Cezirnate 250 mg Uphace treat mild infections to fit the respiratory tract (2 blisters x 5 tablets)

Dosage form Box of 2 blisters x 5 tablets
Specifications Cefuroxim
Ingredient Uphace

Ingredient

Composition information	Content
Cefuroxim	250mg

Uses

indications

Cezirnate 250 mg drug is indicated in the following cases:

Treatment of mild infections to fit the airways caused by sensitive bacteria:

otitis media, recurrent sinusitis, tonsillitis, recurrent pharyngitis, an outbreak of acute bronchitis with superinfection and infected pneumonia in the community.

Treatment of gonorrhea without complications and treatment of Lyme in the beginning during the erythema symptom caused by Borrelia Burgdorferi.

Pharmacology

cefuroxim is an oral, semi -synthetic cephalosporin antibiotic, 2nd generation. Cefuroxim has the effect of killing bacteria in the stage of growth and division by inhibiting synthesis

Like other 2nd generation cephalosporin antibiotics, cefuroxim has in vitro active activity in gram -negative bacteria better than the first -generation cephalosporin antibiotics, but the spectrum on the IAI gram -negative bacteria is narrower than the 3rd generation cephalosporin antibiotics. Cefamandol, therefore, has a better effect on bacterial strains that produce beta lactamase such as Haemophyllus Inffuenzae, Neisseria, Escherichia Coli, Entobacter, Klebsiella.

antibacterial spectrum:

Cefuroxim has an anti -Gram -positive and anaerobic resistance activity, including most staphylococcus strains of penicilinase, and gram -negative bacterial resistance. Cefuroxim has a high activity, so the minimum inhibitory concentration (mic) is low for strepfococcus strains (group A, B, 0 and G), gonococcus and meningoccus strains.

Initially, Cefuroxim also had low mic for gonococcus strains, Moraxella Catatrhalis, Haemophilus Influenzae and Klebsiella spp. Beta-lactamase secretion. But now, in Vietnam, many bacteria have been resistant to Cefuroxim, so the mic of the drug for these strains has changed. En

Clostridium difficile strains, Pseudomonas spp., Campylobacter spp., Acinetobacter calecoaceticus, Legionella spp. All are not sensitive to Cefuroxim. Staphylococcus aureus strains, Staphylococcus epidermidis resistant methicilin are resistant to cefuroxim. Listeria monocytogenes and most of the Enterococcus strains are also resistant to cefuroxim.

pharmacokinetics

absorption:

After drinking, Cefuroxim acetyl is absorbed through the digestive tract and is quickly hydrolyzed in the intestinal mucosa and in the blood to release Cefuroxim into the complete system. The drug is best absorbed when taken at meals.

Distribution:

About 33% to 50% of the amount of cefuroxim in the blood seams with plasma proteins. Cefuroxim is widely distributed to organizations and fluids in the body. The apparent distribution volume in healthy adults ranges from 9.3 - 15.8 liters/1.73 m2. A small amount of Cefuroxim can pass through the brain blood barrier in case the meninges are not inflamed. However, Cefuroxim only achieves the concentration of treatment in cerebrospinal fluid when intravenously in case of brain inflammation. The drug through the placenta and excreted through breast milk.

Metabolism:

Cefuroxim is not metabolized and is discharged in the form that does not change both according to the glomerular filtration mechanism and excreted in the renal tubules.

Era:

Half of the lifetime elimination of the drug in plasma is about 1-2 hours. The drug is high in urine. Cefuroxim only excreted in honey with a very small amount.

Before taking Cezirnate 250 mg Uphace treat mild infections to fit the respiratory tract (2 blisters x 5 tablets)

How to use

Take oral use, do not crush the pill. Take medicine at meals to increase bioavailability.

Dosage

Adults:

The respiratory infections caused by sensitive bacteria: take 1 or 2 tablets, every 12 hours. Treatment time 10 days.

The new Lyme disease: Take 2 tablets, 12 hours, in 20 days.

Inhabulating gonorrhea: The only dose of 4 tablets.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Symptoms:

Most drugs only cause nausea, vomiting and diarrhea. However, it can cause an increase in nervous stimulation and seizures, especially in people with kidney failure.

Management:

Protection of the respiratory tract for patients, ventilation support and infusion.

If developing convulsions, stop using the drug immediately; Anti -seizures may be used if clinically indicated. Hemorrhage can eliminate blood from the blood, but most of the treatment is supporting or resolving symptoms.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Cezirnate 250 mg, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Digestive: diarrhea.

Skin and subcutaneous tissue: lumpy skin.

Uncommon, 1/1000

General: Anaphylaxis, Candida infection.

Blood: Eosin hypernagus, leukopenia, neutropenia, positive cooom test. digestion: Nausea, vomiting.

Skin and subcutaneous tissue: urticaria, itching.

Rare, ADR

Digestive: fake colitis.

TKTW: convulsions, headaches, agitation;

muscle, bones, joints: joint pain;

Skin and subcutaneous tissue: Diverse roses, Steven - Johnson syndrome, poisoned epidermal necrosis;

Hypersensitivity: Fever; blood: Hemolytic anemia; liver: jaundice of cholestasis, increase AST, alt, alkaline phosphatase, LDH and air bilirubin concentration; kidney: Acute renal failure and interstitial nephritis, hyperurine hyperemia, increased blood creatinine, urinary tract infection, kidney pain, urethra or bleeding, difficulty urinating;

Infections: Vaginal inflammation, vaginal candidiasis, itching and vaginal irritation.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Cezirnate drug 250 mg is contraindicated in the following case:

Patients with a history of allergies to antibiotics of cephalosporin.

Be cautious when using

Caution for patients with a history of allergies with the beta-lactam group.

Be careful when giving patients simultaneously with strong diuretics, because it can have adverse effects on kidney function.

Should reduce the dose of cefuroxim injected in temporary or chronic kidney failure.

Long -term Cefuroxim can make unnecessary strains overexplicable. Need to follow the patient carefully. If the superinfection is serious during treatment, the drug must be stopped.

Should be very careful when prescribing broad -spectrum antibiotics for people with gastrointestinal diseases, especially colitis.

During the treatment process, if a seizure appears, it should be stopped and used appropriate epilepsy medications.

The ability to drive and operate machinery

has not recorded the effect of drugs on drivers and operating machinery.

During pregnancy

There is no control that fully assesses the safety of the drug on pregnant women and due to animal studies do not always predict the response of humans, so they only use this drug for pregnant women when really necessary.

Breastfeeding period

cefuroxim excreted in breast milk at low concentrations. The risk of unwanted effect on breastfeeding is not fully assessed, the ability to accumulate antibiotics in children is possible. Therefore, only use drugs for women who are breastfeeding after carefully consider the risk and benefits and must monitor children in the process of treating antibiotics for mothers.

Medicinal interaction

Probenecid is high doses, reducing the retention of Cefuroxim in the kidney, making the cefuroxim concentration higher and longer.

Cefuroxim simultaneously used with aminoglycosides or strong diuretics (such as Furosemid) may increase the toxicity of the kidneys.

Cefuroxim acetyl canal can affect the bacteria in the intestine, reducing estrogen reabsorption, thus reducing the effects of oral contraceptives containing estrogen and progesterone.

Ranitidin with sodium bicarbonate reduces the bioavailability of cefuroxim acetyl.

Should use Cefuroxim acetyl at least 2 hours after antacids or H2 blockers, as these drugs can increase the gastric pH.

Storage

In a dry place, avoid light, temperature not exceeding 30 ° C.

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