Cetirizin 10mg drugs become a male treatment of allergic rhinitis, urticaria (10 blisters x 10 tablets)

Dosage form Film bag tablets
Specifications Box of 10 blisters x 10 tablets
Ingredient Cetirizin
Indication Rhinitis, allergic rhinitis, urticaria, itching

Ingredient

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Composition information	Content
Cetirizin	10mg

Uses

Indications

Cetirizin 10mg drug is indicated for adults and children over 12 years in the following cases:

Reduce the symptoms of nose and eyes of allergic and year -round allergic rhinitis. In vitro studies show that there is no effect on other H1 receptors. In addition to the anti -H1 Cetirizin effect, it also has an anti -allergy effect on a dose of 10 mg, 1-2 times/day, Cetirizin inhibits the late phase selection of eosin leukocytes, in the skin and conjunctiva of people with allergies.

Research in healthy volunteers shows that Cetirizin, at the dose of 5 and 10 mg, strongly inhibits swelling and red reactions caused by high concentration histamine into the skin, the effective correlation is not established.

Research on placebo control, cetirizin used at high doses of 60 mg daily in seven days, does not cause extension of QT.

In the recommended dose, Cetirizin has shown the improvement of the quality of life of patients with allergic and seasonal allergic rhinitis.

pharmacokinetic pharmacokinetics

The peak concentration is measured in equilibrium state of about 0.3 mcg/ml, achieved in about 1.0 ± 0.5 hours. Without the accumulation of cetirizin is observed for 10 days at a dose of 10 mg/day.

Cetirizin's absorption is not reduced by food, although the absorption rate decreases. Cetirizin, capsules, capsules or tablets are similar.

Expression distribution volume is 0.50 liters/kg. Linking with plasma proteins is 93+0.3%. Cetirizin does not change Warfarin's protein bonds.

Cetirizin does not undergo the first strong metabolism. About 2/3 of the dose is eliminated in urine in the form of constant. Selling plasma waste time is about 10 hours. Cetirizin has linear dynamics at a dose of 5 - 60 mg.

Elderly: After a single dose of 10 mg, the sale time increased by about 50% and the clearance decreased by 40% in 16 elderly people compared to normal people. The decrease in cetirizin clearance appears in these elderly volunteers related to their renal function impairment.

Children, newborns and newborn children know: The sale time of cetirizin is about 6 hours in children 6 - 12 years old and 5 hours in children 2-6 years old. In newborns and babies who are only 6 to 24 months old, reduced to 3.1 hours.

Patients with renal impairment: The pharmacokinetics of the drug are similar to patients with mild renal impairment (creatinine clearance is 40 ml/minute) compared to healthy volunteers. Patients with average renal failure have tripled the sale time and reduce 70% of the clearance compared to healthy volunteers.

Patients with hemolysis (creatinine clearance below 7 ml/min) giving a single dose of 10 mg of Cetirizin with 3 times the sale time and reducing 70% of the clearance compared to normal. Cetirizin is poorly filtered by hemons. The dose adjustment is needed in medium renal impairment. or heavy.

Patients with liver failure: Patients with chronic liver disease (of liver cells, bile stasis, and cholecyst cirrhosis) for a single dose of 10 or 20 mg of Cetirizin with 50% increase in the sale time and reduce 40% of the clearance compared to healthy people.

Adjusting the dose is only necessary in patients with liver failure if there is simultaneous kidney failure.

Before taking Cetirizin 10mg drugs become a male treatment of allergic rhinitis, urticaria (10 blisters x 10 tablets)

How to use

Cetirizin 10mg drug is used orally. Take medicine with water.

Dosage

Children under 12 years: Do not use because it is not suitable for this type of pill.

Adults and teenagers over 12 years: 10 mg (1 tablet) x 1 time/day.

Elderly: Data shows no need to reduce the dose in the elderly with normal kidney function.

