Ceteco Capelo 200 TW3 Treatment of low inflammatory inflammation (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Celecoxib
Ingredient Dysmenorrhea, joint spondylitis, arthritis, rheumatoid arthritis, adolescent arthritis, osteoarthritis

Ingredient

Composition information	Content
Celecoxib	200mg

Uses

Indications

Cetecocapelo 200 drugs are indicated in the following cases:

Treatment of rheumatoid arthritis symptoms in adults.

Pharmacy

Celecoxib is one of the nonsteroidal anti-inflammatory drugs, selective inhibition of cyclooxygenase-2 (COX-2), which has anti-inflammatory, analgesic, fever-reducing effect. The mechanism of action of Celecoxib is considered to inhibit the synthesis of prostaglandin, mainly through the Feoenzyme Cycloxygenase-2 (COX-2) effect, resulting in a reduction in the formation of prostaglandin.

Different from the majority of nonsteroidal anti-inflammatory drugs before, Celecoxib does not inhibit isenzyme cyclooxygenase 1 (COX-1) with human treatment concentrations. Cox-1 is a structural enzyme found in most tissues, large and platelets. COX-1 participates in thrombosis (such as thrombocytopenia to stop training) to maintain the fence of the mucosa/protection of the stomach and renal function (such as maintaining kidney perfusion). Due to the non-inhibition of COX-1, Celecoxib is less likely to cause side effects on the digestive tract but can cause side effects similar to non-selective nonsteroidal anti-inflammatory drugs.

pharmacokinetic

absorption

Celecoxib is quickly absorbed through the gastrointestinal tract. When taking Celecoxib with food-rich foods, the time to reach the plasma peak time is about 1-2 hours slower, the area under the absorption curve (AUC) increases by 10-20%.

When taking Celecoxib with aluminum acid neutralization medications and Magnesi reduces the plasma concentration of Celecoxib, 37% cmax and 10% decrease in AUC. Celecoxib can be used at a dose of 200 mg 3 times daily without paying attention to meal time, but at a dose of 400 mg 3 times daily need to be used with food to increase absorption.

The peak concentration of the plasma is usually reached at 3 hours after taking a single dose of 200 mg at hunger and averages 705 nanogam/ml. The concentration of drugs in a stable state in plasma is achieved within 5 days, there is no accumulation. In the elderly over 65 years old, the peak concentration in plasma and AUC increased by 40 and 50% respectively; Compared to young people, Celecoxib's AUC in a stable state increases 40 or 180% in mild or medium, corresponding liver failure people, and 40% decrease in chronic kidney failure (35-60 ml/minute glomerular filtration speed) compared to normal people.

Distribution

The distribution of the stable state is about 400 liters (about 7.14 liters/kg), so the drug is highly distributed into the tissue. At plasma treatment concentration, 97% Celecoxib is attached to plasma proteins.

Metabolism

Celecoxib is metabolized in the liver into non -active metabolites by isenzyme CYP45O2C9.

Elimination

Half of the lifetime eliminates plasma of Celecoxib after drinking is 11 hours and the clearance coefficient in plasma is about 500 ml/min. Half -life elimination of the drug persists in people with renal failure or liver failure. Celecoxib eliminates about 27% in urine and 57% in feces, less than 3% of the doses are eliminated unchanged.

Before taking Ceteco Capelo 200 TW3 Treatment of low inflammatory inflammation (10 blisters x 10 tablets)

How to use

Take oral medication once a day or divided into two equal times, all have the same effect in the treatment of bone - joint degeneration.

For rheumatoid arthritis, the dose should be divided into twice (200 mg/time, drink twice a day), can be taken without paying attention to the meal; Higher doses (400mg/time, 2 times a day) must be taken at meals to improve absorption.

Dosage

osteoarthritis: Normal dose: 200 mg/day oral or divided into 2 equal doses. Higher dose: 200 mg/day (such as 200 mg/l, 2 times a day).

Rheumatoid joints in adults: Normal dose: 100-200 mg/time, taken 2 times a day. Higher dose: 400 mg x 2 times/day.

Dai - Rectal Polyps: 400 mg/time, taken 2 times a day.

Pain in general and economic system:

Common doses used in adults: 400 mg oral 1 time, followed by 200 mg if needed, on the first day of pain relief, may give a dose of 200 mg more oral 2 times, if necessary.

Elderly: over 65 years: No dose adjustment, although the concentration of drugs soluble in plasma. For the elderly weighing less than 50kg, the lowest recommended dose must be used when treatment.

