Cezirnate 500mg UPHACE medicine for infections (2 blisters x 10 tablets)

Dosage form Box of 2 blisters x 10 tablets
Specifications Cefuroxim
Ingredient Tonsillitis, sore throat, sinusitis, urinary tract infections, urethritis, skin and soft tissue infections, acute bronchitis, pneumonia, Lyme disease

Ingredient

Composition information	Content
Cefuroxim	500mg

Uses

indications

Cezirnate 500mg drug is indicated in cases of treatment of infection diseases including:

Acute tonsillitis caused by streptococcal and sore throat. The first period.

Cefuroxim inhibits the synthesis of bacterial cell walls after attaching to Pbps. This leads to bacterial peptidoglycan (peptidoglycan), causing bacterial cell walls to decompose and die.

Bacterial sensitivity level:

The anti -drug resistance ratio depends on geography and time and may be very high for certain species. Information about local drug resistance is very important, especially when treating serious infections.

In vitro sensitivity of bacteria with cefuroxim:

Sensitive bacteria:

Aerobic grams include: Staphylococcus aureus, Coagulase Negative Staphylococcus, Streptococcus pyogenes, Streptococcus agarcjctiae. Moraxella catrhalis.

Aerobic gram: Streptococcus pneumoniae. spp ..

Gram -positive anaerobic positive includes: peptostreptococcus spp., Propionibacterium spp.

Aerobic grams include: Enterococcus Faecalis, Enterococcus taecium.

anaerobic gram: bacteroides fragilis.

Other: Chlamydia spp.

After drinking, Cefuroxim acetyl is absorbed through the gastrointestinal tract and is quickly hydrolyzed in the intestinal mucosa and in the blood to release Cefuroxim into the circulatory round. The optimal absorption occurs when the drug is taken immediately after the meal.

Distribution:

Different protein bonds are from 33% to 50% depending on the method of drug use.

Metabolism:

Cefuroxim is not metabolized.

Serum selling time is about 1 to 1.5 hours. Cefuroxim is eliminated by glomerular filtration and excreted through the renal tubules. The clearance of the kidney is in the range of 125 -148 ml/min/1.73 m2).

Before taking Cezirnate 500mg UPHACE medicine for infections (2 blisters x 10 tablets)

How to use

Cezirnate 500mg pills in the form of oral film tablets, it is best to take after meals to achieve optimal absorption effect.

Do not chew or crush the tablet when taking, so it is not suitable for medication for patients who cannot swallow pills, children should use oral mixture.

Dosage

normal treatment time is 7 days (can range from 5 to 10 days).

Adults and children (> 40 kg):

Acute otitis media: 500 mg x 2 times/day.

Exacection of chronic bronchitis: 500 mg x 2 times/day.

Lyme disease: 500 mg x 2 times/day, treatment for 14 days (may fluctuate 10-21 days).

Patients with renal failure:

Creatinine clearance ≥ 30 ml/min/1.73 m2: No dose adjustment (125-500 mg x 2 times/day).

Creatinine clearance 10 - 29 ml/min/1.73 m2: The standard dose of each person every 24 hours.

Creatinine clearance

During hemolysis process: Add a standard dose of each person at the end of the stage of fertilization.

For patients with liver failure:

There is no information on the effects of drugs on patients with liver failure, because the drug is mainly eliminated by the kidneys, so the liver dysfunction may not affect the pharmacokinetics of the drug.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? Overdose symptoms may occur without a suitable dose in patients with renal failure.

Management: The concentration of Cefuroxim in serum may be reduced by blood decline or peritoneal fertilizer.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Cezirnate 500mg you may experience unwanted effects (ADR).

Common, ADR> 1/100:

Fungal infection and parasitic infection: Excessive development of candidiasis.

Bloody and lymphatic disorders: Nothing hypernagus.

Neurological disorders: headache, dizziness.

Liver system disorders: slightly increase mild enzymes

Disorders of the digestive system: diarrhea, nausea, abdominal pain.

Uncommon, 1/1000

Blood and lymphatic disorders: positive Coombs test, thrombocytopenia, leukopenia.

Disorders of the digestive system: vomiting.