Patients with medium to severe kidney failure: There is no data on the effectiveness/safety of patients with renal failure.

Adjust the Cetirizin 10mg dose for adults with impaired renal function.

Kidney function ClCR (ml/minute) Dosage x 1 time/day

medium renal failure 30 - 40 5 mg x 1 time/day 10 Contraindicated

Patients with liver failure: No dose adjustment in patients with only liver failure.

Patients with liver failure and kidney failure: The dose should be adjusted (see patients with medium to severe kidney failure).

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Symptoms

Observing symptoms after overdose of Cetirizin 10mg shows mainly related to the central nervous system (CNS) or antivolinergic effects. Side effects are reported after taking at least 5 times the recommended daily dose: Confusion, diarrhea, dizziness, fatigue, headache, discomfort, pupils, itching, restlessness, sedation, sleep, stunning, tachycardia, tremor and urinary retention.

Handling

There is no specific antidote. Symptomatic treatment or supportive treatment. Stomach lavage should be considered after drinking quickly detected. Or use activated carbon. Hemorrhage is not effective in treating overdose of Cetirizin.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Cetirizin 10mg, you may experience unwanted effects (ADR).

Uncommon, 1/1000

Mental: agitation.

Neurology: Perception.

Digestive: diarrhea.

Skin: itching, rash

Body: weakness, discomfort.

Rare, 1/10000

The immune system: hypersensitivity.

Mental: Causing aggression, confusion, depression, hallucinations, insomnia.

Neurology: convulsions.

Heart: tachycardia.

Mile liver: Abnormal liver function (increasing transaminase, alkaline phosphatase, gamma-value and bilirubin)

Skin: urticaria.

Systemic: edema, weight gain.

Very rape, ADR

Blood and lymph: platelets.

immune system: Anaphylaxis.

Mental: jerking machine.

Neurological: Dharma taste, fainting, tremor, muscle tone, dysfunction.

Eyes: Eye regulatory disorders, blurred vision, eye rotation.

Skin: Vascular nerve edema, fixed chromato.

Kidney and urinary: Difficult urinating, bedwetting.

unknown frequency

Metabolism and nutrition: Increase appetite.

Mental: The intention of death.

Neurology: Memory loss, memory impairment.

ears and maze: dizziness.

Kidney and urinary: Urinary retention.

Instructions on how to handle ADR

When experiencing side effects of Cetirizin 10mg, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Cetirizin 10mg contraindicated drug in the following cases:

People with a history of allergies to cetirizin, with hydroxyzine or any ingredients of the drug.

ending renal failure (CLCR

Caution should be used when used

Need to adjust the dose in people with liver failure.

In some people using Cetirizin, there is a phenomenon of chicken sleep, so be careful when driving or operating the machine, because it is easy to cause danger.

Avoid simultaneous use of cetirizin with alcohol and central neurological inhibitors, because of the effect of this drug.

Warning for lactose excipients: Patients with rare genetic disorders in tolerance Galactose, deficiency of all lactase or malposive glucose-galactose should not use this drug.

Ponaceau 4r color in the drug can cause an allergic reaction, so be cautious when taking this medication.

The ability to drive and operate machinery

The drug can cause dizziness, headache and sleep, thus avoiding for people who are driving and operating machinery.

Pregnancy

Although Cetirizin does not cause teratogenicity in animals, there is no complete studies on pregnant people, so the drug should not be used during pregnancy.

Breastfeeding period

Cetirizin 10mg secreted in milk, so avoid breastfeeding when the mother uses medication.

Drug interaction

Interaction

Avoid combining with central neurological inhibitors such as sedatives and alcohol.

The calmly reduced cetirizin clearance when taken with 400 mg of theophylin.

interact with pseudoephedrin.

Cavalry

Due to the absence of studies on the correlation of the drug, not mixing this drug with other drugs.

Storage

Store in a cool dry place, avoid light, temperatures below 30 ° C.

Other drugs

Disclaimer

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