Hepatic failure: Not researched, not used for people with severe liver failure.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? The gastrointestinal bleeding also occurs. The more rare manifestations are hypertension, acute renal failure, respiratory inhibition and coma. Anaphylactic reactions have been informed with non -steroid anti -inflammatory drugs and may occur during an overdose.

Treatment: In 4 hours after overdose, vomiting therapy and/or active carbon (60-100g for adults, or 1-2 g/kg for children), and/or an osmotic bleach may be useful for patients with pathological manifestations or have too large amounts of drugs.

What to do when forgetting 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Cetecocapelo 200, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Digestive: abdominal pain, diarrhea, indigestion, flatulence, nausea.

Respiratory: Sore throat, rhinitis, sinusitis, upper respiratory infection.

Central nervous system: Insomnia, dizziness, headache.

Skin: rash.

general: back pain, peripheral edema.

Uncommon, 1/1000

No information.

Rare, 1/10000

Vascular love: fainting, congestive heart failure, ventricular vibration, pulmonary disease, vasculitis, stroke, peripheral mail, thrombosis.

digestive: intestinal obstruction, intestinal perforation, gastrointestinal bleeding, bleeding colitis, esophagus, pancreatitis.

liver: gallstones, hepatitis, jaundice, liver failure. Hematology: reducing platelet amount, loss of granulocytes, non -regenerated anemia, leukemia, reducing all blood cells ...

Metabolism: Hemorrhage reduction.

Central nervous system: loss of air conditioning, paranoia ...

kidney: Acute renal failure, interstitial nephritis. skin: Diverse erythema, hair dermatitis, Stevens-Johnson syndrome. general: infection, anaphylactic reaction, angioedema.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Cetecocapelo 200 drugs contraindicated in the following cases:

Severe heart failure. Severe renal failure (Creatinin rod coefficient

severe liver failure.

Sensitive people with Celecoxib, sulfonamid.

Inflammation (Crohn's disease, duodenal ulcer).

History of asthma, urticaria, or other allergic reactions after taking aspirin or other non -steroid anti -inflammatory drugs.

Precautions when used

Patients with a history of peptic ulcer, either gastrointestinal bleeding, although the drug is considered to cause less gastrointestinal disaster due to the selective Cox-2 inhibition.

Be careful when using Celecoxib for people with a history of asthma, allergies when taking aspirin or some nonsteroidal anti -inflammatory drugs because it can cause anaphylaxis.

Carefully use Celecoxib for the elderly, weakened because it is easy to cause gastrointestinal bleeding and often the renal function is impaired due to age.

Celecoxib can be toxic to the kidneys, especially when maintaining the blood flow through the kidneys, it requires the support of the kidney prostaglandin. Therefore, people with heart failure, kidney failure, or liver failure must pay attention when taking this drug.

Celecoxib has no intrinsic activity of platelet resistance and thus protects complications due to myocardial ischemia, especially for prolonged high doses (400 - 800 mg/ day).

Be cautious when using Celecoxib for people with foreign cell loss, people with edema and water.

The ability to drive and operate machinery

Because the drug can cause dizziness and headache when used, so be careful when driving and operating machinery.

Pregnancy

so far there has not been a complete study of Celecoxib in pregnant women. Medication should only be used for pregnant women when the benefits are higher than the risk that may occur for the fetus. Do not use Celecoxib in the last 3 months of pregnancy, because prostaglandin inhibitors may have a bad effect on the cardiovascular system of the fetus.

Breastfeeding period

whether Celecoxib is unknown whether it is distributed into breast milk or not. Because Celecoxib may have serious unwanted effects in breastfed children, consider gums/harms or stop breastfeeding, or stop using Celecoxib.

Drug interaction

simultaneous use of Celecoxib with Aspirin or other NSAIDs (ibuprofen, Naproxen, ...) can increase the risk of gastric ulcer.

fluconazole (diflucan) increases the level of celecoxib in the body due to the inhibition of celecoxib in the liver. Therefore, on patients using fluconazole, should start celecoxib treatment at the lowest recommended dose.

The drug increases 17% of the lithium concentration (Eskalith) in the blood. Therefore, closely monitoring lithium therapy during and after treatment.

Those who drink on three glasses/day may increase the risk of stomach ulcers when using NSAID, and this is also true for Celecoxib.

warfarin: Bleeding complications combined with increased prothrombin time occurred in some patients when using Celecoxib simultaneously with warfarin, so it is necessary to closely monitor tests on coagulation during and after treatment.

Storage

The temperature does not exceed 30 ° C, a cool dry place to avoid direct light.

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