporosis caused by betamethasone during prolonged treatment.

People with a history or risk factor for stomach ulcers must take anti -ulcer drugs. Patients who are using glucocorticoids that have anemia need to think of the causes may be due to stomach bleeding.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Cetasone drugs contraindicated in the following cases:

Hypersensitivity to betamethason or with other corticosteroids, or with any component of Cetasone.

People with diabetes, mental illness.

Patients with systemic fungal infections, patients with bacterial infections and viral infections.

Be cautious when using

The lowest possible use can be controlled to control the treatment; When reducing the dose must gradually decrease step by step to avoid the risk of acute adrenal failure.

Due to the immunosuppressive effect, the use of betamethason at a higher doses than the necessary dose for physiological replacement therapy often increases the easily perceived sensation for infections. Therefore, in case of acute bacterial infections without appropriate antibiotics, there is no specification to use betamethasone. Betamethasone can cover symptoms of bacterial infections that make it difficult for diagnosis and treatment.

It is necessary to be very cautious in the following cases: congestive heart failure, new myocardial infarction, hypertension, diabetes, epilepsy, glaucoma, thyroid defect, liver failure, osteoporosis, stomach ulcers, mental disorders and kidney failure.

When using betamethason for children and the elderly, it is easy to increase the risk of some unwanted effects, in addition Betamethason can cause growth in children.

Cases of not being recommended: Patients with tuberculosis progress or suspected tuberculosis must not use betamethason except rare cases used to supplement treatment with anti -tuberculosis drugs.

Metal response when using systemic sugar corticosteroids should increase the risk of chickenpox, and maybe also infected with severe zoster herpes, so patients must avoid exposure to these diseases.

In case the patient does not have immune response but exposed to chickenpox or measles should be passive immunity.

Do not use living vaccines for patients who are using high -dose high -dose corticosteroid therapy for at least 3 months later. Although it is possible to use dead vaccines or detoxifying, although response can decrease.

During the long -term betamethasone treatment, the patient must be monitored gently, it is necessary to reduce sodium and add calcium and potassium.The prolonged betamethasone uses can cause chisel (especially in children), heavy glocom causes damage to the optic nerve.

The ability to drive and operate machinery

does not affect.

Pregnancy

betamethason can be easily through the placenta, using corticosteroids for pregnant animals that can affect the development of the fetus such as cleft palate, developmental retardation in the same muscle, affecting brain growth and development.

does not increase the rate of birth defects such as cleft palate, lips in humans. However, if used for a long time, repeated during pregnancy, corticosteroids may increase the risk of developmental retardation in the uterus, adrenal insufficiency may occur in newborns exposed to corticosteroids.

Use betamethason during pregnancy or people who are likely to consider the benefits and risks of the drug for the mother and embryo or fetus. However, if it is necessary to use corticosteroids, pregnant patients can still use.

Breastfeeding period

Considering the possibility of harming children because of milk excretion.

Drug interaction

paracetamol: betamethasone senses liver enzymes, which can increase to form a metabolic substance of toxic paracetamol to the liver. Therefore, an increased risk of liver toxicity if betamethasone is used with high doses of paracetamol.

3 -round antidepressants: These drugs do not reduce and may increase mental disorders caused by betamethasone, do not use antidepressants to treat adverse effects.

Oral and insulin anti -diabetes: Betamethasone can cause hyperglycemia, so it is necessary to adjust the dose of hypoglycemic drugs after stopping the betamethasone therapy.

glycosid digitalis: simultaneously used with betamethasone may increase the possibility of arrhythmia or toxicity of digitalis and hypotension.

Phenobarbiton, phenytoin, rifampicin or ephedrin: can increase the metabolism of betamethasone and reduce the treatment effect.

Coumarin anticoagulants when used simultaneously with betamethasone may increase or decrease anticoagulant effect, so it may be necessary to adjust the dose.

Increase or increase the severity of the gastrointestinal ulcer; Betamethasone may increase the concentration of salicylate in the blood; Must be important when using aspirin with betamethasone in the case of reducing prothrombin.

Steroids can reduce the effects of cholinesterase anti -choliniseras in myasthenia gravis, contrast in the gallbladder and the effect of nonsteroidal anti -inflammatory drugs.

Increased risk of hypokalemia in the blood when using simultaneously with theophylllin, carbenoxolon and antifungal drugs such as amphotericin B. Increasing toxicity may occur if hypokalemia occurs in patients taking cardiac glycosides.

Ritonavir and oral contraceptives can increase plasma concentrations. The effect of corticosteroids may be reduced in 3-4 days after using Mifepriston.

Somatropin's growth efficiency can be inhibited by corticosteroids.

corticosteroids can increase the metabolism of tretinoin, reducing the concentration of tretinoin.

Storage

less than 30 ° C, dry place, avoid light.

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