Cetirizine 10 Stella drugs reduce symptoms of urticaria, allergic rhinitis (10 blisters x 10 tablets)

Cetirizine is a metabolic of Hydroxyzin in humans, a strong and selective antagonist on peripheral H1 receptors. In In vitro studies on the ability to connect with the receptor shows that the drug has no significant affinity with any receptors but the receptor H1.

Pharmaceutical effects: In addition to the H1 receptor resistance, Cetirizine also shows anti -allergic effects: with a dose of 10 mg x 1 time or twice a day, inhibitors inhibit the collection of eosinophilia in the late stage, especially in the skin and conjunctiva of allergens that are exposed to allergens.

Clinical efficiency and clinical safety: Studies in healthy volunteers show that Cetirizine at the dose of 5 and 10 mg significantly reduces urticaria and the erythema reactions caused by the high concentration of histamine on the skin, but the correlation between efficiency and safety has not been set.

In the recommended dose, Cetirizine shows the effect of improving the quality of life of patients with seasonal or year -round allergic rhinitis.

Children: In a 35 -day study in children from 5 to 12 years old, there is no tolerance to the antihistamine effect (blocking urticaria and erythema reaction) of Cetirizine. After the dose repeated Cetirizine, when stopped treatment, the skin recovered the normal reaction with histamine within 3 days.

pharmacokinetic

absorption

Plasma concentration in a stable state is about 300 ng/ml and achieved within 1.0*0.5 hours. The distribution of pharmacokinetic parameters such as plasma peak concentrations (CMAX) and area under the curve (AUC), the same in the original lover. Cetirizine's absorption level is not hesitated by food although the absorption speed decreases.

Distribution

The distribution of ants is 0.50 l/kg. Cetirizine cohesion to plasma protein is 93 ± 0.3%. Cetirizine does not change the protein cohesion of warfarin.

Metabolism

Cetirizine experienced negligible first metabolism.

Elimination

The last waste time of the drug is about 10 hours and there is no cetirizine accumulation after daily use of 10 mg for 10 days. About 2/3 of the doses are excreted in a constant urine.

Symptoms

The symptoms recorded after overdose of Cetirizine are mainly related to the effects on the central nervous system or antivolinergic effects.

Unwanted effects are recorded after using 5 times the recommended daily doses: confusion, diarrhea, dizziness, fatigue, headache, discomfort, copper dilatation, itching, restlessness, drowsiness, dreamy, stunned heart, fast -pounded heart, tremor and urinary retention.

Handling

There is no specific antidote for Cetirizine.

If the overdose occurs, patients need symptoms and support treatment. If you take the medicine in a short time, you can consider gastric lavage. Ineffective in the type of cetirizine from the body by hemorrhage.

What to do when you forget 1 dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

When experiencing side effects of Cetirizine 10, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Precautions when used

There is no clinical interaction with alcohol (for blood levels in 0.5 g/l) proved at the dose of treatment. However, be cautious when taking the drug simultaneously with alcohol.

Patients with congenital urinary factors (such as spinal cord lesions, hyperplasia) because Cetirizine may increase the risk of urinary retention.

Caution in epilepsy patients and patients at risk of seizures.

It is necessary to perform skin allergies before taking the drug due to this test that is inhibited by antihistamine and washing time (3 days).

Cetirizine Stella 10mg contains lactose. This drug should not be used for patients with rare genetic problems galactose intolerance, total lactase enzyme deficiency or poorly absorbed glucose-galactose.

The effect of the drug on driving and operating machinery

with the recommended dose of 10 mg, without any clinical manifestations related to the ability to drive and operate machinery. However, patients find that drowsiness should limit driving, participate in dangerous activities or operate machinery, patients should not overdose recommended and should monitor their response to the drug.

pregnancy and lactation

Pregnancy

Research on mice shows no direct or indirect harmful effects on pregnancy, the development of embryos and fetuses during birth or after birth. Be careful when prescribing pregnant women.

Breastfeeding period

Cetirizine can be breast milk with a concentration of 25% to 90% of the measured concentration in plasma, depending on the time of sampling after taking the drug. So be cautious when using cetirizine in nursing women.

fertility

very few research data on human fertility, safety has not been set.

Drug interaction

Drug interaction

Avoid combined with central neurological inhibitors such as sedatives and alcohol.

Cetirizine clearance decreases slightly when taken with 400 mg of theophyline.

Tyeum of drugs

Due to the absence of studies on the correlation of the drug, not mixing this drug with other drugs.