Skin and subcutaneous tissue disorders: Dermatitis.

Unknown frequency:

Fungal infection and parasitic infection: Excessive growth of Clostridium Difficile infection.

Hemorrhagic and lymphatic disorders: Hematopoeia.

Immune system disorders: Drug fever, serum, anaphylaxis, Jarisch - Herxheimer reaction.

Disorders of the digestive system: fake colitis.

Hepatic liver disorders: jaundice, hepatitis.

Skin and subcutaneous tissue disorders: urticaria, itching, polymorphic erythematosus, Steven - Jonhson syndrome, poisoning epithelium, angioedema.

Instructions on how to handle ADR:

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Cezirnate 500mg contraindications in the following cases:

Hypersensitivity to Cefuroxim or any ingredients of the drug.

Patients with hypersensitivity to antibiotics of cephalosporin.

History of serious hypersensitivity (such as allergic reactions) with any other antibiotics (penicillin, monobactam, carbapenem).

Caution when using

Allergic reactions:

Similar to beta-lactam antibiotics, serious allergic reactions are sometimes reported.

In case of severe allergic reactions, medication should be discontinued and timely treatment must be taken.

Before taking cefuroxim acetyl, it is necessary to be careful for patients with a history of allergic reactions with penicillin or other beta-lactam.

Jarisch-Herzheimer reaction:

Has the Jarisch-Herzheimer reaction after taking Cefuroxim Acetil to treat Lyme disease.

It is a direct result from the bactericidal activity of Cefuroxim acetyl to the bacteria causing Lyme disease, which is Borrelia Burgdorferi.

Should let patients know that this reaction is common due to the treatment of Lyme disease with antibiotics and often recover.

Excessive growth of uncertainty bacteria:

As well as other antibiotics, using Cefuroxim acetyl can cause excessive growth of candidiasis. Prolonged use can cause excessive growth of other non -sensitive bacteria (for example, Enterococci and Clostridium difficile), then may need to stop treatment.

Palm colitis has been reported when taking antibiotics, and may occur from mild to life -threatening. Therefore, this diagnosis is needed in patients with diarrhea during or after antibiotics.

Should stop using Cefuroxim acetyl and replace it with another appropriate therapy for treatment, do not use intestinal inhibitors.

affect testing:

Using Cefuroxime Acetil can give a false positive result with the Coombs test. This affects the results of diagonal tests with blood.

Because fake negative results can occur when using Ferricyanide tests, the use of oxidase or hexokinase should be used to determine the plasma/plasma glucose levels in patients using cefuroxim acetyl.

Warning about excipients:

The drug contains lactose ingredients, patients with rare genetic problems such as galactose intolerance, lactase deficiency or glucose-galactose abutment should not use this drug.

The ability to drive and operate machinery

There is no information on the effect of the drug on the ability to drive, operate machinery. However, because the drug can cause dizziness, need to be cautious for drivers, operate machinery.

Pregnancy

There is very little information related to the use of drugs in pregnant women, animal studies show that the drug does not cause harm to the embryo as well as the development of the fetus. Cezirnate 500mg should only be used for pregnant women when the benefits are superior to the risk.

The period of breastfeeding

cefuroxim is excreted in small amounts, can not rule out the risk of diarrhea and fungal infections in the mucosa, so it is possible to stop the drug while breastfeeding due to these adverse effects. Sensitive ability should be considered. CEZIRNATE 500mg should only be used during breastfeeding when there is an assessment of the benefit/risk of a doctor.

Drug interaction

Medications that reduce the acidity of gastric juice can reduce the bioavailability of Cezirnate 500mg Mg compared to bioavailability when hungry and tend to lose the effect of strengthening after meals. Cezirnate 500 mg can affect the intestinal bacteria system, leading to reducing estrogen reception, and reducing the effectiveness of oral contraceptives used in combination.

Cefuroxim is excreted through glomerular and renal filter, not recommended to simultaneously use Cezirnate 500mg with probenicid because it increases the peak concentration, the area under the curve and the disposal time of the drug.

Concentrated use Cezirnate 500mg with oral anticoagulant drugs can increase Inr.

Storage

In a dry place, avoiding light, the temperature does not exceed 30 ° C.

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