Cetirizin 10mg Domesco medicine for allergic rhinitis, urticaria (10 blisters x 10 tablets)

Dosage form Film bag tablets
Specifications Box of 10 blisters x 10 tablets
Ingredient Cetirizin dihydrochlorid

Ingredient

Composition information	Content
Cetirizin dihydrochlorid	10mg

Uses

indications

Cetirizin 10mg Domesco drugs are indicated in the following cases:

Persistent allergic rhinitis, seasonal allergic rhinitis in adults and children over 12 years old. reason. Cetirizine has a selective antagonistic effect in H1 receptor, but almost no effect on other receptors, so there is almost no antagonistic effect acetylcholine and no serotonin antagonistic effect.

Cetirizine inhibits the early stage of allergic reactions through histamine intermediaries and also reduces the relocation of inflammatory cells and reduces the release of intermediate substances at the late stage of the allergic reaction.

Pharmacokinetics

absorption

The drug is absorbed quickly after drinking. The peak concentration is at equilibrium at 0.3 µg/ml, achieved after 1.0 ± 0.5 hours. Oral use changes when taking the drug with food.

Distribution

Expression distribution volume is 0.5 l/kg. The associated ratio with plasma protein is 90 - 96%. The drug in breast milk, but almost does not go through the barrier of blood - brain.

Metabolism

The drug is not first metabolized through the liver.

Era:

About 2/3 of the dose is exported in the form of unchanged urine. Selling plasma waste time is about 10 hours.

Cetirizin has a linear dynamic at the dose of 5 - 60 mg.

pharmacokinetics in special subjects

kidney failure

The pharmacokinetics of the same drug in healthy volunteers and patients with mild renal impairment (CLCR> 40 ml/minute). Patients with renal impairment level have just had a 3 times higher selling time and a 70% decrease in clearance compared to healthy volunteers.

Patients with hemorrhage (CLCR

Hepatic failure

Patients with chronic liver failure (liver cell failure, bile stasis and cirrhosis) use the 10 mg Cetirizine or 20 mg doses that increase the selling time of 50% and the clearance of 40% compared to healthy people. The dose adjustments need to be adjusted in patients with liver failure if there is simultaneous kidney failure.

Elderly

Use a 10 mg oral dosage, the selling time increased by about 50% and the clearance decreased by 40% in 16 older patients compared to young people. The decline in the clearance of cetirizine in older volunteers is associated with renal function impairment.

Children

The sale time of Cetirizine in children 6-12 years old is about 6 hours and in children 2-6 years old is 5 hours. In newborns and babies who are only 6 - 24 months old, the sale time is reduced to 3.1 hours.

Before taking Cetirizin 10mg Domesco medicine for allergic rhinitis, urticaria (10 blisters x 10 tablets)

How to use

Cetirizin 10mg drug used oral. Although food can reduce the peak concentration in the blood and extend the time to reach the peak concentration, it does not affect the level of blood absorption, so it can be taken with or outside the meal.

Dosage

Dosage: 10 mg x 1 time/day (1 tablet).

Elderly: There is no data proposal to reduce the dose in the elderly with normal kidney function.

Patients with average to severe renal failure: There is no data on effective/safety ratio in patients with renal impairment. Because cetirizine is excreted mainly through the kidneys, in case of irreversible treatment, the period of drug use must be based on individual kidney function.

Normal kidney function, CLCR ≥ 80 ml/minute: 10 mg x 1 time/day.

Mild kidney failure, Clcr 50 - 79 ml/minute: 10 mg x 1 time/day.

Average renal failure, Clcr 30 - 49 ml/minute: 5 mg x 1 time/day.

Severe renal failure, CLCR

Endenical renal failure or must be separated, CLCR

Patients with hepatic failure: need to adjust the dose in patients with liver failure if simultaneously kidney failure.

Children over 12 years: 10 mg x 1 time/day (1 tablet).

Children 6 - 12 years old: 5 mg x 2 times/day (half tablets 2 times/day).

Children under 6 years of age: Use other dosage forms to have the right dose.

In children with renal failure: Dosage should be adjusted depending on the patient based on the clearance of the kidney, age and weight of the patient.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? Up to now, there is no specific antidote.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Cetirizin 10mg Domesco, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Sleeping chicken (ratio causes depends on the dose).

fatigue, dry mouth, sore throat, dizziness, headache, nausea.

Uncommon, 1/1000

Anorexia or increased appetite, urinary retention, flushing, increasing salivation.

Rare, 1/10000

Anemia hemolysis, thrombocytopenia, severe hypotension, hepatitis, cholestasis, glomerulonephritis.

Very rare, ADR

Blood: platelets.

Immune: Anaphylaxis.

Mental: Scratching.

Neurological: taste disorders, muscle tone disorders, dysfunction, fainting, tremor.

Eyes: regulatory disorders, blurred vision, eye rotation.

Skin: edema.

Kidney and urinary: Urinary retention, bed beams.

Instructions on how to handle ADR

Stop using medicine and advise a doctor for timely medical assistance.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Cetirizin 10mg domesco drugs contraindicated in the following cases:

People with a history of allergies to Cetirizine, with hydroxyzine or any ingredients of the drug.

ending renal failure (CICR

Be cautious when using

need to adjust the dose in average or severe renal failure and people who are jurious kidney stool.

Need to adjust the dose in people with liver failure.

In some patients using Cetirizine have a chicken sleep, so be cautious when driving, or operating the machine, because it is easy to cause danger.

Avoid simultaneous use of Cetirizine with alcohol and central neurological inhibitors, because of the effect of these drugs.

The following patients need to be cautious when using Cetirizine:

Patients are at risk of increased urinary tract symptoms (for patients with risk factors for urinary retention: spinal lesions, prostate proliferation).

Patients with epilepsy or patients are at risk of seizures.

Skin allergic tests are limited by antihistamine drugs and need elimination time (3 days) before testing.

Caution for drugs containing lactose ingredients: Patients with genetic problems that do not use rare galactose, deficiency lapp lactase or glucose - galactose should not be used.

Patients with creatinine clearance 30 - 49 ml/min (medium renal failure) or

The ability to drive and operate machinery

Some patients using Cetirizine have chicken sleep, so do not use when driving and operating machinery.

Pregnancy

Although Cetirizine does not cause teratogenicity in animals, there is no adequate studies on pregnant women, so the drug should not be used during pregnancy.

The period of breastfeeding

cetirizine is excreted in milk, so nursing women should not use.

Interactive drug

so far has not seen significant interaction with other drugs. Cetirizine clearance decreases slightly when taken with 400 mg of theophyllline.

Storage

Store in a dry place, avoid light, temperature below 30 ° C.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.