Ceteco Prednisolon 5GG TW3 anti -inflammatory, anti -allergic drug (30 packs x 1.5g)

Dosage form Box of 30 packs x 1.5g
Specifications Prednisolone
Ingredient Vasculitis, hemolytic anemia, erythema lupus, bronchial asthma, colon ulcer, lymphoma, sarcoid, breast cancer, prostate cancer, rheumatoid arthritis, granules

Ingredient

Composition information	Content
Prednisolone	5mg

Uses

indications

Ceteco Prednisolon 5 mg drug is indicated in the following cases:

When the anti -inflammatory and immunosuppressive effect is needed. Literature of the lines in the final stage. Prednisolon only has weak mineralocorticoid effects. Anti -inflammatory effects of Prednisolon compared to other glucocorticoids: 5 mg of Prednisolon is valid equal to 4 mg of methylprednisolon and equal to 20 mg of hydrocortison.

Prednisolon inhibits the phenomenon of leukemia and infection into contaminated tissue, inhibits the function of lymphocytes and tissue macrophages.

The effect of Prednisolon is particularly pronounced on the macrophages, limiting their ability to have macrophages, limiting the ability to kill microorganisms. In addition to the function of the white blood cells, Prednisolon also affects inflammatory response by reducing prostaglandin synthesis due to phospholipase inhibition A2.

Finally, Prednisolon reduces the appearance of cyclooxygenase in inflammatory cells, thus reducing the amount of enzyme to produce prostaglandin. The immunosuppressive effect of Prednisolon is largely due to the above effects. In low doses, Prednisolon has anti -inflammatory effects; With high doses, Prednisolon has immunosuppressive effects.

Pharmacokinetics

absorption

Oral bioavailability of Prednisolon is approximately 82%. Peak concentration in plasma is achieved from 1-2 hours after taking the drug.

Distribution

Prednisolon binds to protein about 90 - 95%. The distribution of the drug is 1.5 ± 0.2 l/kg.

Metabolism - Elimination

Prednisolon is metabolized in the liver. Its metabolic substances are in the form of sulfate esters and glucuronids are excreted into the urine. The clearance of Prednisolon is 8.7 ± 1.6 ml/min/kg. Prednisolon waste sale time is approximately 1.7 - 2.7 hours.

Before taking Ceteco Prednisolon 5GG TW3 anti -inflammatory, anti -allergic drug (30 packs x 1.5g)

How to use

Dosage depending on the condition and response of the patient. After achieving the desired response, it is necessary to gradually reduce the dose to the extent that it is still appropriate to maintain the appropriate clinical response. Must constantly monitor patients to adjust the dose when necessary.

Take medicine at meals, mix the powder with moderate amount of water. Do not take the drug for more than 7 days or as directed by the doctor, gradually reduce the dose before stopping the drug.

Dosage

Initial dose for adults: from 5 - 60 mg/day, divided into 2-4 times/day, depending on the disease to be treated.

Dosage for children: From 0.14 - 2 mg/kg/day, divided into 4 times/day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Symptoms

Manifestations of cushing, muscle weakness, osteoporosis; These manifestations only occur when using long -term glucocorticoids.

Handling

In these cases, it is necessary to consider to make the right decision to suspend or stop using Glucocorticoid.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Ceteco Prednisolon 5 mg, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Central nerve: insomnia, nerves are easily stimulated.

digestion: Increase appetite, indigestion. Skin: Skin.

Endocrine and metabolism: diabetes.

Neurosomal and bone: joint pain.

Eyes: cataracts, glaucoma.

Respiratory: Nosebleeds.

Uncommon, 1/1000

Central nerve: Dizziness, convulsions, mental disorders, fake brain, headache, mood changes, delirium, hallucinations, refreshments.

Cardiovascular: edema, hypertension. skin: acne, skin atrophy, bruising, hyperpigmentation.

Endocrine and metabolism: Cushing syndrome, pituitary inhibitor - adrenal, slow growth, glucose intolerance, reduced hypotension, metabolic alkaline infection, amenorrhea, sodium and water, hyperlem of blood glucose.

digestive: gastric ulcer - duodenum, esophagus, nausea, vomiting, bloating, pancreatitis.

Neurosurgery - Bone: muscle weakness, osteoporosis, fracture.

Body: Hypersensitivity reaction.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Ceteco Prednisolon 5 mg contraindicated in the following cases:

Severe infections, except for bacterial shock and meningitis.

People are sensitive to prednisolon.

Skin infections of viral, fungi or tuberculosis.

is using a living virus vaccine.

Caution when using

Use carefully for people with osteoporosis, newly connected people (intestines, blood vessels), mental disorders, stomach ulcers, duodenum ulcers, diabetes, hypertension, heart failure and growing children.

Due to the risk of unwanted effects, be cautious when using systemic corticosteroids for the elderly, must use Prednisolon at the lowest doses and in the shortest possible time.

Acute adrenal insufficiency may occur when stopping the drug suddenly after a long time of treatment or when stress.

When using high doses, it can affect the effect of vaccinations.

The ability to drive and operate machinery

does not cause harmful effects when driving and operating machinery.

Pregnancy

using long -term systemic corticosteroids for mothers can lead to weight loss in newborns. Using high doses of corticosteroids in the body of the mother can cause a small risk of adrenal product reduction in newborns. Therefore, when using corticosteroids for pregnant women, it is necessary to consider the benefits that can be achieved compared to the risks that may occur with mothers and children.

It is necessary to use corticosteroids for pregnant women with asthma because asthma is dangerous to cause an oxygen deficiency for the fetus. Using glucocorticoid before birth also promotes maturity of the child's lungs, preventing symptoms of respiratory decline.

The period of breastfeeding

Prednisolon secretes breast milk with less than 1% of the dose and may not be clinically significant. However, it should still be careful when using Prednisolon in breastfeeding women.

Drug interaction

Prednisolon is a cytochrome P450 enzyme induction and is the substrate of the P450 CYP3A enzyme. Therefore, this drug has an impact on the metabolism of cyclosporin, erythromycin, phenobarbital, phenytoin, carbamazepin, ketoconazole, rifampicin.

Phenytoin, Phenobarbital, Rifampicin and diuretics decreased blood potassium may reduce the effect of prednisolon.

Prednisolon may increase blood glucose, so the insulin dose is higher than in combination.

Avoid simultaneous use of prednisolon with nonsteroidal anti -inflammatory drugs (NSAID) because it can cause stomach ulcers.

Storage

temperature below 30 ° C, cool dry place, avoid direct light.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.