Cetirizin 10mg Vidipha drugs treat allergic rhinitis, urticaria (10 blisters x 10 tablets)

Dosage form Film bag tablets
Specifications Box of 10 blisters x 10 tablets
Ingredient Cetirizin
Indication Rhinitis, allergic rhinitis, eczema, itching, contact dermatitis, stuffy nose

Ingredient

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Composition information	Content
Cetirizin	10mg

Uses

Indications

Use Cetirizin 10mg Vidipha is indicated in the following cases:

Treatment of persistent allergic rhinitis, seasonal allergic rhinitis, indefinite urticaria and allergic conjunctivitis.

Pharmacokology

Cetirizine is a derivative of piperazine and is a metabolic substance of hydroxyzine.

Cetirizine has a strong antagonistic and selective effect on peripheral H1 receptors, but almost no effect on other receptors, so there is almost no serotonin antagonistic effect. Cetirizine inhibits the early stage of allergic reactions through histamine intermediaries, reducing the relocation of inflammatory cells and reducing the release of intermediate substances at the late stage of allergic reactions.

The polarization of cetirizine increases compared to hydroxyzine, so the distribution of the drug into the central nervous system decreases and has less impact on the central nervous system compared to the first -generation antihistamine drugs (diphenhydramine, hydroxyzine) so it causes less drowsiness. However, the proportion of patients using Cetirizine has unwanted effects such as sleeping chicken is higher than patients using other second -generation antihistamine drugs such as Loratadine.

pharmacokinetics

absorption:

The drug is absorbed quickly after drinking. The peak concentration is at equilibrium at 0.3 mcg/ml, achieved after 1.0 ± 0.5 hours. Oral use changes when taking the drug with food.

Distribution:

Expression distribution volume is 0.5 l/kg. The associated ratio of plasma proteins is 93 ± 0.3%. Cetirizine does not change Warfarin's ability to bind plasma protein. The drug in breast milk but almost does not go through the blood barrier -N.

Metabolism:

The drug is not metabolized for the first time.

Era:

About 2/3 of the dose is exported in the form of unchanged urine. Selling time in plasma is about 10 hours. Cetirizine has linear dynamics at the dose of 5–60 mg.

Before taking Cetirizin 10mg Vidipha drugs treat allergic rhinitis, urticaria (10 blisters x 10 tablets)

How to use

Cetirizin 10mg drug used orally, oral before or after meals.

Dosage

Adults and children over 6 years old: 10 mg x 1 time/day.

Patients with liver failure: Dose need to be half reduced.

Patients with renal impairment: The dose is calibrated according to the CLCR as the following table:

Kidney function

ClCR (ml/minute)

Dosage x 1 time/day

average renal failure 30–49 5 mg x 1 time/day 10 Contraindicated Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when using overdose?

Serious overdose should cause vomiting and gastric lavage along with supportive methods. Hemorrhage is not effective in treating overdose of Cetirizine.

What to do when forgetting a dose? But if it's almost time for the next dose, only use the following dose. Do not use double dose or add dose to compensate for the dose to forget to drink.

Side Effects

When using Cetirizin 10mg Vidipha, you may experience unwanted effects (ADR).

Common, ADR> 1/100

No report.

Uncommon, 1/1000

Mental: agitation;

Neuroscope: Perseverance;

Digestive: diarrhea;

Skin and subcutaneous tissues: itching, skin rash;

Other disorders: weakness, discomfort.

Rare, 1/10000

immune: hypersensitivity;

Neurological: aggressive, confused, depressed, hallucinations, insomnia, convulsions, movement disorders;

Cardiovascular: tachycardia;

Mile liver: Abnormal liver function (increased transaminase, alkaline phosphatase, gamma-value and bilirubin);

Skin and subcutaneous tissues: urticaria;

Other: edema, weight gain.

Very rare, ADR

Blood and lymph: platelets;

Immune: Anaphylaxis;

Mental: Mechanical machine (tic);

Neurological: taste disorders, fainting, tremor, tone disorders, movement disorders.

Instructions on how to handle ADR

Stop using medicine and advise a doctor for timely medical assistance.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated:

Cetirizin 10mg Vidipha drugs are contraindicated in the following cases:

People with a history of allergies to Cetirizine, Hydroxyzine or any ingredients of the drug.

ending renal failure (CLCR

Be cautious when using

need to adjust the dose in average or severe renal failure and people who are jurious kidney stool.

Need to adjust the dose in people with liver failure.

Avoid simultaneous use of Cetirizine with alcohol and central neurological inhibitors because of the effect of these drugs.

Caution in patients with prostate hypertrophy, spinal cord lesions because Cetirizine may increase the risk of urinary retention.

Be careful to use Cetirizine for epilepsy patients and patients at risk of seizures.

Skin allergic test is inhibited by antihistamine and the time to eliminate the body from the body for a few days (3 days) is necessary before taking these tests.

Patients with galactose intolerance, lactase deficiency or glucose -galactose absorption disorders should not use this drug.

The drug contains the ingredient that can cause unwanted effects such as digestive disorders, diarrhea (castor oil), allergic reactions (ponaceau 4r).

Children under 6 years of age should use other preparations.

The ability to drive and operate machinery

should be cautious when driving or operating machinery due to drugs that can cause unwanted effects such as sleeping, fatigue, dizziness, headache.

Pregnancy

Although Cetirizine does not cause teratogenicity in animals, there is no adequate studies in pregnant women. Therefore, do not take the drug during pregnancy.

Breastfeeding period

Cetirizine excreted in milk, so do not breastfeed when the mother uses the medication.

Interactive drug

Avoid in combination with central neurological inhibitors such as sedation and alcohol.

Cetirizine clearance decreases slightly when taken with 400 mg of theophylline. Do not use slow release tablets combined with Cetirizine Hydrochloride and Pseudoephedrine Hydrochloride in patients who are taking or stopping Maoi.

Food does not affect the absorption level of Cetirizine, although the absorption rate decreases.

Storage

In a dry place, the temperature does not exceed 30 ° C, avoiding light.

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